Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jessica M. Strasser"'
Autor:
Jayme L. Dahlin, Kathryn M. Nelson, Jessica M. Strasser, Dalia Barsyte-Lovejoy, Magdalena M. Szewczyk, Shawna Organ, Matthew Cuellar, Gurpreet Singh, Jonathan H. Shrimp, Nghi Nguyen, Jordan L. Meier, Cheryl H. Arrowsmith, Peter J. Brown, Jonathan B. Baell, Michael A. Walters
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
A substantial obstacle in basic research is the use of poorly validated tool compounds with purported useful biological functions. Here, the authors systematically profile widely used histone acetyltransferase inhibitors and find that the majority ar
Externí odkaz:
https://doaj.org/article/8ca9ff19d5524b75acdb413bf0ff0f30
Autor:
Gurpreet Singh, Peng Liu, Katherine R. Yao, Jessica M. Strasser, Chris Hlynialuk, Kailee Leinonen-Wright, Peter J. Teravskis, Jessica M. Choquette, Junaid Ikramuddin, Merlin Bresinsky, Kathryn M. Nelson, Dezhi Liao, Karen H. Ashe, Michael A. Walters, Steffen Pockes
Publikováno v:
ACS Chem Neurosci
Synaptic and cognitive deficits mediated by a severe reduction in excitatory neurotransmission caused by a disproportionate accumulation of the neuronal protein tau in dendritic spines is a fundamental mechanism that has been found repeatedly in mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fcc59c4901a1d0ec5e5c27490609ec0
https://doi.org/10.1021/acschemneuro.2c00100
https://doi.org/10.1021/acschemneuro.2c00100
Autor:
Merlin Bresinsky, Jessica M. Strasser, Bernadette Vallaster, Peng Liu, William M. McCue, Jessica Fuller, Alexander Hubmann, Gurpreet Singh, Kathryn M. Nelson, Matthew E. Cuellar, Carrie M. Wilmot, Barry C. Finzel, Karen H. Ashe, Michael A. Walters, Steffen Pockes
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Alzheimer’s disease (AD) was first described by Alois Alzheimer over 100 years ago, but there is still no overarching theory that can explain its cause in detail. There are also no effective therapies to treat either the cause or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d23dbfa9d69eedac74f0ee60beb7c20
https://doi.org/10.1021/acsptsci.1c00251
https://doi.org/10.1021/acsptsci.1c00251
Autor:
Merlin Bresinsky, Jessica M. Strasser, Alexander Hubmann, Bernadette Vallaster, William M. McCue, Jessica Fuller, Gurpreet Singh, Kathryn M. Nelson, Matthew E. Cuellar, Barry C. Finzel, Karen H. Ashe, Michael A. Walters, Steffen Pockes
Publikováno v:
Arch Pharm (Weinheim)
Since the discovery of the caspase-2 (Casp2)-mediated Δtau314 cleavage product and its associated impact on tauopathies such as Alzheimer's disease, the design of selective Casp2 inhibitors has become a focus in medicinal chemistry research. In the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e68b4fd317071c944f65f1b4f880f97e
https://pubmed.ncbi.nlm.nih.gov/35642311
https://pubmed.ncbi.nlm.nih.gov/35642311
Autor:
Ian P. Street, Benjamin Cleary, Jonathan B. Baell, Jessica M. Strasser, Daniel L. Priebbenow, Hendrik Falk, Michael W. Parker, Susan A. Charman, H. Rachel Lagiakos, Brendon J. Monahan, Michael A. Walters, M.C. Chung, S.J. Hermans, Natalie L. Downer, Matthew E. Cuellar, Jayme L. Dahlin, Helene Jousset Sabroux, Tim Thomas, David J. Leaver, Swapna Varghese, Lian Xue, Karen L. White, Yuxin Sun, Prashant Mujumdar, Kasiram Katneni, Silvia Teguh, Anne K. Voss, Julie Sanchez, Kate E. Jarman, David M. Shackleford, Fei Huang, Ramesh Mudududdla, Nghi Nguyen
Publikováno v:
Journal of Medicinal Chemistry. 63:4655-4684
A high-throughput screen designed to discover new inhibitors of histone acetyltransferase KAT6A uncovered CTX-0124143 (1), a unique aryl acylsulfonohydrazide with an IC50 of 1.0 μM. Using this acylsulfonohydrazide as a template, we herein disclose t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eaf3a6eb34ac40b5b8c570155ff2a49
https://doi.org/10.1021/acs.jmedchem.9b02071
https://doi.org/10.1021/acs.jmedchem.9b02071
Autor:
Girdhar Singh Deora, Aaron J. Oakley, Philip G. Board, Yuji Nakano, Jayme L. Dahlin, Padmaja Tummala, Jonathan B. Baell, Jessica M. Strasser, Yiyue Xie, Michael A. Walters, Melissa Rooke, Matthew E. Cuellar, Marco G. Casarotto
Publikováno v:
Journal of Medicinal Chemistry. 63:2894-2914
Glutathione transferase omega-1 (GSTO1-1) is an enzyme whose function supports the activation of interleukin (IL)-1β and IL-18 that are implicated in a variety of inflammatory disease states for which small-molecule inhibitors are sought. The potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d34d91fc9b9fcdcb3312475033c026
https://doi.org/10.1021/acs.jmedchem.9b01391
https://doi.org/10.1021/acs.jmedchem.9b01391
Autor:
Jayme L Dahlin, Rondedrick Sinville, Jonathan Solberg, Hui Zhou, Junhong Han, Subhashree Francis, Jessica M Strasser, Kristen John, Derek J Hook, Michael A Walters, Zhiguo Zhang
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78877 (2013)
The lysine acetyltransferase (KAT) Rtt109 forms a complex with Vps75 and catalyzes the acetylation of histone H3 lysine 56 (H3K56ac) in the Asf1-H3-H4 complex. Rtt109 and H3K56ac are vital for replication-coupled nucleosome assembly and genotoxic res
Externí odkaz:
https://doaj.org/article/23a70466ae2746d7bcc2f8a8d3584186
Autor:
Jessica M. Strasser, Michael A. Walters, Carolyn J. Adamski, Huda Y. Zoghbi, Lisa A. Duvick, Christine Henzler, Nicholas Toker, Jillian Friedrich, Harry T. Orr, Nissa Mollema, Judit M. Pérez Ortiz, Jon E. Hawkinson, Brennon L. O'Callaghan, Sarita Lagalwar
Publikováno v:
Neurobiology of Disease, Vol 116, Iss, Pp 93-105 (2018)
Spinocerebellar ataxia type 1 (SCA1) is a polyglutamine (polyQ) repeat neurodegenerative disease in which a primary site of pathogenesis are cerebellar Purkinje cells. In addition to polyQ expansion of ataxin-1 protein (ATXN1), phosphorylation of ATX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c239893e63322b806cb22edb783e16d
http://www.sciencedirect.com/science/article/pii/S0969996118301402
http://www.sciencedirect.com/science/article/pii/S0969996118301402
Autor:
Youlin Xia, Matthew E. Cuellar, Todd M. Rappe, Jessica M. Strasser, Kathryn M. Nelson, Michael A. Walters, Gianluigi Veglia, Gurpreet Singh, Jayme L. Dahlin
Publikováno v:
Current Protocols in Chemical Biology. 10:91-117
Nonspecific target engagement by test compounds and purported chemical probes is a significant source of assay interference and promiscuous bioactivity in high-throughput screening (HTS) and chemical biology. Most counter-screens for thiol-reactive c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee0e1eb08f474c4c94a2b04ee6b356fb
https://doi.org/10.1002/cpch.35
https://doi.org/10.1002/cpch.35
Autor:
Dalia Barsyte-Lovejoy, Jonathan H. Shrimp, Jonathan B. Baell, Jayme L. Dahlin, Gurpreet Singh, Nghi H. Nguyen, Jessica M. Strasser, Matthew E. Cuellar, Kathryn M. Nelson, Magdalena M. Szewczyk, Jordan L. Meier, Michael A. Walters, Cheryl H. Arrowsmith, Peter Brown, Shawna Organ
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature Communications
Nature Communications
Many compounds with potentially reactive chemical motifs and poor physicochemical properties are published as selective modulators of biomolecules without sufficient validation and then propagated in the scientific literature as useful chemical probe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0de9d782d92b733af7157eaa3d780672
https://doaj.org/article/8ca9ff19d5524b75acdb413bf0ff0f30
https://doaj.org/article/8ca9ff19d5524b75acdb413bf0ff0f30