Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Jessica M. Posada"'
Autor:
Yves Boucher, Ashwin S. Kumar, Jessica M. Posada, Evisa Gjini, Kathleen Pfaff, Mikel Lipschitz, Ana Lako, Dan G. Duda, Scott J. Rodig, F. Stephen Hodi, Rakesh K. Jain
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-6 (2021)
Abstract A single dose of bevacizumab reduced the density of angiopoietin-2-positive vessels while improving the infiltration of CD4+ T and CD8+ T cells, and mature dendritic cells in patients with primary triple-negative breast cancer. Our findings
Externí odkaz:
https://doaj.org/article/2d357221a247457589d886c5e06e1e3d
Autor:
Zohreh Amoozgar, Jonas Kloepper, Jun Ren, Rong En Tay, Samuel W. Kazer, Evgeny Kiner, Shanmugarajan Krishnan, Jessica M. Posada, Mitrajit Ghosh, Emilie Mamessier, Christina Wong, Gino B. Ferraro, Ana Batista, Nancy Wang, Mark Badeaux, Sylvie Roberge, Lei Xu, Peigen Huang, Alex K. Shalek, Dai Fukumura, Hye-Jung Kim, Rakesh K. Jain
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Glioblastomas (GBM) are frequently resistant to immune checkpoint blockade therapy. Here the authors show that treatment with an agonistic anti-GITR antibody converts tumor infiltrating regulatory T cells to effector cells, overcoming resistance to P
Externí odkaz:
https://doaj.org/article/1ab21691b67f4af6a88731fc02b3c2eb
Autor:
Yves Boucher, Jessica M. Posada, Sonu Subudhi, Ashwin S. Kumar, Spencer R. Rosario, Liqun Gu, Heena Kumra, Mari Mino-Kenudson, Nilesh P. Talele, Dan G. Duda, Dai Fukumura, Jennifer Y. Wo, Jeffrey W. Clark, David P. Ryan, Carlos Fernandez-Del Castillo, Theodore S. Hong, Mikael J. Pittet, Rakesh K. Jain
Publikováno v:
Clinical Cancer Research. 29:1605-1619
Purpose: Adding losartan (LOS) to FOLFIRINOX (FFX) chemotherapy followed by chemoradiation (CRT) resulted in 61% R0 surgical resection in our phase II trial in patients with locally advanced pancreatic cancer (LAPC). Here we identify potential mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a172e9457377d283c4f90bae25db37f3
https://doi.org/10.1158/1078-0432.ccr-22-1630
https://doi.org/10.1158/1078-0432.ccr-22-1630
Autor:
Rakesh K. Jain, Mikael J. Pittet, Theodore S. Hong, Carlos Fernandez-Del Castillo, David P. Ryan, Jeffrey W. Clark, Jennifer Y. Wo, Dai Fukumura, Dan G. Duda, Nilesh P. Talele, Mari Mino-Kenudson, Heena Kumra, Liqun Gu, Spencer R. Rosario, Ashwin S. Kumar, Sonu Subudhi, Jessica M. Posada, Yves Boucher
Venn plots and selected GSEA pathways.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32aa766e188dfb7efdbae9354c85712c
https://doi.org/10.1158/1078-0432.22633054.v1
https://doi.org/10.1158/1078-0432.22633054.v1
Autor:
Rakesh K. Jain, Mikael J. Pittet, Theodore S. Hong, Carlos Fernandez-Del Castillo, David P. Ryan, Jeffrey W. Clark, Jennifer Y. Wo, Dai Fukumura, Dan G. Duda, Nilesh P. Talele, Mari Mino-Kenudson, Heena Kumra, Liqun Gu, Spencer R. Rosario, Ashwin S. Kumar, Sonu Subudhi, Jessica M. Posada, Yves Boucher
Longitudinal analysis of circulating biomarkers in the plasma of treated patients.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1f148ae1cbc18e85df3cde2c1dc852
https://doi.org/10.1158/1078-0432.22633018.v1
https://doi.org/10.1158/1078-0432.22633018.v1
Autor:
Rakesh K. Jain, Mikael J. Pittet, Theodore S. Hong, Carlos Fernandez-Del Castillo, David P. Ryan, Jeffrey W. Clark, Jennifer Y. Wo, Dai Fukumura, Dan G. Duda, Nilesh P. Talele, Mari Mino-Kenudson, Heena Kumra, Liqun Gu, Spencer R. Rosario, Ashwin S. Kumar, Sonu Subudhi, Jessica M. Posada, Yves Boucher
Purpose:Adding losartan (LOS) to FOLFIRINOX (FFX) chemotherapy followed by chemoradiation (CRT) resulted in 61% R0 surgical resection in our phase II trial in patients with locally advanced pancreatic cancer (LAPC). Here we identify potential mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13001e66444ae716730ec0d78389351c
https://doi.org/10.1158/1078-0432.c.6533155.v1
https://doi.org/10.1158/1078-0432.c.6533155.v1
Autor:
Pin-Ji Lei, Ethel R. Pereira, Patrik Andersson, Zohreh Amoozgar, Jan Willem Van Wijnbergen, Meghan O’Melia, Hengbo Zhou, Sampurna Chatterjee, William W. Ho, Jessica M. Posada, Ashwin Srinivasan Kumar, Satoru Morita, Charlie Chung, Ilgin Ergin, Dennis Jones, Peigen Huang, Semir Beyaz, Timothy P. Padera
SummaryTumor-draining lymph nodes are critical sites for generating tumor antigen-specific T cells and are associated with durable immune responses. However, lymph nodes are often the first site of metastasis and lymph node metastases portend worse o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e30d68cf9b4795841607f60a9d7fec9
https://doi.org/10.1101/2022.10.30.514441
https://doi.org/10.1101/2022.10.30.514441
Autor:
Scott J. Rodig, Kathleen L. Pfaff, Yves Boucher, Dan G. Duda, Evisa Gjini, Mikel Lipschitz, Rakesh K. Jain, Ana Lako, Ashwin S. Kumar, F. Stephen Hodi, Jessica M. Posada
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-6 (2021)
NPJ Precision Oncology
NPJ Precision Oncology
A single dose of bevacizumab reduced the density of angiopoietin-2-positive vessels while improving the infiltration of CD4+ T and CD8+ T cells, and mature dendritic cells in patients with primary triple-negative breast cancer. Our findings provide a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b45e9b14cc2492ef71c80d2a6b2b0f6
https://doaj.org/article/2d357221a247457589d886c5e06e1e3d
https://doaj.org/article/2d357221a247457589d886c5e06e1e3d
Autor:
Yves Boucher, Jessica M. Posada, Sonu Subudhi, Spencer R. Rosario, Liqun Gu, Ashwin S. Kumar, Heena Kumra, Mari Mino-Kenudson, Nilesh P. Talele, Dan G. Duda, Dai Fukumura, Jennifer Y. Wo, Jeffrey W. Clark, David P. Ryan, Carlos Fernandez-Del Castillo, Theodore S. Hong, Mikael J. Pittet, Rakesh K. Jain
PurposeAdding losartan to FOLFIRINOX (FFX) chemotherapy followed by chemoradiation (CRT) resulted in 61% R0 surgical resection in our phase II trial in patients with locally advanced pancreatic cancer (LAPC). Here we identify potential mechanisms of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab0c2d1d026eca37ea1fa6ba66b90a21
https://doi.org/10.1101/2022.06.09.22275912
https://doi.org/10.1101/2022.06.09.22275912
Autor:
Pin-Ji Lei, Ethel Pereira, Patrik Andersson, Zohreh Amoozgar, Jan Willem Van Wijnbergen, Meghan J. O'Melia, Hengbo Zhou, Sampurna Chatterjee, William Wee Ho, Jessica M. Posada, Ashwin Srinivasan Kumar, Satoru Morita, Charlie Chuang, Ilgin Ergin, Dennis Jones, Peigen Huang, Semir Beyaz, Timothy P. Padera
Publikováno v:
Cancer Research. 83:1298-1298
Tumor-draining lymph nodes are critical sites for generating tumor antigen-specific T cells and are associated with durable immune responses. However, lymph nodes are often the first site of metastasis and lymph node metastases portend worse outcomes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab8b0102b66bf42d0eb741d604739f28
https://doi.org/10.1158/1538-7445.am2023-1298
https://doi.org/10.1158/1538-7445.am2023-1298