Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jessica M. Marbourg"'
Autor:
Randall S. Carpenter, Jessica M. Marbourg, Faith H. Brennan, Katherine A. Mifflin, Jodie C. E. Hall, Roselyn R. Jiang, Xiaokui M. Mo, Malith Karunasiri, Matthew H. Burke, Adrienne M. Dorrance, Phillip G. Popovich
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Spinal cord injury (SCI) often leads to immune dysfunction, but mechanistic insights are still lacking. Here the authors show that SCI alters chemokine signaling and induces long, persisting defects in hematopoietic stem and progenitor cell migration
Externí odkaz:
https://doaj.org/article/0d1de6f876b2431485cb553f43443b20
Autor:
Faith H. Brennan, Phillip G. Popovich, Jessica M. Marbourg, Katherine A. Mifflin, Adrienne M. Dorrance, Xiaokui M. Mo, Randall S. Carpenter, Matthew H. Burke, Roselyn R. Jiang, Jodie C. E. Hall, Malith Karunasiri
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Spinal cord injury (SCI) causes immune dysfunction, increasing the risk of infectious morbidity and mortality. Since bone marrow hematopoiesis is essential for proper immune function, we hypothesize that SCI disrupts bone marrow hematopoiesis. Indeed
Autor:
Lu Xu, Alan D. Flechtner, L. James Lee, Qiwen Shen, Paolo Fadda, Lianbo Yu, Jessica M. Marbourg, Rumana Yasmeen, Phillip G. Popovich, Ouliana Ziouzenkova
Publikováno v:
Translational Research. 192:1-14
Innervation is a fundamental basis for function and survival of tissues. In the peripheral tissues, degenerative diseases create a neurotoxic metabolic milieu that either causes neurodegeneration or fails to sustain regenerative growth and reinnervat
Publikováno v:
Journal of Neurotrauma. 34:1149-1155
People who suffer a traumatic spinal cord injury (SCI) are at increased risk for developing dermatological complications. These conditions increase cost of care, incidence of rehospitalization, and the risk for developing other infections. The conseq
Autor:
Phillip G. Popovich, Devra Huey, Randall S. Carpenter, Kristina A. Kigerl, Jessica M. Marbourg, Stefan Niewiesk, Andrew D. Gaudet
Publikováno v:
Experimental Neurology. 271:432-444
Mouse models have provided key insight into the cellular and molecular control of human immune system function. However, recent data indicate that extrapolating the functional capabilities of the murine immune system into humans can be misleading. Si
Publikováno v:
Journal of Neuroscience. 35:12325-12327
This study investigated the role of the complement activation fragment C5a in secondary pathology following contusive spinal cord injury (SCI). C5ar(−/−) mice, which lack the signaling receptor for C5a, displayed signs of improved locomotor recov