Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jessica M. B. Rees"'
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0222362 (2019)
Methods have been developed for Mendelian randomization that can obtain consistent causal estimates under weaker assumptions than the standard instrumental variable assumptions. The median-based estimator and MR-Egger are examples of such methods. Ho
Externí odkaz:
https://doaj.org/article/2aede4651f9c45eda0384783b8d53634
Autor:
Euan A. Sandilands, Jessica M. B. Rees, Khuram Raja, Neeraj Dhaun, Emma E. Morrison, Kirsty Hickson, Jonathan Wraight, Tanya Gray, Lesley Briody, Sharon Cameron, Adrian P. Thompson, Neil R. Johnston, Neal Uren, Jane Goddard, Andy Treweeke, Gordon Rushworth, David J. Webb, D. Nicholas Bateman, John Norrie, Ian L. Megson, Michael Eddleston
Publikováno v:
Sandilands, E A, Rees, J MB, Raja, K, Dhaun, N, Morrison, E E, Hickson, K, Wraight, J, Gray, T, Briody, L, Cameron, S, Thompson, A P, Johnston, N R, Uren, N, Goddard, J, Treweeke, A, Rushworth, G, Webb, D J, Bateman, N, Norrie, J, Megson, I & Eddleston, M 2022, ' Acetylcysteine has No Mechanistic Effect in Patients at Risk of Contrast-Induced Nephropathy-A Failure of Academic Clinical Science ', Clinical pharmacology and therapeutics . https://doi.org/10.1002/cpt.2541
Contrast-induced nephropathy (CIN) is a major complication of imaging in patients with chronic kidney disease (CKD). The publication of an academic randomized controlled trial (RCT; n = 83) reporting oral (N)-acetylcysteine (NAC) to reduce CIN led to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf68dc214969b61a07ee0f99e8a36c71
https://doi.org/10.1002/cpt.2541
https://doi.org/10.1002/cpt.2541
Autor:
Ole-Jørgen Bekkevold, Stein Hallan, Jie Zheng, George Davey Smith, Solfrid Romundstad, Maiken Elvestad Gabrielsen, Bjørn Olav Åsvold, Ben Michael Brumpton, Humaira Rasheed, Kristian Hveem, Laurent F. Thomas, Jessica M. B. Rees, Tom G. Richardson, Si Fang, Tom R. Gaunt, Eleanor Sanderson, Anne Heidi Skogholt, Cristen J. Willer, Stephen Burgess, Endre Bakken Stovner
Publikováno v:
Rasheed, H, Zheng, J, Rees, J, Sanderson, E, Thomas, L, Richardson, T G, Fang, S, Bekkevold, O-J, Stovner, E B, Gabrielsen, M E, Skogholt, A H, Romundstad, S, Brumpton, B, Hallan, S, Willer, C, Burgess, S, Hveem, K, Davey Smith, G, Gaunt, T R & Asvold, B O 2021, ' The causal effects of serum lipids and apolipoproteins on kidney function : multivariable and bidirectional Mendelian randomization analyses ', International Journal of Epidemiology, vol. 50, no. 5, pp. 1569-1579 . https://doi.org/10.1093/ije/dyab014
International Journal of Epidemiology
International Journal of Epidemiology
Background The causal nature of the observed associations between serum lipids and apolipoproteins and kidney function are unclear. Methods Using two-sample and multivariable Mendelian randomization (MR), we examined the causal effects of serum lipid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55af640fb283255c523044e266fc25a
https://www.repository.cam.ac.uk/handle/1810/317769
https://www.repository.cam.ac.uk/handle/1810/317769
Autor:
Livia A. Carvalho, Amy M. Mason, Verena Zuber, Jessica M. B. Rees, Stephen Burgess, Christopher N. Foley, Gulam Khandaker, Apostolos Gkatzionis, Peter B. Jones
Publikováno v:
Khandaker, G M, Zuber, V, Rees, J M B, Carvalho, L, Mason, A M, Foley, C N, Gkatzionis, A, Jones, P B & Burgess, S 2020, ' Correction : Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort ', Molecular Psychiatry, vol. (2020) 25, pp. 1477-1486 . https://doi.org/10.1038/s41380-020-0857-7
Molecular Psychiatry
Molecular Psychiatry
While comorbidity between coronary heart disease (CHD) and depression is evident, it is unclear whether the two diseases have shared underlying mechanisms. We performed a range of analyses in 367,703 unrelated middle-aged participants of European anc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6969224e5a49e32c7303a0ef8d03ef00
https://hdl.handle.net/1983/12f924e7-acd0-42f7-abbd-d2c97c0c18e3
https://hdl.handle.net/1983/12f924e7-acd0-42f7-abbd-d2c97c0c18e3
Autor:
Stephen Burgess, Peter Broderick, Yann C. Klimentidis, Marion F Walker, Jessica M B Rees, Maria Timofeeva, Xiaomeng Zhang, Harry Campbell, Philip J. Law, Ian Tomlinson, Richard S. Houlston, Evropi Theodoratou, Susan M. Farrington, Xue Li, Malcolm G. Dunlop
Publikováno v:
British Journal of Cancer
Zhang, X, Theodoratou, E, Li, X, Farrington, S M, Law, P J, Broderick, P, Walker, M, Klimentidis, Y C, Rees, J M B, Houlston, R S, Tomlinson, I P M, Burgess, S, Campbell, H, Dunlop, M G & Timofeeva, M 2021, ' Genetically predicted physical activity levels are associated with lower colorectal cancer risk : a Mendelian randomisation study ', British Journal of Cancer, vol. 124, no. 7, pp. 1330-1338 . https://doi.org/10.1038/s41416-020-01236-2
Zhang, X, Theodoratou, E, Li, X, Farrington, S M, Law, P J, Broderick, P, Walker, M, Kimentidis, Y C, Rees, J, Houlston, R S, Tomlinson, I P M, Burgess, S, Campbell, H, Dunlop, M G & Timofeeva, M 2021, ' Genetically-predicted physical activity levels are associated with lower colorectal cancer risk: a Mendelian Randomization Study ', British Journal of Cancer . https://doi.org/10.1038/s41416-020-01236-2
Zhang, X, Theodoratou, E, Li, X, Farrington, S M, Law, P J, Broderick, P, Walker, M, Klimentidis, Y C, Rees, J M B, Houlston, R S, Tomlinson, I P M, Burgess, S, Campbell, H, Dunlop, M G & Timofeeva, M 2021, ' Genetically predicted physical activity levels are associated with lower colorectal cancer risk : a Mendelian randomisation study ', British Journal of Cancer, vol. 124, no. 7, pp. 1330-1338 . https://doi.org/10.1038/s41416-020-01236-2
Zhang, X, Theodoratou, E, Li, X, Farrington, S M, Law, P J, Broderick, P, Walker, M, Kimentidis, Y C, Rees, J, Houlston, R S, Tomlinson, I P M, Burgess, S, Campbell, H, Dunlop, M G & Timofeeva, M 2021, ' Genetically-predicted physical activity levels are associated with lower colorectal cancer risk: a Mendelian Randomization Study ', British Journal of Cancer . https://doi.org/10.1038/s41416-020-01236-2
Funder: The Darwin Trust of Edinburgh
Funder: National Institute of Health [grant number R01 HL136528]
BACKGROUND: We conducted a Mendelian randomisation (MR) study to investigate whether physical activity (PA) causes a reduction of colorec
Funder: National Institute of Health [grant number R01 HL136528]
BACKGROUND: We conducted a Mendelian randomisation (MR) study to investigate whether physical activity (PA) causes a reduction of colorec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::168988f02fd779fe4ebdaf1dadefed59
https://pubmed.ncbi.nlm.nih.gov/33510439
https://pubmed.ncbi.nlm.nih.gov/33510439
Publikováno v:
European Heart Journal
Aims The causal role of adiposity for several cardiovascular diseases (CVDs) is unclear. Our primary aim was to apply the Mendelian randomization design to investigate the associations of body mass index (BMI) with 13 CVDs and arterial hypertension.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f8dac397f511a478193141a190a7086
https://www.repository.cam.ac.uk/handle/1810/293124
https://www.repository.cam.ac.uk/handle/1810/293124
Autor:
Jessica M. B. Rees, Gabriele Morani, Emanuele Di Angelantonio, Apostolos Gkatzionis, Adam S. Butterworth, Verena Zuber, Sara Lindström, Steven Bell, Dipender Gill, Paul Carter, Amy M. Mason, Christopher N. Foley, Elias Allara, James E. Peters, Stephen Burgess
Publikováno v:
Allara, E, Morani, G, Carter, P, Gkatzionis, A, Zuber, V, Foley, C N, Rees, J M, Mason, A M, Bell, S, Gill, D, Lindstroem, S, Butterworth, A S, Di Angelantonio, E, Peters, J & Burgess, S 2019, ' Genetic Determinants of Lipids and Cardiovascular Disease Outcomes : A Wide-angled Mendelian Randomization Investigation ', Circulation: Genomic and Precision Medicine . https://doi.org/10.1161/CIRCGEN.119.002711
Background: Evidence from randomized trials has shown that therapies that lower LDL (low-density lipoprotein)-cholesterol and triglycerides reduce coronary artery disease (CAD) risk. However, there is still uncertainty about their effects on other ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c241af1676bfe431939caf4286d24f9
http://hdl.handle.net/10044/1/75158
http://hdl.handle.net/10044/1/75158
Autor:
Marion Walker, Malcolm G. Dunlop, Maria Timofeeva, Xiaomeng Zhang, Richard S. Houlston, Harry Campbell, Ian Tomlinson, Evropi Theodoratou, Xue Li, Susan M. Farrington, Jessica M B Rees, Philip J. Law, Peter Broderick
BackgroundEvidence from observational studies suggests a protective role for physical activity (PA) against colorectal cancer (CRC) risk. However, it has yet to be established a causal relationship. We conducted a two-sample Mendelian randomisation (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9abf529a927808ea42c40557226fb589
Publikováno v:
Rees, J M B, Wood, A M, Dudbridge, F & Burgess, S 2019, ' Robust methods in Mendelian randomization via penalization of heterogeneous causal estimates ', PLoS ONE, vol. 14, no. 9, pp. e0222362 . https://doi.org/10.1371/journal.pone.0222362
PLoS ONE, Vol 14, Iss 9, p e0222362 (2019)
PLoS ONE
PLoS ONE, Vol 14, Iss 9, p e0222362 (2019)
PLoS ONE
Methods have been developed for Mendelian randomization that can obtain consistent causal estimates under weaker assumptions than the standard instrumental variable assumptions. The median-based estimator and MR-Egger are examples of such methods. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8092e65410c210360c2601eedc36ec
https://hdl.handle.net/20.500.11820/9bf9bd16-3a18-48fb-816b-dee2263149c1
https://hdl.handle.net/20.500.11820/9bf9bd16-3a18-48fb-816b-dee2263149c1
Publikováno v:
Rees, J, Foley, C & Burgess, S 2019, ' Factorial Mendelian randomization: using genetic variants to assess interactions ', International Journal of Epidemiology . https://doi.org/10.1093/ije/dyz161
International Journal of Epidemiology
International Journal of Epidemiology
BackgroundFactorial Mendelian randomization is the use of genetic variants to answer questions about interactions. Although the approach has been used in applied investigations, little methodological advice is available on how to design or perform a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64d55a0c7ac1eb7cb788d11565e3fbbe