Výsledky vyhledávání - "Jessica M Y, Ng"

Data from Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma

Autor: Zeng-Jie Yang, Tom Curran, Igor Astsaturov, Andrew J. Andrews, Jessica M. Y. Ng, Brian L. Egleston, Fang Du, Yin-Ming Kuo, Suraj Peri, Li Zhang, Renata E. Gordon

Purpose: The role of cholesterol biosynthesis in hedgehog pathway activity and progression of hedgehog pathway medulloblastoma (Hh-MB) were examined in vivo. Statins, commonly used cholesterol-lowering agents, were utilized to validate cholesterol bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3513d9e8b83b0eb328509b73012fa153
https://doi.org/10.1158/1078-0432.c.6524853.v1

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Statins repress hedgehog signaling in medulloblastoma with no bone toxicities

Autor: Qianhai, Fan, Tingting, Gong, Chaonan, Zheng, Jessica M Y, Ng, Jianquan, Chen, Cynthia, Myers, Harvey, Hensley, Tom, Curran, Zeng-Jie, Yang

Publikováno v: Oncogene. 40(12)

The Hedgehog (Hh) pathway plays an indispensable role in bone development and genetic activation of the pathway results in medulloblastoma (MB), the most common malignant brain tumor in children. Inhibitors of Hh pathway (such as vismodegib and soned

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f1c8946f5f6d91da86a350582c5b9f25
https://pubmed.ncbi.nlm.nih.gov/33649536

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Akademický článek

Dynamic interaction of TTDA with TFIIH is stabilized by nucleotide excision repair in living cells.

Autor: Giuseppina Giglia-Mari, Catherine Miquel, Arjan F Theil, Pierre-Olivier Mari, Deborah Hoogstraten, Jessica M Y Ng, Christoffel Dinant, Jan H J Hoeijmakers, Wim Vermeulen

Publikováno v: PLoS Biology, Vol 4, Iss 6, p e156 (2006)

Transcription/repair factor IIH (TFIIH) is essential for RNA polymerase II transcription and nucleotide excision repair (NER). This multi-subunit complex consists of ten polypeptides, including the recently identified small 8-kDa trichothiodystrophy

Externí odkaz: https://doaj.org/article/9b5cec00a6f2471d8895e60b61883ddf

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Relative levels of the two mammalian Rad23 homologs determine composition and stability of the xeroderma pigmentosum group C protein complex

Autor: Jessica M. Y. Ng, Wim Vermeulen, Yuki Okuda, Fumio Hanaoka, Toshio Mori, Jan H.J. Hoeijmakers, Gijsbertus T. J. van der Horst, Ryotaro Nishi, Kaoru Sugasawa

Publikováno v: DNA Repair, 3, 1285-1295. Elsevier

Mammalian cells express two Rad23 homologs, HR23A and HR23B, which have been implicated in regulation of proteolysis via the ubiquitin/proteasome pathway. Recently, the proteins have been shown to stabilize xeroderma pigmentosum group C (XPC) protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::404e36fe8eb5f1e4cbee69624e00a6dd
https://doi.org/10.1016/j.dnarep.2004.06.010

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Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways

Autor: Shiunichi Takeda, Yukiko M. Yamashita, Trevor C. McMorris, Jan H.J. Hoeijmakers, Anja Raams, Jessica M. Y. Ng, Nicolaas G. J. Jaspers, Michael J. Kelner

Publikováno v: DNA Repair. 1:1027-1038

Illudin S is a natural sesquiterpene drug with strong anti-tumour activity. Inside cells, unstable active metabolites of illudin cause the formation of as yet poorly characterised DNA lesions. In order to identify factors involved in their repair, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad47e8ca2dea00ca860111b7fff195ff
https://doi.org/10.1016/s1568-7864(02)00166-0

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Developmental Defects and Male Sterility in Mice Lacking the Ubiquitin-Like DNA Repair Gene mHR23B

Autor: Gijsbertus T. J. van der Horst, Fumio Hanaoka, Kaoru Sugasawa, Jessica M. Y. Ng, Rudolph B. Beems, Harry Vrieling, M. P. Ooms, J. T. M. Vreeburg, Theo G M F Gorgels, J. Anton Grootegoed, Jan H.J. Hoeijmakers, Pim Visser

Publikováno v: Molecular and Cellular Biology, 22(4), 1233-1245. American Society for Microbiology

mHR23B encodes one of the two mammalian homologs of Saccharomyces cerevisiae RAD23, a ubiquitin-like fusion protein involved in nucleotide excision repair (NER). Part of mHR23B is complexed with the XPC protein, and this heterodimer functions as the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80be653a7092cea63880e80394b04da8
https://doi.org/10.1128/mcb.22.4.1233-1245.2002

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Two Human Homologs of Rad23 Are Functionally Interchangeable in Complex Formation and Stimulation of XPC Repair Activity

Autor: T. Maekawa, A. Aboussekhra, Richard D. Wood, Kaoru Sugasawa, Chikahide Masutani, André P. M. Eker, Fumio Hanaoka, Cécile E. Visser, Jessica M. Y. Ng, A. Uchida, J.H.J. Hoeijmakers, Suzanne Rademakers, Dirk Bootsma, P.J. van der Spek

Publikováno v: Scopus-Elsevier

XPC-hHR23B protein complex is specifically involved in nucleotide excision repair (NER) of DNA lesions on transcriptionally inactive sequences as well as the nontranscribed strand of active genes. Here we demonstrate that not only highly purified rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c651a805b57b42a093445b5edefeabe7
https://doi.org/10.1128/mcb.17.12.6924

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A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein

Autor: Jessica M. Y. Ng, Jan H.J. Hoeijmakers, Steven Bergink, Gijsbertus T. J. van der Horst, Kaoru Sugasawa, Wim Vermeulen, Harry Vrieling

Publikováno v: Genesdevelopment. 17(13)

Primary DNA damage sensing in mammalian global genome nucleotide excision repair (GG-NER) is performed by the xeroderma pigmentosum group C (XPC)/HR23B protein complex. HR23B and HR23A are human homologs of the yeast ubiquitin-domain repair factor RA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d1ea0fe5a71e0c22ee9e797df233731
https://pubmed.ncbi.nlm.nih.gov/12815074

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