Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jessica M, Thanos"'
Autor:
Francesca Rapino, Ted Natoli, Francesco Limone, Erin O’Connor, Jack Blank, Matthew Tegtmeyer, William Chen, Erika Norabuena, Juhi Narula, Dane Hazelbaker, Gabriella Angelini, Lindy Barrett, Alison O’Neil, Ursula K. Beattie, Jessica M. Thanos, Heather de Rivera, Steven D. Sheridan, Roy H. Perlis, Steven A. McCarroll, Beth Stevens, Aravind Subramanian, Ralda Nehme, Lee L. Rubin
Publikováno v:
Stem Cell Reports, Vol 18, Iss 1, Pp 237-253 (2023)
Summary: In the brain, the complement system plays a crucial role in the immune response and in synaptic elimination during normal development and disease. Here, we sought to identify pathways that modulate the production of complement component 4 (C
Externí odkaz:
https://doaj.org/article/660be2f0da164413bfeab8d8ecac144d
Autor:
Steven D. Sheridan, Jessica M. Thanos, Rose M. De Guzman, Liam T. McCrea, Joy E. Horng, Ting Fu, Carl M. Sellgren, Roy H. Perlis, Andrea G. Edlow
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Microglia, the resident brain immune cells, play a critical role in normal brain development, and are impacted by the intrauterine environment, including maternal immune activation and inflammatory exposures. The COVID-19 pandemic presents a
Externí odkaz:
https://doaj.org/article/1200a4df08474dbdab686afff0fab8e8
Autor:
Ariel Feiglin, Jennifer P. Wang, Thomas O Dial, Steven D. Sheridan, Smita Jagtap, Jeffrey Chen, Ting Fu, Jasmin Lalonde, Roy H. Perlis, Jeannie T. Lee, Isaac S. Kohane, Jessica M. Thanos
Publikováno v:
Human Molecular Genetics. 28:3625-3636
The X-linked neurodevelopmental diseases CDKL5 deficiency disorder (CDD) and Rett syndrome (RTT) are associated with intellectual disability, infantile spasms and seizures. Although mitochondrial dysfunction has been suggested in RTT, less is underst
Autor:
Jessica M. Thanos, Jessica Gracias, Carl M. Sellgren, Roy H. Perlis, Ajamete Kaykas, Rakesh Karmacharya, Kathleen A. Worringer, Paul B. Whittredge, Carleton Goold, Steven D. Sheridan, Jonathan D. Biag, Hannah E. Brown, Bradley Watmuff, Ting Fu, Jennifer P. Wang
Publikováno v:
Nature Neuroscience. 22:374-385
Synapse density is reduced in postmortem cortical tissue from schizophrenia patients, which is suggestive of increased synapse elimination. Using a reprogrammed in vitro model of microglia-mediated synapse engulfment, we demonstrate increased synapse
Autor:
Carl M. Sellgren, Joy E. Horng, Andrea G. Edlow, Steven D. Sheridan, Liam T. McCrea, Roy H. Perlis, Rose M. De Guzman, Ting Fu, Jessica M. Thanos
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Microglia, the resident brain immune cells, play a critical role in normal brain development, and are impacted by the intrauterine environment, including maternal immune activation and inflammatory exposures. The COVID-19 pandemic presents a potentia
Autor:
Alex Powers, Francis J. Malarkey, Emalee Peterson, Joshua P. Head, Melanie P. Leussis, Nathan J. McGovern, Anna Drake, Jessica M. Thanos
Publikováno v:
Pharmacology, biochemistry, and behavior. 211
Evidence demonstrates that psychiatric disorders during pregnancy are detrimental to the offspring. Many disorders are treated with SSRIs and increasing numbers of pregnant women now receive these drugs during gestation. The long-term neurobehavioral
Autor:
Roy H. Perlis, Andrea G. Edlow, Joy E. Horng, Rose M. De Guzman, Jessica M. Thanos, Ting Fu, Steven D. Sheridan, Carl M. Sellgren, Liam T. McCrea
Publikováno v:
Translational Psychiatry
bioRxiv
bioRxiv
Microglia, the resident brain immune cells, play a critical role in normal brain development, and are impacted by the intrauterine environment, including maternal immune activation and inflammatory exposures. The COVID-19 pandemic presents a potentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5072abe36fdb40f7757938d14986eadd
https://doi.org/10.1101/2020.10.07.329748
https://doi.org/10.1101/2020.10.07.329748
Autor:
Hannah E. Brown, Tian-Ming Fu, Steven D. Sheridan, Junning Wang, Bradley Watmuff, Carl M. Sellgren, Carleton Goold, Jessica M. Thanos, Jessica Gracias, Rakesh Karmacharya, Roy H. Perlis
Schizophrenia patients display decreased synaptic density in postmortem studies, suggesting aberrant microglial synapse elimination during neurodevelopment. Here, we use cellular reprogramming to create patient-specific in vitro models of microglia-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e92077564e0e6076f926b906d336b879