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of 4
pro vyhledávání: '"Jessica Lagerwall"'
Autor:
Larissa Traxler, Jessica Lagerwall, Sophie Eichhorner, Davide Stefanoni, Angelo D'Alessandro, Jerome Mertens
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 8 (2021)
An uninterrupted energy supply is critical for the optimal functioning of all our organs, and in this regard the human brain is particularly energy dependent. The study of energy metabolic pathways is a major focus within neuroscience research, which
Externí odkaz:
https://doaj.org/article/36167fda9b67405caaff154a65d8e67e
Autor:
Karolina Pircs, Janelle Drouin-Ouellet, Vivien Horváth, Jeovanis Gil, Melinda Rezeli, Raquel Garza, Daniela A Grassi, Yogita Sharma, Isabelle St-Amour, Kate Harris, Marie E Jönsson, Pia A Johansson, Romina Vuono, Shaline V Fazal, Thomas Stoker, Bob A Hersbach, Kritika Sharma, Jessica Lagerwall, Stina Lagerström, Petter Storm, Sébastien S Hébert, György Marko-Varga, Malin Parmar, Roger A Barker, Johan Jakobsson
Huntington's disease is a neurodegenerative disorder caused by CAG expansions in the huntingtin (HTT) gene. Modelling Huntington's disease is challenging, as rodent and cellular models poorly recapitulate the disease as seen in ageing humans. To addr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667921ae8a7da270bf48986c499fbc03
https://www.repository.cam.ac.uk/handle/1810/332257
https://www.repository.cam.ac.uk/handle/1810/332257
Autor:
Jessica Lagerwall, Sophie Eichhorner, Larissa Traxler, Jerome Mertens, Davide Stefanoni, Angelo D'Alessandro
Publikováno v:
Disease Models & Mechanisms
article-version (VoR) Version of Record
Disease Models & Mechanisms, Vol 14, Iss 8 (2021)
article-version (VoR) Version of Record
Disease Models & Mechanisms, Vol 14, Iss 8 (2021)
An uninterrupted energy supply is critical for the optimal functioning of all our organs, and in this regard the human brain is particularly energy dependent. The study of energy metabolic pathways is a major focus within neuroscience research, which
Autor:
Larissa Traxler, Joseph R. Herdy, Davide Stefanoni, Sophie Eichhorner, Silvia Pelucchi, Attila Szücs, Alice Santagostino, Yongsung Kim, Ravi K. Agarwal, Johannes C.M. Schlachetzki, Christopher K. Glass, Jessica Lagerwall, Douglas Galasko, Fred H. Gage, Angelo D’Alessandro, Jerome Mertens
Publikováno v:
Cell Metabolism
The drivers of sporadic Alzheimer's disease (AD) remain incompletely understood. Utilizing directly converted induced neurons (iNs) from AD-patient-derived fibroblasts, we identified a metabolic switch to aerobic glycolysis in AD iNs. Pathological is