Mechanosensitive calcium flashes promote sustained RhoA activation during tight junction remodeling

Autor: Saranyaraajan Varadarajan, Shahana A. Chumki, Rachel E. Stephenson, Eileen R. Misterovich, Jessica L. Wu, Claire E. Dudley, Ivan S. Erofeev, Andrew B. Goryachev, Ann L. Miller

Publikováno v: Varadarajan, S, Chumki, S A, Stephenson, R, Misterovich, E R, Wu, J L, Dudley, C E, Erofeev, I, Goryachev, A B & Miller, A L 2022, ' Mechanosensitive calcium flashes promote sustained RhoA activation during tight junction remodeling ', Journal of Cell Biology, vol. 221, no. 4, e202105107 . https://doi.org/10.1083/jcb.202105107

Epithelial cell–cell junctions remodel in response to mechanical stimuli to maintain barrier function. Previously, we found that local leaks in tight junctions (TJs) are rapidly repaired by local, transient RhoA activation, termed “Rho flares,”

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12556182c9f4c6881bc3a7d7a2e041e5
https://doi.org/10.1083/jcb.202105107