Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jessica L. Woolnough"'
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157276 (2016)
It has become increasingly clear that proper cellular control of pluripotency and differentiation is related to the regulation of rRNA synthesis. To further our understanding of the role that the regulation of rRNA synthesis has in pluripotency we mo
Externí odkaz:
https://doaj.org/article/74af4af28dc9419d857a275fd68272e3
Autor:
Heather A. Wallace, Youngsook L. Jung, Peter J. Park, Jessica L. Woolnough, Kyle A. McElroy, Barry M. Zee, Hyuckjoon Kang, Mitzi I. Kuroda
Publikováno v:
Genes & Development. 31:1988-2002
Regulatory decisions in Drosophila require Polycomb group (PcG) proteins to maintain the silent state and Trithorax group (TrxG) proteins to oppose silencing. Since PcG and TrxG are ubiquitous and lack apparent sequence specificity, a long-standing m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d39b07ae03d933113371d50617fd2be0
https://doi.org/10.1101/gad.305987.117
https://doi.org/10.1101/gad.305987.117
Autor:
Jessica L. Woolnough, Keith E. Giles, Gary Felsenfeld, Blake L. Atwood, Gaelle M. Lefevre, Mariana Saint Just Ribeiro
Publikováno v:
Journal of Biological Chemistry. 291:17919-17928
The primary role of the RNAi machinery is to promote mRNA degradation within the cytoplasm in a microRNA-dependent manner. However, both Dicer and the Argonaute protein family have expanded roles in gene regulation within the nucleus. To further our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::528a6f4cb76fb5d9ace4b6e6081aa5f3
https://doi.org/10.1074/jbc.m116.725051
https://doi.org/10.1074/jbc.m116.725051
The human genome consists of 625 tDNA copies that encode 51 distinct isoacceptor families. Recent studies demonstrated that changes in chromatin structure during cellular differentiation can alter the expression of these tDNA. However, the mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe8d40b4426c85607e851455fd3818a
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 6, p e0157276 (2016)
PLoS ONE, Vol 11, Iss 6, p e0157276 (2016)
It has become increasingly clear that proper cellular control of pluripotency and differentiation is related to the regulation of rRNA synthesis. To further our understanding of the role that the regulation of rRNA synthesis has in pluripotency we mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b408dafc345a72f18439bbc1849955
https://pubmed.ncbi.nlm.nih.gov/27299313
https://pubmed.ncbi.nlm.nih.gov/27299313
To further our understanding of the RNAi machinery within the human nucleus, we analyzed the chromatin and RNA binding of Argonaute 2 (AGO2) within human cancer cell lines. Our data indicated that AGO2 binds directly to nascent tRNA and 5S rRNA, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db5a498e3cdc89be0e77f14e0b2ade3
https://europepmc.org/articles/PMC4456445/
https://europepmc.org/articles/PMC4456445/
Recent advances in genome sequencing have led to many surprising discoveries in both humans and many model systems. One of the most important such discoveries has been that the majority of the genome is transcribed. The function of this large transcr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c8a7fa0c3cf5a73332ecad681e1690b
https://doi.org/10.1016/b978-0-12-799958-6.00006-8
https://doi.org/10.1016/b978-0-12-799958-6.00006-8
Autor:
Jessica L. Woolnough, Qiang Wu, Wei Yang, Qian Dai, Amanda Jones, Keith E. Giles, Hengbin Wang, Yun-Hwa Lee, Dewang Zhou, Tim M. Townes
Publikováno v:
Nature communications
Polycomb Repressive Complex 1 and histone H2A ubiquitination (ubH2A) contribute to embryonic stem cell (ESC) pluripotency by repressing lineage-specific gene expression. However, whether active deubiquitination co-regulates ubH2A levels in ESCs and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b698f9d6d2a4efdf72a6e4af959aff3
https://doi.org/10.1038/ncomms4818
https://doi.org/10.1038/ncomms4818