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pro vyhledávání: '"Jessica L. Preston"'
Autor:
Jessica L. Preston, Nicholas Stiffler
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-10 (2020)
Abstract Background The loss of a single copy of adenomatous polyposis coli (Apc) in leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1)-expressing colonic progenitor cells induces rapid growth of adenomas in mice with high penetrance and
Externí odkaz:
https://doaj.org/article/5ebc59493b8240848143f23b6788b1d4
Publikováno v:
PeerJ, Vol 3, p e1527 (2015)
Here we present a genome-wide method for de novo identification of enhancer regions. This approach enables massively parallel empirical investigation of DNA sequences that mediate transcriptional activation and provides a platform for discovery of re
Externí odkaz:
https://doaj.org/article/29af53d8ac044a02a2f3e74ee2f2fb0e
Autor:
Jessica L. Preston, Nicholas Stiffler
Publikováno v:
BMC Cancer
BMC Cancer, Vol 20, Iss 1, Pp 1-10 (2020)
BMC Cancer, Vol 20, Iss 1, Pp 1-10 (2020)
Background The loss of a single copy of adenomatous polyposis coli (Apc) in leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1)-expressing colonic progenitor cells induces rapid growth of adenomas in mice with high penetrance and multiplic
Autor:
Jessica L. Preston
Murine colonic adenomas induced by the loss of a single copy of the tumor suppressor gene Apc in Lrig1+/- expressing progenitor cells grow rapidly, with high penetrance and tumor multiplicity. This study investigates the prevalence of intertumoral ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::445a30e9898894b459859c41fd8c2247
A critical requirement for a systems-level understanding of complex biological processes such as aging is the ability to directly characterize interactions between cells and tissues within a multicellular organism.C. elegansnematodes harboring mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679e8fb00724541f0900e34b62934b49
Autor:
Eric A. Johnson, Ariel Royall, Patrick C. Phillips, Kristin L. Sikkink, Melissa A Randel, Jessica L. Preston
Publikováno v:
BMC Genomics
Background Polymorphic loci exist throughout the genomes of a population and provide the raw genetic material needed for a species to adapt to changes in the environment. The minor allele frequencies of rare Single Nucleotide Polymorphisms (SNPs) wit
Publikováno v:
PeerJ, Vol 3, p e1527 (2015)
PeerJ
PeerJ
Here we present a genome-wide method forde novoidentification of enhancer regions. This approach enables massively parallel empirical investigation of DNA sequences that mediate transcriptional activation and provides a platform for discovery of regu
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 4, p e18561 (2011)
PLoS ONE, Vol 6, Iss 4, p e18561 (2011)
Despite the power of massively parallel sequencing platforms, a drawback is the short length of the sequence reads produced. We demonstrate that short reads can be locally assembled into longer contigs using paired-end sequencing of restriction-site