Výsledky vyhledávání - "Jessica L. O'Rear"

Defects in the N-Linked Oligosaccharide Biosynthetic Pathway in a Trypanosoma brucei Glycosylation Mutant

Autor: Jessica L. O'Rear, Sharon S. Krag, George J. Quellhorst, Paul T. Englund, Soo Hee Lee, Alvaro Acosta-Serrano, Kuo-Yuan Hwa

Publikováno v: Eukaryotic Cell. 3:255-263

Concanavalin A (ConA) kills the procyclic (insect) form of Trypanosoma brucei by binding to its major surface glycoprotein, procyclin. We previously isolated a mutant cell line, ConA 1-1, that is less agglutinated and more resistant to ConA killing t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::190524d68bf915bb5bcd33adfe0d8a3d
https://doi.org/10.1128/ec.3.2.255-263.2004

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Comparison of the hammerhead cleavage reactions stimulated by monovalent and divalent cations

Autor: Andrew L. Feig, Daniel Herschlag, Olke C. Uhlenbeck, Jessica L. O'rear, Leonid Beigelman, Shenglong Wang

Publikováno v: RNA. 7:537-545

Although the hammerhead reaction proceeds most efficiently in divalent cations, cleavage in 4 M LiCl is only approximately 10-fold slower than under standard conditions of 10 mM MgCl2 (Murray et al., Chem Biol, 1998, 5:587-595; Curtis & Bartel, RNA,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9885a6d5728c7a944a514ba733aecf48
https://doi.org/10.1017/s1355838201002461

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Chinese hamster ovary cells with reduced hexokinase activity maintain normal GDP-mannose levels

Autor: Jessica L. O'Rear, Jane R. Scocca, Adina Kaiden, Brian K. Walker, Sharon S. Krag

Publikováno v: Journal of Cellular Biochemistry. 72:56-66

Parental Chinese hamster ovary (CHO) cells were mutagenized and subjected first to a mannose suicide selection technique and second to a screen of individual colonies grown on polyester discs for reduced mannose incorporation into protein. The incorp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9cde10fef88b5eb4170b63aed076fbb
https://doi.org/10.1002/(sici)1097-4644(19990101)72:1<56::aid-jcb7>3.0.co

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Interaction of Oligodeoxyribonucleotides Through Formation of Chimeric Duplex/Triplex Complexes

Autor: David M. Noll, Cynthia D. Cushman, Paul S. Miller, Jessica L. O'Rear

Publikováno v: Nucleosides and Nucleotides. 13:997-1005

An intramolecular duplex/triplex chimera is formed between d-CTTCCT-(T)4-TCCTTCAGCACA and target d-GTT TGTGCTGAAGGA CACAC. The high Tm and hypochromicity of the triplex part of the chimera may be due to additional interactions outside the underlined

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75ad8f13d09e55cc5774b11b37a519b2
https://doi.org/10.1080/15257779408011872

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Nonglucosylated oligosaccharides are transferred to protein in MI8-5 Chinese hamster ovary cells

Autor: René Cacan, Jessica L. O'Rear, André Verbert, George J. Quellhorst, Sharon S. Krag

Publikováno v: Glycobiology. 9(1)

A CHO mutant MI8-5 was found to synthesize Man9-GlcNAc2-P-P-dolichol rather than Glc3Man9GlcNAc2-P-P-dolichol as the oligosaccharide-lipid intermediate in N-glycosylation of proteins. MI8-5 cells were incubated with labeled mevalonate, and the prenol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d84ee4f188fb4b3259cc87eaa7710c
https://pubmed.ncbi.nlm.nih.gov/9884408

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