Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Jessica L. Davis"'
Autor:
Kenneth R. Gundle, Karthik Rajasekaran, Jeffrey Houlton, Gary B. Deutsch, Thomas J. Ow, Robert G. Maki, John Pang, Cherie-Ann O. Nathan, Daniel Clayburgh, Jason G. Newman, Elyse Brinkmann, Michael J. Wagner, Seth M. Pollack, Matthew J. Thompson, Ryan J. Li, Vikas Mehta, Bradley A. Schiff, Barry I. Wenig, Paul L. Swiecicki, Alice L. Tang, Jessica L. Davis, Annemieke van Zante, Jessica A. Bertout, Wendy Jenkins, Atticus Turner, Marc Grenley, Connor Burns, Jason P. Frazier, Angela Merrell, Kimberly H. W. Sottero, Jonathan M. J. Derry, Kate C. Gillespie, Bre Mills, Richard A. Klinghoffer
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: Drug development is systemically inefficient. Research and development costs for novel therapeutics average hundreds of millions to billions of dollars, with the overall likelihood of approval estimated to be as low as 6.7% for oncology
Externí odkaz:
https://doaj.org/article/df356ddd88154387999a5c867f337370
Publikováno v:
Diagnostic Pathology, Vol 18, Iss 1, Pp 1-9 (2023)
Abstract Neuroblastoma is rare in the adult population, especially in thoracic or mediastinal locations, with only 25 previously reported cases. We report an additional example of primary thymic neuroblastoma in a previously asymptomatic 71-year-old
Externí odkaz:
https://doaj.org/article/e48d61f3b7464166b86c1e64caf9235a
Autor:
Niall J. Treacy, Shane Clerkin, Jessica L. Davis, Ciarán Kennedy, Aline F. Miller, Alberto Saiani, Jacek K. Wychowaniec, Dermot F. Brougham, John Crean
Publikováno v:
Bioactive Materials, Vol 21, Iss , Pp 142-156 (2023)
Human induced pluripotent stem cell (hiPSC)-derived kidney organoids have prospective applications ranging from basic disease modelling to personalised medicine. However, there remains a necessity to refine the biophysical and biochemical parameters
Externí odkaz:
https://doaj.org/article/e2d13a4d716e47b4b691e887cb4c6098
Autor:
Jessica L. Davis, Ciaran Kennedy, Shane Clerkin, Niall J. Treacy, Thomas Dodd, Catherine Moss, Alison Murphy, Derek P. Brazil, Gerard Cagney, Dermot F. Brougham, Rabi Murad, Darren Finlay, Kristiina Vuori, John Crean
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-16 (2022)
Multimodal single-cell analysis on iPSC-derived kidney organoids shows that inhibiting EZH2 attenuates TGFβ1-induced fibrotic gene expression and changes in chromatin accessibility, highlighting a potential therapeutic strategy for renal fibrosis.
Externí odkaz:
https://doaj.org/article/7c0970e160e847bc9ea14f1bd75e80a3
Publikováno v:
Human Pathology Reports, Vol 31, Iss , Pp 300689- (2023)
The most common etiologies for chest masses in children include neurogenic tumors, germ cell tumors, leukemia/lymphoma and cysts [1]. Hypercalcemia of malignancy can complicate the clinical course, but is rare in children and most likely to occur in
Externí odkaz:
https://doaj.org/article/b47f94021db34c9b87afa7bb05d9e4ff
Publikováno v:
Frontiers in Communication, Vol 8 (2023)
IntroductionFrom the high-stakes operating room of a Seattle hospital, to the shattered remains of a planet in a galaxy far, far away, Hollywood is often critiqued for its representations of scientific knowledge, methods, and/or technology. Existing
Externí odkaz:
https://doaj.org/article/1a190ec363b94316af79a78e4e7e8687
Autor:
Sudeep Banerjee, Christopher L. Corless, Markku M. Miettinen, Sangkyu Noh, Rowan Ustoy, Jessica L. Davis, Chih-Min Tang, Mayra Yebra, Adam M. Burgoyne, Jason K. Sicklick
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-8 (2019)
Abstract Background Plexiform fibromyxoma (PF) is a rare gastric tumor often confused with gastrointestinal stromal tumor. These so-called “benign” tumors often present with upper GI bleeding and gastric outlet obstruction. It was recently demons
Externí odkaz:
https://doaj.org/article/b7f0ca957c014a85ad57834e27cb486b
Publikováno v:
Human Pathology: Case Reports, Vol 22, Iss , Pp 200434- (2020)
Since the discovery of the ETV6-NTRK3 gene fusion in infantile fibrosarcoma two decades ago, it has become an important diagnostic marker because it is found in the majority of cases. However, the development of new molecular tests, including next ge
Externí odkaz:
https://doaj.org/article/7e38d56c477443c48ea4b44692cf3cfc
Autor:
Li Lei, Bradley A. Stohr, Stacey Berry, Christina M. Lockwood, Jessica L. Davis, Erin R. Rudzinski, Christian A. Kunder
Publikováno v:
Practical Laboratory Medicine, Vol 21, Iss , Pp e00164- (2020)
Objectives: To identify oncogenic driver mutations in congenital mesoblastic nephroma (CMN) cases lacking ETV6-NTRK3 fusion and discuss their diagnostic value. Design: The institutional pathology database was queried for cases with a morphologic diag
Externí odkaz:
https://doaj.org/article/5f0b58aa2adf416fa77fe42c06845580
Publikováno v:
Journal of Pediatric Surgery Case Reports, Vol 14, Iss C, Pp 29-31 (2016)
Necrotizing enterocolitis (NEC) is most often a disease of preterm infants, but can develop in full term infants with gastroschisis. The latter cases typically present later and have a milder clinical course; we present the first case of fatal Clostr
Externí odkaz:
https://doaj.org/article/192195682fc64f57aad40024e39dbbfc