Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jessica L. Counihan"'
Autor:
Justin A. De Leon, Jiazhang Qiu, Christopher J. Nicolai, Jessica L. Counihan, Kevin C. Barry, Li Xu, Rosalie E. Lawrence, Brian M. Castellano, Roberto Zoncu, Daniel K. Nomura, Zhao-Qing Luo, Russell E. Vance
Publikováno v:
Cell Reports, Vol 21, Iss 8, Pp 2031-2038 (2017)
All pathogens must acquire nutrients from their hosts. The intracellular bacterial pathogen Legionella pneumophila, the etiological agent of Legionnaires’ disease, requires host amino acids for growth within cells. The mechanistic target of rapamyc
Externí odkaz:
https://doaj.org/article/5471c9ca16a2435a881c2dc09deba9c1
Autor:
Daniel K. Nomura, Roberto Zoncu, Hijai R. Shin, Xuntian Jiang, Justin Zhang, Charles A. Berdan, Daniel S. Ory, Oliver B. Davis, Chun Yan Lim, Jessica L. Counihan
Publikováno v:
Nature cell biology
Cholesterol activates the master growth regulator, mTORC1 kinase, by promoting its recruitment to the surface of lysosomes by the Rag guanosine triphosphatases (GTPases). The mechanisms that regulate lysosomal cholesterol content to enable mTORC1 sig
Autor:
Jason R. Cannon, Regina F. Fernandez, Sora Q. Kim, Rachel M. Foguth, Jessica L. Counihan, Daniel K. Nomura, Yingwei Zhao, Marcus M. Weera, Julia A. Chester, Jessica M. Ellis
Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is highly abundant in the brain and confers protection against numerous neurological diseases, yet the fundamental mechanisms regulating the enrichment of DHA in the brain remain unknown. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b65111e61a2344e25d42a3b79b00130
https://europepmc.org/articles/PMC6298081/
https://europepmc.org/articles/PMC6298081/
Publikováno v:
Current Opinion in Chemical Biology. 30:68-76
A large number of pharmaceuticals, endogenous metabolites, and environmental chemicals act through covalent mechanisms with protein targets. Yet, their specific interactions with the proteome still remain poorly defined for most of these reactive che
Chemical genetics is a powerful approach for identifying therapeutically active small-molecules, but identifying the mechanisms of action underlying hit compounds remains challenging. Chemoproteomic platforms have arisen to tackle this challenge and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5984eb9fc7dd54196a466f7103f9caf7
https://europepmc.org/articles/PMC6389507/
https://europepmc.org/articles/PMC6389507/
Publikováno v:
Chemical reviews. 118(14)
Dysregulation of cancer cell metabolism contributes to abnormal cell growth, the biological end point of cancer. We review here numerous affected oncogenes and metabolic pathways common in cancer and how they contribute to cancer pathogenesis and mal
Autor:
Yingwei Zhao, Jessica M. Ellis, Jessica L. Counihan, Daniel K. Nomura, Julia A. Chester, Regina F. Fernandez
Publikováno v:
The FASEB Journal. 32
Autor:
Daniel K. Nomura, Zhao-Qing Luo, Li Xu, Russell E. Vance, Roberto Zoncu, Jessica L. Counihan, Justin A. De Leon, Brian M. Castellano, Rosalie E. Lawrence, Kevin C. Barry, Christopher J. Nicolai, Jiazhang Qiu
Publikováno v:
Cell reports, vol 21, iss 8
Cell Reports, Vol 21, Iss 8, Pp 2031-2038 (2017)
Cell Reports, Vol 21, Iss 8, Pp 2031-2038 (2017)
Summary All pathogens must acquire nutrients from their hosts. The intracellular bacterial pathogen Legionella pneumophila , the etiological agent of Legionnaires' disease, requires host amino acids for growth within cells. The mechanistic target of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e3858b0a68996e7087e5bc8427086b
https://escholarship.org/uc/item/6dr4t0z8
https://escholarship.org/uc/item/6dr4t0z8
Autor:
Daniel K. Nomura, Wan-min Ku, Leslie A. Bateman, Jessica L. Counihan, Karl Fisher, Megan Duckering, Esha D. Dalvie
Acetanilide herbicides are among the most widely used pesticides in the United States, but their toxicological potential and mechanisms remain poorly understood. Here, we have used chemoproteomic platforms to map proteome-wide cysteine reactivity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f9fe76de097c20ea9f5d6c113ecb63
https://europepmc.org/articles/PMC6376971/
https://europepmc.org/articles/PMC6376971/
Autor:
James A. Olzmann, Clark W.H. Peterson, Milton To, Mercedes S. Forster, Daniel K. Nomura, Tiffany Wu, Melissa A. Roberts, Jessica L. Counihan
Publikováno v:
Molecular biology of the cell, vol 28, iss 2
Molecular Biology of the Cell
Molecular Biology of the Cell
Lipid disequilibrium induced by inhibition of long-chain acyl-CoA synthetases impairs ERAD substrate glycan trimming and dislocation independently of its effects on lipid droplet biogenesis. The disruptions in ER proteostasis activate the IRE1 and PE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75e97a46359d1c30784dc667e5b04a2
https://escholarship.org/uc/item/1hh7031m
https://escholarship.org/uc/item/1hh7031m