Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jessica L. Brothwood"'
Autor:
Nicola S. Pether, Jessica L. Brothwood, Cornelis van Berkel, Elaine H. Dunwoodie, Robert L. Blake, Christopher P. Price, Richard G. Jones, Karl S. Baker, Geoff Hall
Publikováno v:
Practical Laboratory Medicine, Vol 9, Iss , Pp 45-52 (2017)
Objectives: Use of point-of-care testing is increasing, however many haematology analysers can only determine granulocyte count without further differentiation into neutrophils, eosinophils and basophils. Since the diagnosis of life-threatening neutr
Externí odkaz:
https://doaj.org/article/97715919c8e24e239c238c12c645bb55
Autor:
Nicola G. Wallis, Alison J.-A. Woolford, Nicola E. Wilsher, Neil T. Thompson, Lukas Stanczuk, Alpesh D. Shah, Caroline J. Richardson, Sharna J. Rich, David C. Rees, Michael Reader, Marc O'Reilly, David Norton, Christopher W. Murray, Sandra Muench, Vanessa Martins, John F. Lyons, Justyna Kucia-Tran, Christopher J. Hindley, Tom D. Heightman, Roberta Ferraldeschi, Charlotte East, Aurélie Courtin, Juan Castro, Jessica L. Brothwood, Luke Bevan, Valerio Berdini, Joanne M. Munck
Supplementary tables 1-6 summarise the kinase panel screen data (1) mouse PK parameters (2) and further details of the anti-tumour activity (5) conferred by ASTX029, plus details of cell lines used in this study (3 and 4) and further details of the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c83a97aa3dd2ed35fbdc9ef36e9bb5
https://doi.org/10.1158/1535-7163.22521489.v1
https://doi.org/10.1158/1535-7163.22521489.v1
Autor:
Nicola G. Wallis, Alison J.-A. Woolford, Nicola E. Wilsher, Neil T. Thompson, Lukas Stanczuk, Alpesh D. Shah, Caroline J. Richardson, Sharna J. Rich, David C. Rees, Michael Reader, Marc O'Reilly, David Norton, Christopher W. Murray, Sandra Muench, Vanessa Martins, John F. Lyons, Justyna Kucia-Tran, Christopher J. Hindley, Tom D. Heightman, Roberta Ferraldeschi, Charlotte East, Aurélie Courtin, Juan Castro, Jessica L. Brothwood, Luke Bevan, Valerio Berdini, Joanne M. Munck
Supplementary figures 1-7 show the effects of AST029 on ERK signalling in RAS-mutant cell lines (1) and tumour xenograft tissue (3), ASTX029 plasma PK linearity (2), ASTX029 activity in a cell line panel showing MAPK mutation status (4) the effects o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185aef78c19fca4a606a8b2c178f1341
https://doi.org/10.1158/1535-7163.22521498.v1
https://doi.org/10.1158/1535-7163.22521498.v1
Autor:
Neil T. Thompson, Nicola G. Wallis, Michael Reader, Christopher J. Hindley, Juan Castro, John Lyons, David C. Rees, Nicola E. Wilsher, Caroline Richardson, Tom D. Heightman, Lukas Stanczuk, Alpesh Shah, Sharna J. Rich, Charlotte East, Valerio Berdini, Marc O'Reilly, Justyna Kucia-Tran, Jessica L. Brothwood, Joanne M. Munck, Alison Jo-Anne Woolford, Sandra Muench, Christopher William Murray, David Norton, Luke Bevan, Aurélie Courtin, Roberta Ferraldeschi, Vanessa Martins
Publikováno v:
Molecular Cancer Therapeutics. 20:1757-1768
The MAPK signaling pathway is commonly upregulated in human cancers. As the primary downstream effector of the MAPK pathway, ERK is an attractive therapeutic target for the treatment of MAPK-activated cancers and for overcoming resistance to upstream
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6856599564530823950e091fd6e69a67
https://doi.org/10.1158/1535-7163.mct-20-0909
https://doi.org/10.1158/1535-7163.mct-20-0909
Autor:
Geoff Hall, Karl S. Baker, Nicola S. Pether, Robert L. Blake, Christopher P. Price, Jessica L. Brothwood, Elaine H. Dunwoodie, Richard G. Jones, Cees van Berkel
Publikováno v:
Practical Laboratory Medicine
Practical Laboratory Medicine, Vol 9, Iss, Pp 45-52 (2017)
Practical Laboratory Medicine, Vol 9, Iss, Pp 45-52 (2017)
Objectives: Use of point-of-care testing is increasing, however many haematology analysers can only determine granulocyte count without further differentiation into neutrophils, eosinophils and basophils. Since the diagnosis of life-threatening neutr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0e56f61d05e482b94d8198f0279ec3
https://eprints.whiterose.ac.uk/122202/1/1-s2.0-S2352551717300276-main.pdf
https://eprints.whiterose.ac.uk/122202/1/1-s2.0-S2352551717300276-main.pdf