Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jessica L. Bridgford"'
Autor:
Jessica L. Bridgford, Stanley C. Xie, Simon A. Cobbold, Charisse Flerida A. Pasaje, Susann Herrmann, Tuo Yang, David L. Gillett, Lawrence R. Dick, Stuart A. Ralph, Con Dogovski, Natalie J. Spillman, Leann Tilley
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Artemisinin (ART) is a widely used antimalarial drug, but its mechanism of action is poorly understood. Here, Bridgford et al. show that ART kills parasites by a two-pronged mechanism, causing protein damage and compromising proteasome function, and
Externí odkaz:
https://doaj.org/article/65e9ecff6a5e4bf9bde0b3289d249518
Autor:
Moore Z. Chen, Nagaraj S. Moily, Jessica L. Bridgford, Rebecca J. Wood, Mona Radwan, Trevor A. Smith, Zhegang Song, Ben Zhong Tang, Leann Tilley, Xiaohong Xu, Gavin E. Reid, Mahmoud A. Pouladi, Yuning Hong, Danny M. Hatters
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Proteostasis is maintained through a number of molecular mechanisms, some of which function to protect the folded state of proteins. Here the authors demonstrate the use of TPE-MI in a fluorigenic dye assay for the quantitation of unfolded proteins t
Externí odkaz:
https://doaj.org/article/a4333004f228480fbf7846ca619a3233
Autor:
Tuo Yang, Lee M. Yeoh, Madel V. Tutor, Matthew W. Dixon, Paul J. McMillan, Stanley C. Xie, Jessica L. Bridgford, David L. Gillett, Michael F. Duffy, Stuart A. Ralph, Malcolm J. McConville, Leann Tilley, Simon A. Cobbold
Publikováno v:
Cell Reports, Vol 29, Iss 9, Pp 2917-2928.e5 (2019)
Summary: Increased tolerance of Plasmodium falciparum to front-line artemisinin antimalarials (ARTs) is associated with mutations in Kelch13 (K13), although the precise role of K13 remains unclear. Here, we show that K13 mutations result in decreased
Externí odkaz:
https://doaj.org/article/8f39fae61eff431d8f068b8099d6e17e
Autor:
Sergio Wittlin, Sachel Mok, Benoît Laleu, Anwu Zhou, Susan A. Charman, Margaret A. Phillips, Tomas Yeo, David A. Fidock, Alisje Churchyard, Joseph M. Ready, Francisco-Javier Gamo, Ioanna Deni, John Okombo, Bruce A. Posner, Aloysus K. Lawong, Jessica L. Bridgford, Elizabeth A. Winzeler, Benigno Crespo, Michael J. Palmer, Hanspeter Niederstrasser, Josefine Striepen, Suraksha Gahalawat, Jake Baum, Nimisha Mittal
Publikováno v:
Journal of Medicinal Chemistry. 64:2739-2761
Malaria control programs continue to be threatened by drug resistance. To identify new antimalarials, we conducted a phenotypic screen and identified a novel tetrazole-based series that shows fast-kill kinetics and a relatively low propensity to deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c2c4959d61f50243834064afd89e585
https://doi.org/10.1021/acs.jmedchem.0c02022
https://doi.org/10.1021/acs.jmedchem.0c02022
Autor:
Andrew J. Brooks, Mario Cazzola, Jessica L. Bridgford, Matthew E. Call, Melissa J. Call, Alan F. Rubin, Elisa Rumi, Su Min Lee, Daniela Pietra, Stephen Wilcox, Paola Guglielmelli, Christine M. M. Lee, Alessandro M. Vannucchi, Yash Chhabra
Publikováno v:
Blood. 135:287-292
The single transmembrane domain (TMD) of the human thrombopoietin receptor (TpoR/myeloproliferative leukemia [MPL] protein), encoded by exon 10 of the MPL gene, is a hotspot for somatic mutations associated with myeloproliferative neoplasms (MPNs). A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd5534c01fb77a314a6116ae34ab8a5b
https://doi.org/10.1182/blood.2019002561
https://doi.org/10.1182/blood.2019002561
Autor:
Maria G. Gomez-Lorenzo, Francisco-Javier Gamo, Claire Le Manach, Daniel E. Goldberg, Gavreel Kalantarov, Manu Vanaerschot, Anna Y. Burkhard, Jacquin C. Niles, Ioanna Deni, Olivia Coburn-Flynn, Jessica L. Bridgford, Tomoyo Sakata-Kato, Annie N. Cowell, Tomas Yeo, Rachel L. Edwards, Audrey R. Odom John, Sabine Ottilie, Charisse Flerida A. Pasaje, Ilya Trakht, Maëlle Duffey, Elizabeth A. Winzeler, Sachel Mok, Benoît Laleu, Sumanta Dey, Kelly Chibale, David A. Fidock, Kathryn J. Wicht, James M. Murithi, Amanda K. Lukens, Nina F. Gnädig, John Okombo, Dyann F. Wirth, Eva S. Istvan
Publikováno v:
Cell chemical biology. 29(5)
Summary Widespread Plasmodium falciparum resistance to first-line antimalarials underscores the vital need to develop compounds with novel modes of action and identify new druggable targets. Here, we profile five compounds that potently inhibit P. fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6be8eb9d83e2bdd5a4392c2076fbbc0
https://pubmed.ncbi.nlm.nih.gov/34233174
https://pubmed.ncbi.nlm.nih.gov/34233174
Autor:
Aloysus, Lawong, Suraksha, Gahalawat, John, Okombo, Josefine, Striepen, Tomas, Yeo, Sachel, Mok, Ioanna, Deni, Jessica L, Bridgford, Hanspeter, Niederstrasser, Anwu, Zhou, Bruce, Posner, Sergio, Wittlin, Francisco Javier, Gamo, Benigno, Crespo, Alisje, Churchyard, Jake, Baum, Nimisha, Mittal, Elizabeth, Winzeler, Benoît, Laleu, Michael J, Palmer, Susan A, Charman, David A, Fidock, Joseph M, Ready, Margaret A, Phillips
Publikováno v:
J Med Chem
Malaria control programs continue to be threatened by drug resistance. To identify new antimalarials we conducted a phenotypic screen and identified a novel tetrazole-based series that shows fast-kill kinetics and a relatively low propensity to devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::994107cef90e797b907ca201390d2209
https://pubmed.ncbi.nlm.nih.gov/33620219
https://pubmed.ncbi.nlm.nih.gov/33620219
Autor:
Stuart A. Ralph, Leann Tilley, Simon A. Cobbold, Tuo Yang, Susann Herrmann, Natalie J. Spillman, Stanley C. Xie, Charisse Flerida A. Pasaje, Lawrence R. Dick, Jessica L. Bridgford, Con Dogovski, David L. Gillett
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Artemisinin and its derivatives (collectively referred to as ARTs) rapidly reduce the parasite burden in Plasmodium falciparum infections, and antimalarial control is highly dependent on ART combination therapies (ACTs). Decreased sensitivity to ARTs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53cdd3828f59e2934aea31468a1d6c68
https://doaj.org/article/65e9ecff6a5e4bf9bde0b3289d249518
https://doaj.org/article/65e9ecff6a5e4bf9bde0b3289d249518
Autor:
Mahmoud A. Pouladi, Ben Zhong Tang, Danny M. Hatters, Leann Tilley, Zhegang Song, Rebecca J. Wood, Nagaraj S. Moily, Gavin E. Reid, Moore Z. Chen, Mona Radwan, Jessica L. Bridgford, Trevor A. Smith, Yuning Hong, Xiaohong Xu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Nature Communications
Nature Communications
When proteostasis becomes unbalanced, unfolded proteins can accumulate and aggregate. Here we report that the dye, tetraphenylethene maleimide (TPE-MI) can be used to measure cellular unfolded protein load. TPE-MI fluorescence is activated upon label
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79aff6df61326bd68164f5220ecb2516
http://link.springer.com/article/10.1038/s41467-017-00203-5
http://link.springer.com/article/10.1038/s41467-017-00203-5
Autor:
Malcolm J. McConville, Madel V Tutor, Matthew W. A. Dixon, Paul J. McMillan, Stuart A. Ralph, Stanley C. Xie, Lee M. Yeoh, David L. Gillett, Tuo Yang, Jessica L. Bridgford, Leann Tilley, Michael F. Duffy, Simon A. Cobbold
Publikováno v:
Cell Reports, Vol 29, Iss 9, Pp 2917-2928.e5 (2019)
Summary: Increased tolerance of Plasmodium falciparum to front-line artemisinin antimalarials (ARTs) is associated with mutations in Kelch13 (K13), although the precise role of K13 remains unclear. Here, we show that K13 mutations result in decreased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5f609b0d2b48f77b6ac5d5cf6db837
https://pubmed.ncbi.nlm.nih.gov/31775055
https://pubmed.ncbi.nlm.nih.gov/31775055