Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Jessica L. Braun"'
Autor:
Jessica L. Braun, Val A. Fajardo
Publikováno v:
npj Microgravity, Vol 10, Iss 1, Pp 1-7 (2024)
Abstract Spending time in a microgravity environment is known to cause significant skeletal muscle atrophy and weakness via muscle unloading, which can be partly attributed to Ca2+ dysregulation. The sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) p
Externí odkaz:
https://doaj.org/article/b00a9b7d23d944e18a8f7f68b9072c68
Autor:
Kevin Li, Riya Desai, Ryan T. Scott, Joel Ricky Steele, Meera Machado, Samuel Demharter, Adrienne Hoarfrost, Jessica L. Braun, Val A. Fajardo, Lauren M. Sanders, Sylvain V. Costes
Publikováno v:
npj Microgravity, Vol 9, Iss 1, Pp 1-10 (2023)
Abstract The adverse effects of microgravity exposure on mammalian physiology during spaceflight necessitate a deep understanding of the underlying mechanisms to develop effective countermeasures. One such concern is muscle atrophy, which is partly a
Externí odkaz:
https://doaj.org/article/7dfdaa21df6f4caa8a95866e17922a9f
Publikováno v:
Biomolecules, Vol 14, Iss 6, p 675 (2024)
Risk of cardiovascular disease mortality rises in women after menopause. While increased cardiovascular risk is largely attributed to postmenopausal declines in estrogens, the molecular changes in the heart that contribute to risk are poorly understo
Externí odkaz:
https://doaj.org/article/7a7e5f88eb664a5f8baf35f1a8a0b9f4
Autor:
Ryan W. Baranowski, Jessica L. Braun, Briana L. Hockey, Jenalyn L. Yumol, Mia S. Geromella, Colton J.F. Watson, Nigel Kurgan, Holt N. Messner, Kennedy C. Whitley, Adam J. MacNeil, Guillemette Gauquelin-Koch, Fabrice Bertile, William Gittings, Rene Vandenboom, Wendy E. Ward, Val A. Fajardo
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107047- (2023)
Summary: We examined the effects of ∼30 days of spaceflight on glycogen synthase kinase 3 (GSK3) content and inhibitory serine phosphorylation in murine muscle and bone samples from four separate missions (BION-M1, rodent research [RR]1, RR9, and R
Externí odkaz:
https://doaj.org/article/e4d4f424c12d421f9b505e655757ff9a
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 101987- (2023)
Summary: This protocol employs the indo-1 Ca2+ fluorophore to quantify Ca2+ uptake by the sarco(endo)plasmic reticulum Ca2+ ATPase pump in murine muscle homogenates and allows for real-time kinetic measurement of Ca2+ mobilization within the muscle h
Externí odkaz:
https://doaj.org/article/92f19cc60da347b08ebe330e852ef394
Autor:
Jessica L. Braun, Jisook Ryoo, Kyle Goodwin, Emily N. Copeland, Mia S. Geromella, Ryan W. Baranowski, Rebecca E. K. MacPherson, Val A. Fajardo
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/3d679120a1b246c2b5485b6acc67d0ff
Autor:
Riley E.G. Cleverdon, Jessica L. Braun, Mia S. Geromella, Kennedy C. Whitley, Daniel M. Marko, Sophie I. Hamstra, Brian D. Roy, Rebecca E.K. MacPherson, Val A. Fajardo
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104972- (2022)
Summary: The DBA/2J (D2) mdx mouse is a more severe model of Duchenne muscular dystrophy when compared to the traditional C57BL/10 (C57) mdx mouse. Here, we questioned whether sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) function would differ in
Externí odkaz:
https://doaj.org/article/50106664f0bf4e4cadafde9a1a5cf723
Autor:
Jessica L. Braun, Jisook Ryoo, Kyle Goodwin, Emily N. Copeland, Mia S. Geromella, Ryan W. Baranowski, Rebecca E. K. MacPherson, Val A. Fajardo
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
The sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) pump is responsible for the transport of Ca2+ from the cytosol into the sarcoplasmic reticulum at the expense of ATP, making it a regulator of both muscle relaxation and muscle-based energy expendi
Externí odkaz:
https://doaj.org/article/07c4ea9de3d74b558c00ba4a05fe44e9
Autor:
Jessica L. Braun, Holt N. Messner, Riley E. G. Cleverdon, Ryan W. Baranowski, Sophie I. Hamstra, Mia S. Geromella, Jeffrey A. Stuart, Val A. Fajardo
Publikováno v:
Physiological Reports, Vol 10, Iss 10, Pp n/a-n/a (2022)
Abstract The sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) restores intracellular Ca2+ ([Ca2+]i) to resting levels after muscle contraction, ultimately eliciting relaxation. SERCA pumps are highly susceptible to tyrosine (T)‐nitration, impairing
Externí odkaz:
https://doaj.org/article/031c24bbc2354d519fa7a191f0b7a432
Publikováno v:
FASEB BioAdvances, Vol 2, Iss 10, Pp 579-586 (2020)
Abstract Neuronatin (NNAT) was originally discovered in 1995 and labeled as a brain developmental gene due to its abundant expression in developing brains. Over the past 25 years, researchers have uncovered NNAT in other tissues; notably, the hypotha
Externí odkaz:
https://doaj.org/article/a4d84decad0746559eb60bab9f834107