Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Jessica L. Bolton"'
Autor:
Annabel K. Short, Christina W. Thai, Yuncai Chen, Noriko Kamei, Aidan L. Pham, Matthew T. Birnie, Jessica L. Bolton, Ali Mortazavi, Tallie Z. Baram
Publikováno v:
Biological Psychiatry Global Open Science, Vol 3, Iss 1, Pp 99-109 (2023)
Background: Mental health and vulnerabilities to neuropsychiatric disorders involve the interplay of genes and environment, particularly during sensitive developmental periods. Early-life adversity (ELA) and stress promote vulnerabilities to stress-r
Externí odkaz:
https://doaj.org/article/36084c5dad3d4921b7406a533444ff1b
Autor:
Sophia C. Levis, Matthew T. Birnie, Jessica L. Bolton, Christina R. Perrone, Johanna S. Montesinos, Tallie Z. Baram, Stephen V. Mahler
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract In humans, early-life adversity (ELA) such as trauma, poverty, and chaotic environment is linked to increased risk of later-life emotional disorders including depression and substance abuse. These disorders involve underlying disruption of r
Externí odkaz:
https://doaj.org/article/7d5c93c12e2b45248d0c2fbc5210959f
Sex-specific behavioral outcomes of early-life adversity and emerging microglia-dependent mechanisms
Autor:
Madison M. Garvin, Jessica L. Bolton
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 16 (2022)
Early-life adversity (ELA) is known to alter brain circuit maturation as well as increase vulnerability to cognitive and emotional disorders. However, the importance of examining sex as a biological variable when researching the effects of ELA has no
Externí odkaz:
https://doaj.org/article/bd99926aee2941e09184a6bcdbf70897
Autor:
Zuri Ngozi, Jessica L. Bolton
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Microglia are now well-known as integral regulators of brain development, phagocytosing whole neurons, and pruning weak or excess synapses in order to sculpt and refine immature circuits. However, the importance of neuronal subtype in guiding microgl
Externí odkaz:
https://doaj.org/article/e96b7328cd3c4fdcb5902446523ada2b
Autor:
Jessica L. Bolton, Anton Schulmann, Megan M. Garcia-Curran, Limor Regev, Yuncai Chen, Noriko Kamei, Manlin Shao, Akanksha Singh-Taylor, Shan Jiang, Yoav Noam, Jenny Molet, Ali Mortazavi, Tallie Z. Baram
Publikováno v:
Cell Reports, Vol 33, Iss 11, Pp 108511- (2020)
Summary: Early-life adversity (ELA) is associated with lifelong memory deficits, yet the responsible mechanisms remain unclear. We impose ELA by rearing rat pups in simulated poverty, assess hippocampal memory, and probe changes in gene expression, t
Externí odkaz:
https://doaj.org/article/4bf6ad0ca44047a889a6263685153df9
Autor:
Agbonlahor Okhuarobo, Jessica L. Bolton, Ighodaro Igbe, Eric P. Zorrilla, Tallie Z. Baram, Candice Contet
Publikováno v:
Neurobiology of Stress, Vol 13, Iss , Pp 100269- (2020)
Childhood adversity increases vulnerability to alcohol use disorders and preclinical models are needed to investigate the underlying neurobiological mechanisms. The present study modeled early-life adversity by rearing male and female C57BL/6J mouse
Externí odkaz:
https://doaj.org/article/f7b43133f4b74727bcb44756234d5698
Autor:
Jessica L. Bolton, Christina M. Ruiz, Neggy Rismanchi, Gissell A. Sanchez, Erik Castillo, Jeff Huang, Christopher Cross, Tallie Z. Baram, Stephen V. Mahler
Publikováno v:
Neurobiology of Stress, Vol 8, Iss , Pp 57-67 (2018)
Early-life adversity increases the risk for emotional disorders such as depression and schizophrenia. Anhedonia, thought to be a core feature of these disorders, is provoked by our naturalistic rodent model of childhood adversity (i.e., rearing pups
Externí odkaz:
https://doaj.org/article/fa1b5e4e6e9348a1937073adc387e747
Autor:
Jessica L. Bolton, Annabel Katherine Short, Kristina A. Simeone, Jennifer Daglian, Tallie Z. Baram
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 13 (2019)
Early-life experiences influence brain structure and function long-term, contributing to resilience or vulnerability to stress and stress-related disorders. Therefore, understanding the mechanisms by which early-life experiences program specific brai
Externí odkaz:
https://doaj.org/article/77aaefbdf0c94112899cc1a5e131022f
Autor:
Jessica L. Bolton, Steven Marinero, Tania Hassanzadeh, Divya Natesan, Dominic Le, Christine Belliveau, S. N. Mason, Richard L. Auten, Staci D. Bilbo
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 9 (2017)
Microglia are the resident immune cells of the brain, important for normal neural development in addition to host defense in response to inflammatory stimuli. Air pollution is one of the most pervasive and harmful environmental toxicants in the moder
Externí odkaz:
https://doaj.org/article/888b4e0c33674366ac3e7751a9be3473
Autor:
Agbonlahor Okhuarobo, Maggie Angelo, Jessica L. Bolton, Catherine Lopez, Ighodaro Igbe, Tallie Z. Baram, Candice Contet
Publikováno v:
Alcohol: Clinical and Experimental Research. 47:336-347
Stressful early-life experiences increase the risk of developing an alcohol use disorder. We had previously found that male C57BL/6J mice reared under limited bedding and nesting (LBN) conditions, a model of early-life adversity, escalate their ethan