Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jessica L Saulnier"'
Autor:
Lynne Chantranupong, Jessica L Saulnier, Wengang Wang, Drew R Jones, Michael E Pacold, Bernardo L Sabatini
Publikováno v:
eLife, Vol 9 (2020)
Neurons communicate by the activity-dependent release of small-molecule neurotransmitters packaged into synaptic vesicles (SVs). Although many molecules have been identified as neurotransmitters, technical limitations have precluded a full metabolomi
Externí odkaz:
https://doaj.org/article/d6079662b5df464a9044491aa0a94a6d
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105584 (2014)
The prokaryotic adaptive immune system CRISPR/Cas9 has recently been adapted for genome editing in eukaryotic cells. This technique allows for sequence-specific induction of double-strand breaks in genomic DNA of individual cells, effectively resulti
Externí odkaz:
https://doaj.org/article/348d3d465dc743b6ace911d8002cbb2d
Publikováno v:
Frontiers in Neural Circuits, Vol 17 (2023)
Acetylcholine and GABA are often co-released, including from VIP-expressing neurons of the cortex, cortically-projecting neurons of the globus pallidus externus and basal forebrain, and hippocampal-projecting neurons of the medial septum. The co-rele
Externí odkaz:
https://doaj.org/article/87c9ebb68f194a7d8935344b64be0fed
Autor:
Michael E. Pacold, Jessica L. Saulnier, Bernardo L. Sabatini, Wengang Wang, Lynne Chantranupong, Drew R. Jones
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Neurons communicate by the activity-dependent release of small-molecule neurotransmitters packaged into synaptic vesicles (SVs). Although many molecules have been identified as neurotransmitters, technical limitations have precluded a full metabolomi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66cc6cac391c4ca3dec326ef680739e
http://europepmc.org/articles/PMC7575323
http://europepmc.org/articles/PMC7575323
Autor:
Aurélien Bègue, Christoph Straub, Bernardo L. Sabatini, Kee Wui Huang, Danielle Feng, Jessica L. Saulnier
Publikováno v:
Neuron. 92:84-92
The striatum, the entry nucleus of the basal ganglia, lacks laminar or columnar organization of its principal cells; nevertheless, functional data suggest that it is spatially organized. Here we examine whether the connectivity and synaptic organizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb8e8941d03021550fd7dc8fcb83024
https://doi.org/10.1016/j.neuron.2016.09.007
https://doi.org/10.1016/j.neuron.2016.09.007
Autor:
Nikita Pak, Mikhail Drobizhev, Jeffrey L. Rhoades, Jessica L. Saulnier, Demian Park, Shoh Asano, Clemens Riegler, Edward S. Boyden, Misha B. Ahrens, Florian Engert, Young-Gyu Yoon, Ho-Jun Suk, Daniel Hochbaum, Changyang Linghu, Takashi Kawashima, Eftychios A. Pnevmatikakis, Steven W. Flavell, Kiryl D. Piatkevich, Daniel Goodwin, Bálint Szabó, Erica E. Jung, Chao-Tsung Yang, Limor Freifeld, Bernardo L. Sabatini, Or A. Shemesh, Thomas E. Hughes, Christoph Straub
Publikováno v:
Nature chemical biology
We here present a new way to engineer complex proteins toward multidimensional specifications, through a simple yet scalable directed evolution strategy. By robotically picking mammalian cells that are identified, under a microscope, to express prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f229a6f4e28ffef4208561daa8a9d9f
https://pubmed.ncbi.nlm.nih.gov/29520042
https://pubmed.ncbi.nlm.nih.gov/29520042
Autor:
Venkatesh N. Murthy, D. Jed Harrison, Adam E. Cohen, Yongxin Zhao, Gabriella L. Boulting, Edward S. Boyden, Dougal Maclaurin, Robert E. Campbell, Peng Zou, Daniel Hochbaum, Jessica L. Saulnier, Samouil L. Farhi, Bernardo L. Sabatini, Christoph Straub, Joel M. Kralj, Niklas Smedemark-Margulies, Nathan C. Klapoetke, Gane Ka-Shu Wong, Christopher A. Werley, Michael Melkonian, Vikrant Kapoor, Yong Ku Cho
Publikováno v:
Nature methods
PMC
PMC
All-optical electrophysiology—spatially resolved simultaneous optical perturbation and measurement of membrane voltage—would open new vistas in neuroscience research. We evolved two archaerhodopsin-based voltage indicators, QuasAr1 and 2, which s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6427126200a679e024a3f90d75b13ea
https://doi.org/10.1038/nmeth.3000
https://doi.org/10.1038/nmeth.3000
Autor:
Howard L. Weiner, Dennis J. Selkoe, Shaomin Li, Lior Mayo, Thomas Koeglsperger, Christian Brenneis, Yijun Carrier, Jessica L. Saulnier
Publikováno v:
Glia. 61:985-1002
Transforming growth factor β1 (TGF-β1) is a pleiotropic cytokine expressed throughout the CNS. Previous studies demonstrated that TGF-β1 contributes to maintain neuronal survival, but mechanistically this effect is not well understood. We generate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ece3931c29ac54981e2366429b6c388b
https://doi.org/10.1002/glia.22490
https://doi.org/10.1002/glia.22490
Autor:
Adam J. Granger, Yao Chen, Jessica L. Saulnier, Bernardo L. Sabatini, Trinh T. Tran, Alfredo Kirkwood
Publikováno v:
Neuron. 96(5)
Protein kinase A (PKA) integrates inputs from G-protein-coupled neuromodulator receptors to modulate synaptic and cellular function. Gαs signaling stimulates PKA activity, whereas Gαi inhibits PKA activity. Gαq, on the other hand, signals through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f90c9836f152c06af65e12b450b91d5
https://pubmed.ncbi.nlm.nih.gov/29154125
https://pubmed.ncbi.nlm.nih.gov/29154125