Zobrazeno 1 - 10 of 31 pro vyhledávání: '"Jessica L Rouge"'
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Akademický článek
Viral Mimicry as a Design Template for Nucleic Acid Nanocarriers
Autor: Ina F. de la Fuente, Shraddha S. Sawant, Mark Q. Tolentino, Patrick M. Corrigan, Jessica L. Rouge
Publikováno v: Frontiers in Chemistry, Vol 9 (2021)
Therapeutic nucleic acids hold immense potential in combating undruggable, gene-based diseases owing to their high programmability and relative ease of synthesis. While the delivery of this class of therapeutics has successfully entered the clinical
Externí odkaz: https://doaj.org/article/ddd4d3f7cb504ca0a9bf8c185f64f1e8
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A GATA3 Targeting Nucleic Acid Nanocapsule for In Vivo Gene Regulation in Asthma
Autor: Tyler D Gavitt, Jessica L. Rouge, Steven M. Szczepanek, Arlind B Mara, Alyssa K. Hartmann, Shraddha S. Sawant
Publikováno v: ACS Nano. 15:11192-11201
Allergic asthma is one of the leading chronic lung diseases of both children and adults worldwide, resulting in significant morbidity and mortality in affected individuals. Many patients have severe asthma, which is refractory to treatment, illustrat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff0c1a3163cddcff640d22ed7f05c832
https://doi.org/10.1021/acsnano.0c07781
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A thermoresponsive crosslinker for reversible micelle stabilization
Autor: Mark Q. Tolentino, Jessica L. Rouge
Publikováno v: Materials Advances. 2:2267-2271
Herein we report a thermoresponsive crosslinker that can be utilized to stabilize the surface of micelles through a “click” reaction and to trigger the disassembly via a retro Diels Alder (rDA) mechanism. The micelles generated were 100 nm in siz
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65ad5e7e7ae490367c16299bf89f590b
https://doi.org/10.1039/d1ma00089f
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6
Chimeric siRNA-DNA Surfactants for the Enhanced Delivery and Sustained Cytotoxicity of a Gold(III) Metallodrug
Autor: Jessica L. Rouge, Luca Ronconi, Andrea Pettenuzzo, Alyssa K. Hartmann, Saketh Gudipati
Publikováno v: Bioconjugate Chemistry. 31:1063-1069
Using a recently developed nucleic acid delivery platform, we demonstrate the effective delivery of metallodrug [AuIIIBr2(SSC-Inp-OEt)] (AP228; Inp = isonipecotic moiety), a hydrophobic, low solubility gold complex cytotoxic to cancer cells. It is sh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b75d8cccfb3c62384cdef3251260bbbf
https://doi.org/10.1021/acs.bioconjchem.0c00047
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Tracking nucleic acid nanocapsule assembly, cellular uptake and disassembly using a novel fluorescently labeled surfactant
Autor: Arifuzzaman, Alyssa K. Hartmann, Jessica L. Rouge
Publikováno v: RSC Advances. 10:42349-42353
Intracellular trafficking and delivery of nucleic acids is an area of growing interest, particularly as it relates to therapeutic applications. Spectroscopic methods have been used to observe and quantitatively measure the delivery of oligonucleotide
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6f504584f5323d96b7d587f396a5ee
https://doi.org/10.1039/d0ra09472b
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8
Multi-layered stimuli responsive DNA micelles for the stepwise controlled release of small molecules
Autor: Joshua J. Santiana, Shraddha S. Sawant, Nicole Gomez, Jessica L. Rouge
Publikováno v: Journal of materials chemistry. B. 10(37)
Controllable release of multiple distinct cargoes from a nanomaterial is crucial to a variety of therapeutic and catalytic applications. In this study, we describe a DNA functionalized multi-layered surface crosslinked micelle (mlSCM) consisting of i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f158043e0a031368293414708033fee8
https://pubmed.ncbi.nlm.nih.gov/35224590
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