Výsledky vyhledávání - "Jessica L Dunlop"

Nanobodies identify an activated state of the TRIB2 pseudokinase

Autor: Sam A. Jamieson, Michael Pudjihartono, Christopher R. Horne, Juan Salamanca Viloria, Jessica L. Dunlop, Hamish D. McMillan, Robert C. Day, Karen Keeshan, James M. Murphy, Peter D. Mace

Publikováno v: Structure (London, England : 1993). 30(11)

Tribbles proteins (TRIB1-3) are pseudokinases that recruit substrates to the COP1 ubiquitin ligase. TRIB2 was the first Tribbles ortholog to be implicated as a myeloid leukemia oncogene, because it recruits the C/EBPα transcription factor for ubiqui

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e69107dc5d7d61022cfb0a2aea52fb3
https://pubmed.ncbi.nlm.nih.gov/36332608

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Serotonin type-3 receptor antagonists selectively kill melanoma cells through classical apoptosis, microtubule depolymerisation, ERK activation, and NF-κB downregulation

Autor: Anita Barzegar-Fallah, Sarah K. Baird, Jessica L Dunlop, Elham Torbati, Houman Alimoradi

Publikováno v: Cell Biology and Toxicology.

Malignant melanoma is a highly metastatic tumour, resistant to treatment. Serotonin type-3 (5-HT3) receptor antagonists, such as tropisetron and ondansetron, are well-tolerated antiemetic drugs commonly used to prevent nausea caused by chemotherapy o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2eca4babb69bd4e595dd8c642ed2dab
https://doi.org/10.1007/s10565-021-09667-0

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