Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Jessica L Davies"'
1
Akademický článek
Increased THEMIS First Exon Usage in CD4+ T-Cells Is Associated with a Genotype that Is Protective against Multiple Sclerosis.
Autor: Jessica L Davies, Sara Thompson, Harpreet Kaur-Sandhu, Stephen Sawcer, Alasdair Coles, Maria Ban, Joanne Jones
Publikováno v: PLoS ONE, Vol 11, Iss 7, p e0158327 (2016)
Multiple sclerosis is an autoimmune disease of the central nervous system. Genome wide association studies have identified over 100 common variants associated with multiple sclerosis, the majority of which implicate immunologically relevant genes, pa
Externí odkaz: https://doaj.org/article/ba17d79309fa4e63ab24edbe054cc384
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2
Akademický článek
Mouse fetal growth restriction through parental and fetal immune gene variation and intercellular communications cascade
Autor: Gurman Kaur, Caroline B. M. Porter, Orr Ashenberg, Jack Lee, Samantha J. Riesenfeld, Matan Hofree, Maria Aggelakopoulou, Ayshwarya Subramanian, Subita Balaram Kuttikkatte, Kathrine E. Attfield, Christiane A. E. Desel, Jessica L. Davies, Hayley G. Evans, Inbal Avraham-Davidi, Lan T. Nguyen, Danielle A. Dionne, Anna E. Neumann, Lise Torp Jensen, Thomas R. Barber, Elizabeth Soilleux, Mary Carrington, Gil McVean, Orit Rozenblatt-Rosen, Aviv Regev, Lars Fugger
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-25 (2022)
Natural Killer cells regulate foetal growth. Here the authors use a humanized transgenic mouse to demonstrate that specific HLA-C KIR2DL interactions promote changes in maternal and foetal cell transcriptomes, resulting in modifications to placental
Externí odkaz: https://doaj.org/article/2d63981d766b447aaf8cd3b6178c97fc
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3
Akademický článek
Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73
Autor: Lorna B. Jarvis, Daniel B. Rainbow, Valerie Coppard, Sarah K. Howlett, Zoya Georgieva, Jessica L. Davies, Harpreet Kaur Mullay, Joanna Hester, Tom Ashmore, Aletta Van Den Bosch, James T. Grist, Alasdair J. Coles, Hani S. Mousa, Stefano Pluchino, Krishnaa T. Mahbubani, Julian L. Griffin, Kourosh Saeb-Parsy, Fadi Issa, Luca Peruzzotti-Jametti, Linda S. Wicker, Joanne L. Jones
Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Jarvis et al demonstrate that expanded human Tregs switch their metabolism to aerobic glycolysis and show enhanced suppressive function through hypoxia-inducible factor 1-alpha (HIF1A)-driven acquisition of CD73 expression, which along with CD39, ena
Externí odkaz: https://doaj.org/article/45140660645e4b33867eb3d5efef93f6
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4
Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73
Autor: Daniel B. Rainbow, Lorna B. Jarvis, Valerie Coppard, Hani S Mousa, Joanne L. Jones, Alasdair Coles, Zoya Georgieva, Fadi Issa, Kourosh Saeb-Parsy, Krishnaa T. Mahbubani, Stefano Pluchino, Tom Ashmore, Sarah Howlett, Julian L. Griffin, Luca Peruzzotti-Jametti, Linda S. Wicker, Aletta Van Den Bosch, Joanna Hester, Harpreet Kaur Mullay, James T. Grist, Jessica L. Davies
Publikováno v: Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
The adoptive transfer of regulatory T-cells (Tregs) is a promising therapeutic approach in transplantation and autoimmunity. However, because large cell numbers are needed to achieve a therapeutic effect, in vitro expansion is required. By comparing
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bbb0f51688879fe919b945878fdba9a
https://pubmed.ncbi.nlm.nih.gov/34650224
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7
Human autoimmunity after lymphocyte depletion is caused by homeostatic T-cell proliferation
Autor: Priscilla Loh, Alastair Compston, Sara A. J. Thompson, Joanne L. Jones, Grant A. Hill-Cawthorne, Allison J. Curry, Jessica L. Davies, Michael T. Fahey, Laura Azzopardi, Alasdair Coles, Orla Tuohy
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 110(50)
The association between lymphopenia and autoimmunity is recognized, but the underlying mechanisms are poorly understood and have not been studied systematically in humans. People with multiple sclerosis treated with the lymphocyte-depleting monoclona
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b70aa7fbb8dead865f38f963a246f7d
https://pubmed.ncbi.nlm.nih.gov/24282306
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8
Increased THEMIS First Exon Usage in CD4+ T-Cells Is Associated with a Genotype that Is Protective against Multiple Sclerosis
Autor: Maria Ban, Harpreet Kaur-Sandhu, Stephen Sawcer, Alasdair Coles, Jessica L. Davies, Sara A. J. Thompson, Joanne L. Jones
Publikováno v: PLoS ONE
PLoS ONE, Vol 11, Iss 7, p e0158327 (2016)
Multiple sclerosis is an autoimmune disease of the central nervous system. Genome wide association studies have identified over 100 common variants associated with multiple sclerosis, the majority of which implicate immunologically relevant genes, pa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbff187bfcec659c0112b62cf677161e
https://doi.org/10.1371/journal.pone.0158327
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