Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jessica L Binder"'
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0230026 (2020)
Pathological accumulation of microtubule associated protein tau in neurons is a major neuropathological hallmark of Alzheimer's disease (AD) and related tauopathies. Several attempts have been made to promote clearance of pathological tau (p-Tau) fro
Externí odkaz:
https://doaj.org/article/7cd30d21b32447aea19b7e30d252aaf8
Autor:
John Erol Evangelista, Daniel J. B. Clarke, Zhuorui Xie, Giacomo B. Marino, Vivian Utti, Sherry L. Jenkins, Taha Mohseni Ahooyi, Cristian G. Bologa, Jeremy J. Yang, Jessica L. Binder, Praveen Kumar, Christophe G. Lambert, Jeffrey S. Grethe, Eric Wenger, Deanne Taylor, Tudor I. Oprea, Bernard de Bono, Avi Ma’ayan
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-14 (2023)
Abstract Background Birth defects are functional and structural abnormalities that impact about 1 in 33 births in the United States. They have been attributed to genetic and other factors such as drugs, cosmetics, food, and environmental pollutants d
Externí odkaz:
https://doaj.org/article/3b529ae9cc3f41ad82da2371efbd1a29
Autor:
John Erol Evangelista, Daniel J. B. Clarke, Zhuorui Xie, Giacomo B. Marino, Vivian Utti, Taha M. Ahooyi, Sherry L. Jenkins, Deanne Taylor, Cristian G. Bologa, Jeremy J. Yang, Jessica L. Binder, Praveen Kumar, Christophe G. Lambert, Jeffrey S. Grethe, Eric Wenger, Tudor I. Oprea, Bernard de Bono, Avi Ma’ayan
Birth defects are functional and structural abnormalities that impact 1 in 33 births in the United States. Birth defects have been attributed to genetic as well as other factors, but for most birth defects there are no known causes. Small molecule dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36fcaf7345434da03c63ea9da88c526f
https://doi.org/10.1101/2022.09.15.508198
https://doi.org/10.1101/2022.09.15.508198
Autor:
Jielin Xu, Chengsheng Mao, Yuan Hou, Yuan Luo, Jessica L. Binder, Yadi Zhou, Lynn M. Bekris, Jiyoung Shin, Ming Hu, Fei Wang, Charis Eng, Tudor I. Oprea, Margaret E. Flanagan, Andrew A. Pieper, Jeffrey Cummings, James B. Leverenz, Feixiong Cheng
Publikováno v:
Cell reports. 41(9)
Translating human genetic findings (genome-wide association studies [GWAS]) to pathobiology and therapeutic discovery remains a major challenge for Alzheimer's disease (AD). We present a network topology-based deep learning framework to identify dise
Autor:
Eryk Kropiwnicki, Jessica L. Binder, Jeremy J. Yang, Jayme Holmes, Alexander Lachmann, Daniel J. B. Clarke, Timothy Sheils, Keith J. Kelleher, Vincent T. Metzger, Cristian G. Bologa, Tudor I. Oprea, Avi Ma'ayan
Publikováno v:
Current Protocols. 2
The Illuminating the Druggable Genome (IDG) consortium is a National Institutes of Health (NIH) Common Fund program designed to enhance our knowledge of under-studied proteins, more specifically, proteins unannotated within the three most commonly dr
Autor:
J. Berendzen, A. O. Stevens, Nikolay V. Dokholyan, Jessica L. Binder, Y. He, J. Wang, T. I. Oprea
We investigate the use of confidence scores to predict the accuracy of a given AlphaFold model for drug discovery. Predicted accuracy is improved by eliminating confidence scores below 80, due to effects of disorder. 95% of models corresponding to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f3e8521fc5f3150e83108158f11c6a6
https://doi.org/10.1101/2021.11.04.467322
https://doi.org/10.1101/2021.11.04.467322
Autor:
Jessica L. Binder, Joel Berendzen, Amy O. Stevens, Yi He, Jian Wang, Nikolay V. Dokholyan, Tudor I. Oprea
Publikováno v:
Current opinion in structural biology. 74
We investigate the use of confidence scores to evaluate the accuracy of a given AlphaFold (AF2) protein model for drug discovery. Prediction of accuracy is improved by not considering confidence scores below 80 due to the effects of disorder. On a se
Autor:
Brian Foote, Christopher Gessner, Jessica L. Binder, Kyle Stirling, Joel L Duerksen, Daniel Biber, Ying Ding, Jeremy J. Yang, Murat Ozturk, Robin McEntire, David J. Wild
BackgroundLINCS, “Library of Integrated Network-based Cellular Signatures”, and IDG, “Illuminating the Druggable Genome”, are both NIH projects and consortia that have generated rich datasets for the study of the molecular basis of human heal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cdff7ed12d540016ffddf9401d7fa7f
https://doi.org/10.1101/2020.12.30.424881
https://doi.org/10.1101/2020.12.30.424881
Autor:
Yuriy Bandera, Mary K. Burdette, Eric Zhang, Jessica L. Binder, Isabell Foulger, Jason P. Weick, Stephen H. Foulger, Haley W. Jones
Publikováno v:
Optical Materials Express. 11:1742
Core/shell nanoparticles composed of a silica core over which a propargyl methacrylate (PMA) shell was polymerized around were synthesized. To employ the shell coating, the surface of the silica nanoparticles (SiNPs) was modified with an alkene-termi
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 3, p e0230026 (2020)
PLoS ONE, Vol 15, Iss 3, p e0230026 (2020)
Pathological accumulation of microtubule associated protein tau in neurons is a major neuropathological hallmark of Alzheimer's disease (AD) and related tauopathies. Several attempts have been made to promote clearance of pathological tau (p-Tau) fro