Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jessica L, Ochoa"'
Publikováno v:
Analytical Chemistry. 94:16095-16102
The advent of benchtop nuclear magnetic resonance (NMR) instrumentation has paved the way for the use of this technology away from traditional NMR facility settings. Still, a wider adoption of benchtop NMR systems for routine identification testing h
Autor:
Elinor Hortle, David I. Roper, Warwick J. Britton, Richard J. Payne, Gregory M. Cook, Wendy Tran, Paige M. E. Hawkins, Alexander Stoye, Christopher G. Dowson, Rebecca E Audette, Thomas Balle, Jessica L. Ochoa, Gayathri Nagalingam, Daniel J Ford, Ali Saad Kusay, Venugopal Pujari, Roger G. Linington, Chen-Yi Cheung, Dean C. Crick, Eric J. Rubin, Stefan H. Oehlers, Susan A. Charman
Publikováno v:
Journal of Medicinal Chemistry. 64:17326-17345
Herein, we report the design and synthesis of inhibitors of Mycobacterium tuberculosis (Mtb) phospho-MurNAc-pentapeptide translocase I (MurX), the first membrane-associated step of peptidoglycan synthesis, leveraging the privileged structure of the s
Autor:
Wendy, Tran, Ali S, Kusay, Paige M E, Hawkins, Chen-Yi, Cheung, Gayathri, Nagalingam, Venugopal, Pujari, Daniel J, Ford, Alexander, Stoye, Jessica L, Ochoa, Rebecca E, Audette, Elinor, Hortle, Stefan H, Oehlers, Susan A, Charman, Roger G, Linington, Eric J, Rubin, Christopher G, Dowson, David I, Roper, Dean C, Crick, Thomas, Balle, Gregory M, Cook, Warwick J, Britton, Richard J, Payne
Publikováno v:
Journal of medicinal chemistry. 64(23)
Herein, we report the design and synthesis of inhibitors of
Autor:
Roger G. Linington, Richard J. Payne, Jessica L. Ochoa, Warwick J. Britton, Andrew M. Giltrap, Gayathri Nagalingam, Luke J. Dowman
Publikováno v:
Organic Letters. 18:2788-2791
The first total synthesis of the cyclic depsipeptide natural product teixobactin is described. Synthesis was achieved by solid-phase peptide synthesis, incorporating the unusual l-allo-enduracididine as a suitably protected synthetic cassette and emp
The glycinocins are a class of calcium-dependent, acidic cyclolipopeptide antibiotics that are structurally related to the clinically approved antibiotic daptomycin. In this article, we describe the synthesis of a small library of glycinocin analogue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7722adf2d6f82b352ce653c790b09f82
https://hdl.handle.net/2123/22442
https://hdl.handle.net/2123/22442
Autor:
Jennifer S. Doherty, Byoung-Mo Koo, Jessica L. Ochoa, Roger G. Linington, Carol A. Gross, Kerwyn Casey Huang, Laura M. Sanchez, Manohary Rajendram
Publikováno v:
ACS infectious diseases, vol 4, iss 1
The recent explosion of research on the microbiota has highlighted the important interplay between commensal microorganisms and the health of their cognate hosts. Metabolites isolated from commensal bacteria have been demonstrated to possess a range
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d3f4e6862bcd51c5d04c6f2e06a68b6
https://escholarship.org/uc/item/67x0j0s8
https://escholarship.org/uc/item/67x0j0s8
Publikováno v:
J Nat Prod
Phenotype-guided natural products discovery is emerging as a useful new discovery tool that addresses challenges in early, unbiased natural product biological annotation. These high-content approaches yield screening results that report directly on t
The glycinocins are a class of calcium-dependent, acidic cyclolipopeptide antibiotics structurally related to the clinically approved daptomycin. Herein, we describe a divergent total synthesis of glycinocins A–C, which differ in the structure of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d99d83dfd7f598313b0851e8b4f9cf3a
https://pubs.acs.org/doi/10.1021/acs.joc.7b01959
https://pubs.acs.org/doi/10.1021/acs.joc.7b01959