Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jessica L, Makofske"'
Autor:
Artyom A. Alekseyenko, Barry M. Zee, Zuzer Dhoondia, Hyuckjoon Kang, Jessica L. Makofske, Mitzi I. Kuroda
Publikováno v:
bioRxiv
Aberrant transcriptional programming and chromatin dysregulation are common to most cancers. Whether by deranged cell signaling or environmental insult, the resulting oncogenic phenotype is typically manifested in transcriptional changes characterist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74b0f900e65875892ab84dbea39e7206
https://europepmc.org/articles/PMC10153199/
https://europepmc.org/articles/PMC10153199/
Autor:
Mitzi I. Kuroda, Dominik Ricken, Bruno Di Stefano, Emma V. Watson, Marit A.C. de Kort, Eric C. Wooten, Mohammed Dezfulian, Timothy D. Martin, Konrad Hochedlinger, Kamila Naxerova, Jessica L. Makofske, Stephen J. Elledge
Publikováno v:
Genes & Development. 35:1527-1547
Understanding the genetic control of human embryonic stem cell function is foundational for developmental biology and regenerative medicine. Here we describe an integrated genome-scale loss- and gain-of-function screening approach to identify genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c0e82741139d4878eec0d417d932b2
https://doi.org/10.1101/gad.349048.121
https://doi.org/10.1101/gad.349048.121
Autor:
David J. Meyers, Beth E. Zucconi, Philip A. Cole, Mingxuan Wu, Mitzi I. Kuroda, Jessica L. Makofske, Yousang Hwang
Publikováno v:
Biochemistry. 58:2133-2143
p300 and CBP are highly related histone acetyltransferase (HAT) enzymes that regulate gene expression, and their dysregulation has been linked to cancer and other diseases. p300/CBP is composed of a number of domains including a HAT domain which is i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb6eca6f6a65de0ac0bb5cff2ca0dbc1
https://doi.org/10.1021/acs.biochem.9b00160
https://doi.org/10.1021/acs.biochem.9b00160
Autor:
Janna Minehart, Scott A. Armstrong, S. Haihua Chu, Evelyn J. Song, Andrei V. Krivtsov, Chloe N. Matovina, Richard Koche, Kenneth N. Ross, Elizabeth S. Frank, André Nussenzweig, Zhaohui Feng, Jessica L. Makofske, Jonathan Chabon, Haiming Xu
Publikováno v:
Blood Advances. 2:2478-2490
Infant B-cell acute lymphoblastic leukemias (B-ALLs) that harbor MLL-AF4 rearrangements are associated with a poor prognosis. One important obstacle to progress for this patient population is the lack of immunocompetent models that faithfully recapit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0354765d51f996efa50a9ccb4050ff5
https://doi.org/10.1182/bloodadvances.2018021592
https://doi.org/10.1182/bloodadvances.2018021592
Autor:
S Haihua, Chu, Evelyn J, Song, Jonathan R, Chabon, Janna, Minehart, Chloe N, Matovina, Jessica L, Makofske, Elizabeth S, Frank, Kenneth, Ross, Richard P, Koche, Zhaohui, Feng, Haiming, Xu, Andrei, Krivtsov, Andre, Nussenzweig, Scott A, Armstrong
Publikováno v:
Blood advances. 2(19)
Mll-Af4 and mutant N-Ras cooperate to generate an aggressive B-acute lymphoblastic leukemia murine model, recapitulating human disease.Combination MEK and ATR inhibitor treatment of Mll-Af4/N-Ras leukemia induces synergistic antileukemic effects in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8c2544b87cb03c7910c2cd57ffafaafe
https://pubmed.ncbi.nlm.nih.gov/30266823
https://pubmed.ncbi.nlm.nih.gov/30266823