Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jessica L, Keenan"'
Autor:
David Bray, Heather Hook, Rose Zhao, Jessica L. Keenan, Ashley Penvose, Yemi Osayame, Nima Mohaghegh, Xiaoting Chen, Sreeja Parameswaran, Leah C. Kottyan, Matthew T. Weirauch, Trevor Siggers
Publikováno v:
Cell Genomics, Vol 2, Iss 2, Pp 100098- (2022)
Summary: Non-coding DNA variants (NCVs) impact gene expression by altering binding sites for regulatory complexes. New high-throughput methods are needed to characterize the impact of NCVs on regulatory complexes. We developed CASCADE (Customizable A
Externí odkaz:
https://doaj.org/article/24f2f3e6b99f4f76a712569026ef3d1a
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The type II nuclear receptors (NRs) and the retinoid X receptor (RXR) form heterodimeric transcription factors to regulate development, metabolism, and inflammation. Here the authors employ protein-binding microarrays to comprehensively analyze the D
Externí odkaz:
https://doaj.org/article/79e323cec1f2436e87f4111b7b42c180
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2366
Nuclear factor-kappa B (NF-κB) transcription factors coordinate gene expression in response to a broad array of cellular signals. In vertebrates, there are five NF-κB proteins (c-Rel, RelA/p65, RelB, p50, and p52) that can form various dimeric comb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dac93891a016e2e690aa5ccc5ed2ce68
https://pubmed.ncbi.nlm.nih.gov/34236632
https://pubmed.ncbi.nlm.nih.gov/34236632
Publikováno v:
Methods in Molecular Biology ISBN: 9781071616680
Nuclear factor-kappa B (NF-κB) transcription factors coordinate gene expression in response to a broad array of cellular signals. In vertebrates, there are five NF-κB proteins (c-Rel, RelA/p65, RelB, p50, and p52) that can form various dimeric comb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9919f70a3cd1c8b6897286dff9c943b7
https://doi.org/10.1007/978-1-0716-1669-7_4
https://doi.org/10.1007/978-1-0716-1669-7_4
Autor:
Osayame Y, Ashley Penvose, Rose W. Zhao, Hook H, Nima Mohaghegh, David Bray, Jessica L. Keenan, Trevor Siggers
Determining how DNA variants affect the binding of regulatory complexes to cis-regulatory elements (CREs) and non-coding single-nucleotide polymorphisms (ncSNPs) is a challenge in genomics. To address this challenge, we have developed CASCADE (Compre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a33315902cf95a64dadba86e67c04d
https://doi.org/10.1101/2020.04.21.053710
https://doi.org/10.1101/2020.04.21.053710
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The type II nuclear receptors (NRs) function as heterodimeric transcription factors with the retinoid X receptor (RXR) to regulate diverse biological processes in response to endogenous ligands and therapeutic drugs. DNA-binding specificity has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fecb5073f33097e1a57a2babf7436b7c
http://europepmc.org/articles/PMC6555819
http://europepmc.org/articles/PMC6555819
Autor:
Daniel T. Zuch, John D. Hogan, Jonas Ibn-Salem, Miguel A. Andrade-Navarro, Bernd Timmermann, Lingqi Luo, Cynthia A. Bradham, Daphne Schatzberg, Jessica L. Keenan, Naoki Irie, Albert J. Poustka, José Horacio Grau, Dakota Y. Hawkins, Amanda B. Core, Carolyn Blumberg, Emily Speranza, Arjun Lamba, Michael L. Piacentino
Publikováno v:
bioRxiv
Developmental Biology
Developmental Biology
Embryonic development is arguably the most complex process an organism undergoes during its lifetime, and understanding this complexity is best approached with a systems-level perspective. The sea urchin has become a highly valuable model organism fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ee7b9ba73ded6efba4e3292e8c47f49
Autor:
Trevor Siggers, Nima Mohaghegh, Jessica L. Keenan, Kellen K Andrilenas, David Bray, Ashley Penvose, Vijendra Ramlall
Determining the biophysical principles that shape transcription factor (TF) binding in a cell-specific manner is key to quantitative models of gene expression. High-throughput (HT) in vitro methods measuring protein-DNA binding are invaluable for rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4214cb2b6ae01b73009b7bc4edaff43a
Autor:
Trevor Siggers, Jessica L. Keenan, David Bray, Ashley Penvose, Nima Mohaghegh, Kellen K Andrilenas, Vijendra Ramlall
Publikováno v:
Nucleic Acids Research
High-throughput (HT) in vitro methods for measuring protein-DNA binding have become invaluable for characterizing transcription factor (TF) complexes and modeling gene regulation. However, current methods do not utilize endogenous proteins and, there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07c7c574610467fe881cc7bc05d6875
https://doi.org/10.1093/nar/gkz020
https://doi.org/10.1093/nar/gkz020
Autor:
James Chaves, Jia Yu, Daniel T. Zuch, Hajerah Hameeduddin, Evan S. Bardot, Arlene Reyna, John D. Hogan, Oliver Chung, Jasmin Coulombe-Huntington, Lingqi Luo, Patrick Ferrell, Sviatlana Rose, Todd A. Blute, Finnegan B. Hewitt, Albert J. Poustka, Ekaterina Oleinik, Amanda B. Core, Jonas Ibn-Salem, Christy Li, Vijeta Patel, Michael L. Piacentino, Janani Ramachandran, Emily Speranza, Cynthia A. Bradham, David Lee, Julie Fishman, Jessica L. Keenan
Publikováno v:
Development (Cambridge, England). 143(4)
The sea urchin larval skeleton offers a simple model for developmental pattern formation. The calcium carbonate skeleton is secreted by primary mesenchyme cells (PMCs) in response to largely unknown patterning cues expressed by the ectoderm. To disco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6307aa7808cba2c585eedccce263684
https://pubmed.ncbi.nlm.nih.gov/26755701
https://pubmed.ncbi.nlm.nih.gov/26755701