Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jessica Kho"'
Autor:
Jessica Kho, Suhyeon Kwon, Heath Ecroyd, P Chi Pham, Huixin Wang, Shelli R McAlpine, Alana Y Huang, W Alexander Donald, Joel P Rivers
Publikováno v:
ACS Med Chem Lett
[Image: see text] We report the first small molecule peptides based on the N-terminal sequence of heat shock protein 27 (Hsp27, gene HSPB1) that demonstrates chaperone-like activity. The peptide, comprising the SWDPF sequence located at Hsp27’s ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09a41c52f679fa3069245c265df54d1
https://doi.org/10.1021/acsmedchemlett.0c00609
https://doi.org/10.1021/acsmedchemlett.0c00609
Autor:
Shelli R. McAlpine, Samantha S. Zaiter, Lok K. O. Lam, Marwa N. Rahimi, David A. Neale, Gabriel D. Moldovan, Suhyeon Kwon, Jessica Kho, Michael Leong, Gillian Thornton, Jenane Konesan, Vickie Chan, Laura K. Buckton, Michael F. Lawler, Aldwin Guo
Publikováno v:
ACS Medicinal Chemistry Letters
Herein, we describe the synthesis and structure–activity relationships of cyclic peptides designed to target heat shock protein 90 (Hsp90). Generating 19 compounds and evaluating their binding affinity reveals that increasing electrostatic interact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d95234de22b1366007e162e32f61d2
https://doi.org/10.1021/acsmedchemlett.7b00310
https://doi.org/10.1021/acsmedchemlett.7b00310
Autor:
Nicole L. Richardson, Sheena Y. Nguyen, Samantha S. Zaiter, Jessica Kho, Yen Chin Koay, Laura K. Buckton, Daniel H. Tran, Ka Wai Lee, Shelli R. McAlpine
Publikováno v:
ChemMedChem. 11(8)
Macrocycles have several advantages over small-molecule drugs when it comes to addressing specific protein-protein interactions as therapeutic targets. Herein we report the synthesis of seven new cyclic peptide molecules and their biological activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c08933b26bfd5d2deeaad12f4fd0931f
https://pubmed.ncbi.nlm.nih.gov/26805515
https://pubmed.ncbi.nlm.nih.gov/26805515
Publikováno v:
Science. 6/11/2021, Vol. 372 Issue 6547, p1230-1234. 4p. 1 Color Photograph.
Autor:
Koay, Yen Chin, Richardson, Nicole L., Zaiter, Samantha S., Kho, Jessica, Nguyen, Sheena Y., Tran, Daniel H., Lee, Ka Wai, Buckton, Laura K., McAlpine, Shelli R.
Publikováno v:
ChemMedChem; Apr2016, Vol. 11 Issue 8, p881-892, 12p