Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Jessica K. Simmons"'
Autor:
Wachiraphan Supsavhad, Bardes B. Hassan, Jessica K. Simmons, Wessel P. Dirksen, Said M. Elshafae, Nicole A. Kohart, Aylin A. Demirer, Thomas J. Rosol
Publikováno v:
Veterinary Sciences, Vol 8, Iss 8, p 153 (2021)
Human Dickkopf-1 (Dkk-1) upregulates a noncanonical Wnt/JNK pathway, resulting in osteoclast stimulation, cell proliferation, and epithelial-to-mesenchymal transition (EMT) of cancer cells. Ace-1-Dkk-1, a canine prostate cancer (PCa) cell line overex
Externí odkaz:
https://doaj.org/article/9d6d353af4674b7582e8ede2f60af26e
Publikováno v:
Veterinary Sciences, Vol 1, Iss 1, Pp 16-39 (2014)
Prostate cancer bone metastases are associated with a poor prognosis and are considered incurable. Insight into the formation and growth of prostate cancer bone metastasis is required for development of new imaging and therapeutic strategies to comba
Externí odkaz:
https://doaj.org/article/25734d4dc2df408e80486cbb698f4513
Autor:
Robert P. Lyon, Peter D. Senter, Erica E. McKinney, Jessica K. Simmons, Michelle L. Ulrich, Ivan J. Stone, Martha E. Anderson, Jamie B. Miyamoto, Nicole M. Okeley, Svetlana O. Doronina, Joshua H. Hunter, Scott C. Jeffrey, Joseph Z. Hamilton, Patrick J. Burke
SEC overlays of ADCs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a05ef04826825bab786355b4cfdf781
https://doi.org/10.1158/1535-7163.22508659
https://doi.org/10.1158/1535-7163.22508659
Autor:
Scott C. Jeffrey, Peter D. Senter, Maureen C. Ryan, Lauren M. Farr, Steven Jin, Katie M. Snead, Margo C. Zaval, David J. Ortiz, Esther S. Trueblood, Jessica K. Simmons, Francisco Zapata, Kim K. Emmerton, Nicole M. Okeley, Julia H. Cochran, David W. Meyer, Uland Y. Lau, Lauren B. Bou, Ryan D. Lyski
We have developed a highly active and well-tolerated camptothecin (CPT) drug-linker designed for antibody-mediated drug delivery in which the lead molecule consists of a 7-aminomethyl-10,11-methylenedioxy CPT (CPT1) derivative payload attached to a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ddd96a490a7c4a1c623e44498733d0
https://doi.org/10.1158/1535-7163.c.6543066.v1
https://doi.org/10.1158/1535-7163.c.6543066.v1
Autor:
Peter D. Senter, Robert P. Lyon, Weiping Zeng, Margo C. Zaval, Abbie Wong, Andrew B. Waight, Michelle L. Ulrich, Jessica K. Simmons, Paul G. Pittman, Jay C. Nix, Jason Neale, David W. Meyer, Luke V. Loftus, Fu Li, Steven Jin, Julia H. Cochran, Martha E. Anderson, Kathleen C. Olivas, Christopher S. Neumann
Detailed methods for ADC analytics and chemical sysnthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::916122efb9c585694b4a5165b3263a57
https://doi.org/10.1158/1535-7163.22505815
https://doi.org/10.1158/1535-7163.22505815
Autor:
Peter D. Senter, Robert P. Lyon, Weiping Zeng, Margo C. Zaval, Abbie Wong, Andrew B. Waight, Michelle L. Ulrich, Jessica K. Simmons, Paul G. Pittman, Jay C. Nix, Jason Neale, David W. Meyer, Luke V. Loftus, Fu Li, Steven Jin, Julia H. Cochran, Martha E. Anderson, Kathleen C. Olivas, Christopher S. Neumann
Antibody–drug conjugates (ADCs) are a therapeutic modality that enables the targeted delivery of cytotoxic drugs to cancer cells. Identification of active payloads with unique mechanisms of action is a key aim of research efforts in the field. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::573a206071ce06934ff2470390402a2e
https://doi.org/10.1158/1535-7163.c.6538195.v1
https://doi.org/10.1158/1535-7163.c.6538195.v1
Autor:
Svetlana O. Doronina, Peter D. Senter, Robert P. Lyon, Jessica K. Simmons, Cindy Balasubramanian, Nicole Stevens, Kim K. Emmerton, Marsha L. Mason, Jamie B. Miyamoto, Jamie A. Mitchell, Andrew B. Waight, Tim D. Bovee, Philip N. Moquist
Supplementary Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df524670b0ec7bba662eb1af95d3ac8
https://doi.org/10.1158/1535-7163.22521751
https://doi.org/10.1158/1535-7163.22521751
Autor:
Scott C. Jeffrey, Peter D. Senter, Maureen C. Ryan, Lauren M. Farr, Steven Jin, Katie M. Snead, Margo C. Zaval, David J. Ortiz, Esther S. Trueblood, Jessica K. Simmons, Francisco Zapata, Kim K. Emmerton, Nicole M. Okeley, Julia H. Cochran, David W. Meyer, Uland Y. Lau, Lauren B. Bou, Ryan D. Lyski
Table S1, Table S2, Table S3, Figure S1, Figure S2, Figure S3, Figure S4, Figure S5, Figure S6, Figure S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e410c38e426960942627197b18516708
https://doi.org/10.1158/1535-7163.22521576.v1
https://doi.org/10.1158/1535-7163.22521576.v1
Autor:
Esther S. Trueblood, Steven Jin, Uland Y. Lau, Francisco Zapata, Lauren Bou, Lauren Farr, David Ortiz, Jessica K. Simmons, Kim K. Emmerton, Ryan Lyski, Julia H. Cochran, Scott C. Jeffrey, Maureen Ryan, Margo Zaval, Nicole M. Okeley, Peter D. Senter, Katie Snead, David W. Meyer
Publikováno v:
Molecular Cancer Therapeutics. 20:329-339
We have developed a highly active and well-tolerated camptothecin (CPT) drug-linker designed for antibody-mediated drug delivery in which the lead molecule consists of a 7-aminomethyl-10,11-methylenedioxy CPT (CPT1) derivative payload attached to a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b216df9ed51afa64da2a7b5ad17ed50
https://doi.org/10.1158/1535-7163.mct-20-0526
https://doi.org/10.1158/1535-7163.mct-20-0526
Autor:
Nicole A. Kohart, Jessica K. Simmons, Wessel P. Dirksen, Bardes B. Hassan, Wachiraphan Supsavhad, Aylin A. Demirer, Said M. Elshafae, Thomas J. Rosol
Publikováno v:
Veterinary Sciences
Volume 8
Issue 8
Veterinary Sciences, Vol 8, Iss 153, p 153 (2021)
Volume 8
Issue 8
Veterinary Sciences, Vol 8, Iss 153, p 153 (2021)
Human Dickkopf-1 (Dkk-1) upregulates a noncanonical Wnt/JNK pathway, resulting in osteoclast stimulation, cell proliferation, and epithelial-to-mesenchymal transition (EMT) of cancer cells. Ace-1-Dkk-1, a canine prostate cancer (PCa) cell line overex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d44bb14ca0443419c8010f415b89c0
http://europepmc.org/articles/PMC8402794
http://europepmc.org/articles/PMC8402794