HIV Antibody Fc N-Linked Glycosylation Is Associated with Viral Rebound

Autor: Ole Schmeltz Søgaard, Saheli Sadanand, Zelda Euler, Dan H. Barouch, Galit Alter, Douglas A. Lauffenburger, Caitlyn Linde, Jessica K. Sassic, Thomas A Rasmussen, Stephanie Fischinger, Martin Tolstrup, Madeleine F. Jennewein, Todd J. Suscovich, Giuseppe Lofano, Richelle C. Charles, Eileen P. Scully, Selena Vigano, Lu Zheng, Rasmus Offersen, Boris Julg, Lars Østergaard, Kathryn E. Stephenson, Mathias Lichterfeld, Marcus Altfeld, Erik S. Rosenberg, Dario Garcia-Dominguez, Wen-Han Yu, Todd M. Allen

Publikováno v: Offersen, R, Yu, W H, Scully, E P, Julg, B, Euler, Z, Sadanand, S, Garcia-Dominguez, D, Zheng, L, Rasmussen, T A, Jennewein, M F, Linde, C, Sassic, J, Lofano, G, Vigano, S, Stephenson, K E, Fischinger, S, Suscovich, T J, Lichterfeld, M, Lauffenburger, D, Rosenberg, E S, Allen, T, Altfeld, M, Charles, R C, Østergaard, L, Tolstrup, M, Barouch, D H, Søgaard, O S & Alter, G 2020, ' HIV Antibody Fc N-Linked Glycosylation Is Associated with Viral Rebound ', Cell Reports, vol. 33, no. 11, 108502 . https://doi.org/10.1016/j.celrep.2020.108502
Cell Reports, Vol 33, Iss 11, Pp 108502-(2020)

Summary: Changes in antibody glycosylation are linked to inflammation across several diseases. Alterations in bulk antibody galactosylation can predict rheumatic flares, act as a sensor for immune activation, predict gastric cancer relapse, track wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d0578ca9f83e1851a7b68b591e3801
https://pure.au.dk/portal/da/publications/hiv-antibody-fc-nlinked-glycosylation-is-associated-with-viral-rebound(bd1a4a57-9284-4d9d-91dd-a84f39e18987).html

Route of immunization defines multiple mechanisms of vaccine-mediated protection against SIV

Autor: Sean O’Keefe, Derrick Goodman, Nickita Mehta, Douglas A. Lauffenburger, Thomas Broge, Eric P. Brown, Jessica K. Sassic, Caitlyn Linde, Srivamshi Pittala, Magdalena Sips, Mario Roederer, Harini Natarajan, Todd J. Suscovich, Shu Lin, Georgia D. Tomaras, Joshua A. Weiner, Todd Bradley, Jishnu Das, Barton F. Haynes, Galit Alter, Margaret E. Ackerman, Chris Bailey-Kellogg

Publikováno v: Nature Medicine. 24:1590-1598

Antibodies are the primary correlate of protection for most licensed vaccines; however, their mechanisms of protection may vary, ranging from physical blockade to clearance via the recruitment of innate immunity. Here, we uncover striking functional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c48e0b0ad746c868cd73e659b81ea3b
https://doi.org/10.1038/s41591-018-0161-0

Bimodal regulation of an Elk subfamily K+ channel by phosphatidylinositol 4,5-bisphosphate

Autor: Damian B. van Rossum, Timothy Jegla, Kendra Pivaroff-Ward, Xiaofan Li, Jessica K. Sassic, Andriy Anishkin, David Gallegos, Hansi Liu, Sree V. Chintapalli

Publikováno v: The Journal of General Physiology

PIP2 mediates the bimodal regulation of the EAG family K+ channel ELK1 to produce an overall inhibitory effect.
Phosphatidylinositol 4,5-bisphosphate (PIP2) regulates Shaker K+ channels and voltage-gated Ca2+ channels in a bimodal fashion by inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0f33197adeaea9dbc00fac6002f2cb2
https://pubmed.ncbi.nlm.nih.gov/26503718

Evolutionary Origins of the Shaker Family of Voltage-Gated Potassium Channels

Autor: Fortunay H. Diatta, Xiaofan Li, Sarah A. Rhodes, Timothy Jegla, Jessica K. Sassic, Mark Q. Martindale, Liana Trigg, Hansi Liu, David Simmons

Publikováno v: Biophysical Journal. 108(2)

The Shaker family of voltage-gated K+ channels in bilaterians consists of four closely related gene subfamilies (Shaker, Shab, Shaw and Shal) that regulate neuronal excitability in diverse ways. We examined the evolutionary origins of the gene family

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f68b600b49d8c69e53bb09f85ab3c489