Výsledky vyhledávání - "Jessica K. Nelson"

Akademický článek

Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12

Autor: Omar M. Khan, Jorge Almagro, Jessica K. Nelson, Stuart Horswell, Vesela Encheva, Kripa S. Keyan, Bruce E. Clurman, Ambrosius P. Snijders, Axel Behrens

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

The tumor suppressor FBW7 is a substrate adaptor for the E3 ubiquitin ligase complex SKP1-CUL1-F-box (SCF) and itself a target for ubiquitylation. Here, the authors show that TRIP12 mediates branched K11-linked ubiquitylation of FBW7, to regulate its

Externí odkaz: https://doaj.org/article/6e27448b8929476da30da600acc41eb2

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Akademický článek

The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation

Autor: Vincenzo Sorrentino, Jessica K. Nelson, Elena Maspero, André R.A. Marques, Lilith Scheer, Simona Polo, Noam Zelcer

Publikováno v: Journal of Lipid Research, Vol 54, Iss 8, Pp 2174-2184 (2013)

Low density lipoprotein (LDL) cholesterol is taken up into cells via clathrin-mediated endocytosis of the LDL receptor (LDLR). Following dissociation of the LDLR-LDL complex, LDL is directed to lysosomes whereas the LDLR recycles to the plasma membra

Externí odkaz: https://doaj.org/article/695bff5da0664a00b1b31b5753bab0ed

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Akademický článek

Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene.

Autor: Emma C L Cook, Jessica K Nelson, Vincenzo Sorrentino, Duco Koenis, Martina Moeton, Saskia Scheij, Roelof Ottenhoff, Boris Bleijlevens, Anke Loregger, Noam Zelcer

Publikováno v: PLoS ONE, Vol 12, Iss 2, p e0172721 (2017)

Cellular cholesterol metabolism is subject to tight regulation to maintain adequate levels of this central lipid molecule. Herein, the sterol-responsive Liver X Receptors (LXRs) play an important role owing to their ability to reduce cellular cholest

Externí odkaz: https://doaj.org/article/ace271f92020402192c273dfc41da462

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Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12

Autor: Kripa S. Keyan, Jorge Almagro, Bruce E. Clurman, Ambrosius P. Snijders, Stuart Horswell, Vesela Encheva, Jessica K. Nelson, Axel Behrens, Omar M. Khan

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications

The tumour suppressor FBW7 is a substrate adaptor for the E3 ubiquitin ligase complex SKP1-CUL1-F-box (SCF), that targets several oncoproteins for proteasomal degradation. FBW7 is widely mutated and FBW7 protein levels are commonly downregulated in c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52317b9d43255e960ff3720013d3922f
https://doaj.org/article/6e27448b8929476da30da600acc41eb2

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USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer

Autor: Jessica K. Nelson, May Zaw Thin, Theodore Evan, Steven Howell, Mary Wu, Bruna Almeida, Nathalie Legrave, Duco S. Koenis, Gabriela Koifman, Yoichiro Sugimoto, Miriam Llorian Sopena, James MacRae, Emma Nye, Michael Howell, Ambrosius P. Snijders, Andreas Prachalias, Yoh Zen, Debashis Sarker, Axel Behrens

Publikováno v: Nature communications. 13(1)

Deubiquitylating enzymes (DUBs) play an essential role in targeted protein degradation and represent an emerging therapeutic paradigm in cancer. However, their therapeutic potential in pancreatic ductal adenocarcinoma (PDAC) has not been explored. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::854e2c25058cbc76694ffc7ae82331fc
https://pubmed.ncbi.nlm.nih.gov/35440539

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Regulation of intestinal LDLR by the LXR-IDOL axis

Autor: Jessica K. Nelson, Nienke M. van Loon, Noam Zelcer, Martina Moeton, Suzanne A.E. van Wouw, Roelof Ottenhoff, Saskia Scheij, Jenina Kingma

Publikováno v: Atherosclerosis, 315, 1-9. Elsevier Ireland Ltd

Background and aims Cholesterol metabolism is tightly regulated by transcriptional and post-transcriptional mechanisms. Accordingly, dysregulation of cholesterol metabolism is a major risk factor for the development of coronary artery disease and ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aadca31bfc399e7a7a2573f7b82e1a09
https://pure.amc.nl/en/publications/regulation-of-intestinal-ldlr-by-the-lxridol-axis(6a64ee1d-17dd-474a-a545-fbf6e6d967c8).html

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LUBAC determines chemotherapy resistance in squamous cell lung cancer

Autor: Ambrosius P. Snijders, Atanu Chakraborty, Vesela Encheva, Alessandro Annibaldi, Mathias Rosenfeldt, Paula Moreno, Marco A. Calzado, Rocio Sancho, Jessica K. Nelson, Axel Behrens, Richard Mitter, E. Josue Ruiz, Markus E. Diefenbacher, Gianmaria Liccardi, Pascal Meier, Fabio Pucci

Publikováno v: The Journal of Experimental Medicine
Ruiz, E J, Diefenbacher, M E, Nelson, J K, Sancho, R, Pucci, F, Chakraborty, A, Moreno, P, Annibaldi, A, Liccardi, G, Encheva, V, Mitter, R, Rosenfeldt, M, Snijders, A P, Meier, P, Calzado, M A & Behrens, A 2019, ' LUBAC determines chemotherapy resistance in squamous cell lung cancer ', The Journal of experimental medicine, vol. 216, no. 2, pp. 450-465 . https://doi.org/10.1084/jem.20180742

This study identifies a novel therapeutic strategy against cisplatin-resistant lung squamous cell carcinoma (LSCC) using mouse models and patient samples. LSCC chemoresistance depends on LUBAC and high NF-κB activity, mechanisms that can be targeted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::938586481f7b5e9f80a52af1980992d2
https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-227146

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Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake

Autor: Peter L. Hordijk, Igor Kovacevic, Saskia Scheij, Emma C. L. Cook, Noam Zelcer, Jessica K. Nelson, Anke Loregger, Huib Ovaa, Marten A. Hoeksema

Publikováno v: Journal of biological chemistry, 291(9), 4813-4825. American Society for Biochemistry and Molecular Biology Inc.
Journal of Biological Chemistry, 291(9), 4813-4825. American Society for Biochemistry and Molecular Biology Inc.
Nelson, J K, Cook, E C L, Loregger, A, Hoeksema, M A, Scheij, S, Kovacevic, I, Hordijk, P L, Ovaa, H & Zelcer, N 2016, ' Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake ', Journal of Biological Chemistry, vol. 291, no. 9, pp. 4813-4825 . https://doi.org/10.1074/jbc.M115.698688

Cholesterol metabolism is subject to complex transcriptional and nontranscriptional regulation. Herein, the role of ubiquitylation is emerging as an important post-translational modification that regulates cholesterol synthesis and uptake. Similar to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cedf0913ddcfb2603c43cc631340d66d
https://doi.org/10.1074/jbc.m115.698688

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The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL

Autor: Rossella Avagliano Trezza, Claire Heride, Vincenzo Sorrentino, Sylvie Urbé, Jessica K. Nelson, Ben Distel, Noam Zelcer

Publikováno v: Circulation research, 118(3), 410-419. Lippincott Williams and Wilkins

Rationale: The low-density lipoprotein (LDL) receptor (LDLR) is a central determinant of circulating LDL-cholesterol and as such subject to tight regulation. Recent studies and genetic evidence implicate the inducible degrader of the LDLR (IDOL) as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81cf8f8c8a4798afe202e37e36e3e53f
https://doi.org/10.1161/circresaha.115.307298

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