Zobrazeno 1 - 10 of 36 pro vyhledávání: '"Jessica K. Lerch"'
1
Akademický článek
Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease
Autor: Vikram Shettigar, Bo Zhang, Sean C. Little, Hussam E. Salhi, Brian J. Hansen, Ning Li, Jianchao Zhang, Steve R. Roof, Hsiang-Ting Ho, Lucia Brunello, Jessica K. Lerch, Noah Weisleder, Vadim V. Fedorov, Federica Accornero, Jill A. Rafael-Fortney, Sandor Gyorke, Paul M. L. Janssen, Brandon J. Biesiadecki, Mark T. Ziolo, Jonathan P. Davis
Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Heart contraction, which is decreased in disease, is determined by Ca2+binding to troponin C. Here, the authors combine a protein engineering approach with gene therapy to modulate heart contractility in mice with the use of rationally designed Tropo
Externí odkaz: https://doaj.org/article/9828c585327046c3b5306a0cb5e0d215
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2
Akademický článek
The Effect of Glucocorticoid and Glucocorticoid Receptor Interactions on Brain, Spinal Cord, and Glial Cell Plasticity
Autor: Kathryn M. Madalena, Jessica K. Lerch
Publikováno v: Neural Plasticity, Vol 2017 (2017)
Stress, injury, and disease trigger glucocorticoid (GC) elevation. Elevated GCs bind to the ubiquitously expressed glucocorticoid receptor (GR). While GRs are in every cell in the nervous system, the expression level varies, suggesting that diverse c
Externí odkaz: https://doaj.org/article/789ac3d9f10e47ac9ec738b9a1e83f2e
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4
Enhancing membrane repair increases regeneration in a sciatic injury model
Autor: Kevin E. McElhanon, Jessica K. Lerch, Thomas A. Kwiatkowski, Rohan Mital, Noah Weisleder, Aubrey L. Rose, Kathryn M. Madalena, Brian J. Paleo
Publikováno v: PLoS ONE, Vol 15, Iss 4, p e0231194 (2020)
PLoS ONE
Various injuries to the neural tissues can cause irreversible damage to multiple functions of the nervous system ranging from motor control to cognitive function. The limited treatment options available for patients have led to extensive interest in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd5633e4237103f27a8c8bcc3bf8dda
https://doaj.org/article/c29e3ca517324b0ab49c948ce8e8fd76
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5
Akademický článek
Isoform diversity and regulation in peripheral and central neurons revealed through RNA-Seq.
Autor: Jessica K Lerch, Frank Kuo, Dario Motti, Richard Morris, John L Bixby, Vance P Lemmon
Publikováno v: PLoS ONE, Vol 7, Iss 1, p e30417 (2012)
To fully understand cell type identity and function in the nervous system there is a need to understand neuronal gene expression at the level of isoform diversity. Here we applied Next Generation Sequencing of the transcriptome (RNA-Seq) to purified
Externí odkaz: https://doaj.org/article/ccd395b1712a4aac885b8c640c162469
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6
Microglia Promote Increased Pain Behavior through Enhanced Inflammation in the Spinal Cord during Repeated Social Defeat Stress
Autor: Daniel B. McKim, John F. Sheridan, Timothy D. Faw, Michelle L. Humeidan, Jessica K. Lerch, Jonathan P. Godbout, Caroline M. Sawicki, D. Michele Basso, January K. Kim, Kathryn M. Madalena, Michael D. Weber
Publikováno v: The Journal of Neuroscience. 39:1139-1149
Clinical studies indicate that psychosocial stress contributes to adverse chronic pain outcomes in patients, but it is unclear how this is initiated or amplified by stress. Repeated social defeat (RSD) is a mouse model of psychosocial stress that act
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfaad9ebd8eb338395f2a0c21d5240e6
https://doi.org/10.1523/jneurosci.2785-18.2018
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7
Unique Sensory and Motor Behavior in Thy1-GFP-M Mice before and after Spinal Cord Injury
Autor: Tyler T Thaxton, Lesley C. Fisher, Rochelle J. Deibert, Timothy D. Faw, Jessica K. Lerch, D. Michele Basso
Publikováno v: Journal of Neurotrauma. 35:2167-2182
Sensorimotor recovery after spinal cord injury (SCI) is of utmost importance to injured individuals and will rely on improved understanding of SCI pathology and recovery. Novel transgenic mouse lines facilitate discovery, but must be understood to be
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e843a2c909c45b3a298d58f8c230917
https://doi.org/10.1089/neu.2017.5395
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8
Identification of mi RNA s involved in DRG neurite outgrowth and their putative targets
Autor: Jessica K. Lerch, Dario Motti, Matt C. Danzi, Jared H. Gans, Tatiana I. Slepak, John L. Bixby, Vance Lemmon, Frank Kuo
Publikováno v: FEBS Letters. 591:2091-2105
Peripheral neurons regenerate their axons after injury. Transcriptional regulation by microRNAs (miRNAs) is one possible mechanism controlling regeneration. We profiled miRNA expression in mouse dorsal root ganglion (DRG) neurons after a sciatic nerv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ad29f2e3b9f301a504eb4563f8bcf2
https://doi.org/10.1002/1873-3468.12718
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9
E6020, a synthetic TLR4 agonist, accelerates myelin debris clearance, Schwann cell infiltration, and remyelination in the rat spinal cord
Autor: Phillip G. Popovich, Lindsay M. Milich, Jamie S. Church, Dana M. McTigue, Jessica K. Lerch
Publikováno v: Glia. 65:883-899
Oligodendrocyte progenitor cells (OPCs) are present throughout the adult brain and spinal cord and can replace oligodendrocytes lost to injury, aging, or disease. Their differentiation, however, is inhibited by myelin debris, making clearance of this
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::055956f44a0740b570037d733ea6d5d4
https://doi.org/10.1002/glia.23132
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