Zobrazeno 1 - 10 of 17 pro vyhledávání: '"Jessica K. Cinkornpumin"'
1
Akademický článek
Deletion of RBMX RGG/RG motif in Shashi-XLID syndrome leads to aberrant p53 activation and neuronal differentiation defects
Autor: Ting Cai, Jessica K. Cinkornpumin, Zhenbao Yu, Oscar D. Villarreal, William A. Pastor, Stéphane Richard
Publikováno v: Cell Reports, Vol 36, Iss 2, Pp 109337- (2021)
Summary: RNA-binding proteins play important roles in X-linked intellectual disability (XLID). In this study, we investigate the contribution of the XLID-associated RBMX in neuronal differentiation. We show that RBMX-depleted cells exhibit aberrant a
Externí odkaz: https://doaj.org/article/4b8b56a3a07d49d8994914c2ecc0e07b
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3
Mapping Chromatin Accessibility in Human Naïve Pluripotent Stem Cells Using ATAC-Seq
Autor: Jessica K, Cinkornpumin, Ishtiaque, Hossain, William A, Pastor
Publikováno v: Methods in molecular biology (Clifton, N.J.). 2416
Regulatory elements, such as promoters and enhancers, typically show reduced nucleosome occupancy, which is a feature that is commonly referred to as "open chromatin". The distribution of open chromatin sites can provide important clues about the tra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ceea28a931b70a8abdbfe365e638f4f4
https://pubmed.ncbi.nlm.nih.gov/34870838
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4
Akademický článek
A host beetle pheromone regulates development and behavior in the nematode Pristionchus pacificus
Autor: Jessica K Cinkornpumin, Dona R Wisidagama, Veronika Rapoport, James L Go, Christoph Dieterich, Xiaoyue Wang, Ralf J Sommer, Ray L Hong
Publikováno v: eLife, Vol 3 (2014)
Nematodes and insects are the two most speciose animal phyla and nematode–insect associations encompass widespread biological interactions. To dissect the chemical signals and the genes mediating this association, we investigated the effect of an o
Externí odkaz: https://doaj.org/article/6472613be8f147a0be83ee1779b9a339
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5
Patient-derived glial enriched progenitors repair functional deficits due to white matter stroke and vascular dementia in rodents
Autor: Jessica K Cinkornpumin, Emily A. Hatanaka, William E. Lowry, Ying Lin, David R. Miller, Yuan Xie, S. Thomas Carmichael, Irene L. Llorente, Jose A. Mazzitelli
Publikováno v: Science Translational Medicine. 13
Subcortical white matter stroke (WMS) accounts for up to 30% of all stroke events. WMS damages primarily astrocytes, axons, oligodendrocytes, and myelin. We hypothesized that a therapeutic intervention targeting astrocytes would be ideally suited for
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb3ae9d1f4cbce00e167b10ec32a60c7
https://doi.org/10.1126/scitranslmed.aaz6747
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6
Deletion of RBMX RGG/RG motif in Shashi-XLID syndrome leads to aberrant p53 activation and neuronal differentiation defects
Autor: Stéphane Richard, Jessica K Cinkornpumin, William A. Pastor, Zhenbao Yu, Ting Cai, Oscar D. Villarreal
Publikováno v: Cell Reports, Vol 36, Iss 2, Pp 109337-(2021)
Summary: RNA-binding proteins play important roles in X-linked intellectual disability (XLID). In this study, we investigate the contribution of the XLID-associated RBMX in neuronal differentiation. We show that RBMX-depleted cells exhibit aberrant a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83fb77d892249a2795c0c1900715b834
https://pubmed.ncbi.nlm.nih.gov/34260915
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7
Naive Human Embryonic Stem Cells Can Give Rise to Cells with a Trophoblast-like Transcriptome and Methylome
Autor: Takahiro Arima, Hsin Wei Tseng, Wanlu Liu, Jessica K Cinkornpumin, Yixin Guo, William A. Pastor, Sin Young Kwon, Thomas F. Duchaine, Jacinthe Sirois, Ishtiaque Hossain, Colleen S. Russett, Hiroaki Okae
Publikováno v: Stem Cell Reports
Summary Human embryonic stem cells (hESCs) readily differentiate to somatic or germ lineages but have impaired ability to form extra-embryonic lineages such as placenta or yolk sac. Here, we demonstrate that naive hESCs can be converted into cells th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba993b9044966e40c8f31e815a00a5ba
https://pubmed.ncbi.nlm.nih.gov/32619492
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8
Systematic optimization of an engineered hydrogel allows for selective control of human neural stem cell survival and differentiation after transplantation in the stroke brain
Autor: Jessica K Cinkornpumin, Tatiana Segura, S. Thomas Carmichael, William E. Lowry, Irene L. Llorente, Lina R. Nih, Pouria Moshayedi, Andrew R. Berg
Publikováno v: Moshayedi, P; Nih, LR; Llorente, IL; Berg, AR; Cinkornpumin, J; Lowry, WE; et al.(2016). Systematic optimization of an engineered hydrogel allows for selective control of human neural stem cell survival and differentiation after transplantation in the stroke brain. BIOMATERIALS, 105, 145-155. doi: 10.1016/j.biomaterials.2016.07.028. UCLA: Retrieved from: http://www.escholarship.org/uc/item/9t02j558
Stem cell therapies have shown promise in promoting recovery in stroke but have been limited by poor cell survival and differentiation. We have developed a hyaluronic acid (HA)-based self-polymerizing hydrogel that serves as a platform for adhesion o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f765b4d6b78a0731160d6d4b7ed2718
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9
A small molecule screen to identify regulators of let-7 targets
Autor: Michael E. Jung, Richard I. Gregory, David N. Chan, Jessica K Cinkornpumin, Xavier Gaeta, Liem H. Nguyen, William E. Lowry, Liu Xiaoguang, A. Liu, Hao Zhu, Syh-Jae Lin, Martina Roos, John P. Chute
Publikováno v: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
The let-7 family of miRNAs has been shown to be crucial in many aspects of biology, from the regulation of developmental timing to cancer. The available methods to regulate this family of miRNAs have so far been mostly genetic and therefore not easil
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1896bea7fa77b92a7045cbbab4aa0793
http://europepmc.org/articles/PMC5698460
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10
Loss of MECP2 leads to activation of p53 and neuronal senescence
Autor: Benni Vargas, Kai Fu, Masao Ohashi, Peiyee Lee, Stephen Tran, Jessica K Cinkornpumin, Matteo Pellegrini, Kathrin Plath, Denise E. Allen, Elena Korsakova, Jennifer C Park, Konstantinos Chronis, William E. Lowry, Edward Kuoy, Igal Germanguz, Carlos Salas, Xinshu Xiao
To determine the role for mutations of MECP2 in Rett Syndrome, we generated isogenic lines of human iPSCs (hiPSCs), neural progenitor cells (NPCs), and neurons from patient fibroblasts with and without MECP2 expression in an attempt to recapitulate d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38df36d44d8106366dddb5330e7f9c18
https://doi.org/10.1101/130401
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