Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Jessica K Tyler"'
Publikováno v:
eLife, Vol 13 (2024)
In response to DNA double-strand damage, ongoing transcription is inhibited to facilitate accurate DNA repair while transcriptional recovery occurs after DNA repair is complete. However, the mechanisms at play and the identity of the transcripts bein
Externí odkaz:
https://doaj.org/article/c42358d3adbe40cc8dd04ac199f88f11
Autor:
Ruben Rosas, Rhiannon R Aguilar, Nina Arslanovic, Anna Seck, Duncan J Smith, Jessica K Tyler, Mair EA Churchill
Publikováno v:
eLife, Vol 12 (2023)
The histone chaperone chromatin assembly factor 1 (CAF-1) deposits two nascent histone H3/H4 dimers onto newly replicated DNA forming the central core of the nucleosome known as the tetrasome. How CAF-1 ensures there is sufficient space for the assem
Externí odkaz:
https://doaj.org/article/62285cb04994432d93263bf4766c7de6
Autor:
Faith C Fowler, Bo-Ruei Chen, Nicholas Zolnerowich, Wei Wu, Raphael Pavani, Jacob Paiano, Chelsea Peart, Zulong Chen, André Nussenzweig, Barry P Sleckman, Jessica K Tyler
Publikováno v:
eLife, Vol 11 (2022)
DNA double-strand break (DSB) repair by homologous recombination is confined to the S and G2 phases of the cell cycle partly due to 53BP1 antagonizing DNA end resection in G1 phase and non-cycling quiescent (G0) cells where DSBs are predominately rep
Externí odkaz:
https://doaj.org/article/20fdda038d0c46f1ba37279b0a8d1e09
Autor:
Bo-Ruei Chen, Yinan Wang, Anthony Tubbs, Dali Zong, Faith C Fowler, Nicholas Zolnerowich, Wei Wu, Amelia Bennett, Chun-Chin Chen, Wendy Feng, Andre Nussenzweig, Jessica K Tyler, Barry P Sleckman
Publikováno v:
eLife, Vol 10 (2021)
DNA double-strand break (DSB) repair by homologous recombination (HR) is thought to be restricted to the S- and G2- phases of the cell cycle in part due to 53BP1 antagonizing DNA end resection in G1-phase and non-cycling quiescent (G0) cells. Here, w
Externí odkaz:
https://doaj.org/article/0d399988ea5d4729923352965a4c0d86
Publikováno v:
eLife, Vol 10 (2021)
Methionine restriction (MR) dramatically extends the healthspan of several organisms. Methionine-restricted rodents have less age-related pathology and increased longevity as compared with controls, and recent studies suggest that humans might benefi
Externí odkaz:
https://doaj.org/article/d086dd1cdb924744b92596e79bdf10b9
Autor:
Matt Kaeberlein, Jessica K Tyler
Publikováno v:
eLife, Vol 10 (2021)
eLife is publishing a special issue on aging, geroscience and longevity to mark the rapid progress made in this field over the past decade, both in terms of mechanistic understanding and translational approaches that are poised to have clinical impac
Externí odkaz:
https://doaj.org/article/b83e10ebb3fb44dfa758b3fbd2c4a1b8
Autor:
Zheng Hu, Bo Xia, Spike DL Postnikoff, Zih-Jie Shen, Alin S Tomoiaga, Troy A Harkness, Ja Hwan Seol, Wei Li, Kaifu Chen, Jessica K Tyler
Publikováno v:
eLife, Vol 7 (2018)
Translational efficiency correlates with longevity, yet its role in lifespan determination remains unclear. Using ribosome profiling, translation efficiency is globally reduced during replicative aging in budding yeast by at least two mechanisms: Fir
Externí odkaz:
https://doaj.org/article/f4bd1d018dd843abad7bcb3c16a77f25
Autor:
Li-Ting Diao, Chin-Chuan Chen, Briana Dennehey, Sangita Pal, Pingping Wang, Zie-Jie Shen, Angela Deem, Jessica K Tyler
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180556 (2017)
The DNA damage checkpoint is activated in response to DNA double-strand breaks (DSBs). We had previously shown that chromatin assembly mediated by the histone chaperone Asf1 triggers inactivation of the DNA damage checkpoint in yeast after DSB repair
Externí odkaz:
https://doaj.org/article/49e504f85aa34208bd84dc1f45943c29
Autor:
Wallace H Liu, Sarah C Roemer, Yeyun Zhou, Zih-Jie Shen, Briana K Dennehey, Jeremy L Balsbaugh, Jennifer C Liddle, Travis Nemkov, Natalie G Ahn, Kirk C Hansen, Jessica K Tyler, Mair EA Churchill
Publikováno v:
eLife, Vol 5 (2016)
The histone chaperone Chromatin Assembly Factor 1 (CAF-1) deposits tetrameric (H3/H4)2 histones onto newly-synthesized DNA during DNA replication. To understand the mechanism of the tri-subunit CAF-1 complex in this process, we investigated the prote
Externí odkaz:
https://doaj.org/article/353f970f23184f968a82624c8256ca51
Autor:
Xuan Li, Jessica K Tyler
Publikováno v:
eLife, Vol 5 (2016)
The cell achieves DNA double-strand break (DSB) repair in the context of chromatin structure. However, the mechanisms used to expose DSBs to the repair machinery and to restore the chromatin organization after repair remain elusive. Here we show that
Externí odkaz:
https://doaj.org/article/888ad57fac9e42cca1baca7d6e17de10