Zobrazeno 1 - 10
of 200
pro vyhledávání: '"Jessica K Tyler"'
Publikováno v:
eLife, Vol 13 (2024)
In response to DNA double-strand damage, ongoing transcription is inhibited to facilitate accurate DNA repair while transcriptional recovery occurs after DNA repair is complete. However, the mechanisms at play and the identity of the transcripts bein
Externí odkaz:
https://doaj.org/article/c42358d3adbe40cc8dd04ac199f88f11
Autor:
Ruben Rosas, Rhiannon R Aguilar, Nina Arslanovic, Anna Seck, Duncan J Smith, Jessica K Tyler, Mair EA Churchill
Publikováno v:
eLife, Vol 12 (2023)
The histone chaperone chromatin assembly factor 1 (CAF-1) deposits two nascent histone H3/H4 dimers onto newly replicated DNA forming the central core of the nucleosome known as the tetrasome. How CAF-1 ensures there is sufficient space for the assem
Externí odkaz:
https://doaj.org/article/62285cb04994432d93263bf4766c7de6
Autor:
Zulong Chen, Jessica K. Tyler
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
DNA double-strand breaks (DSBs), the most deleterious DNA lesions, are primarily repaired by two pathways, namely homologous recombination (HR) and non-homologous end joining (NHEJ), the choice of which is largely dependent on cell cycle phase and th
Externí odkaz:
https://doaj.org/article/a181afdfb6534971a0e6931cbf862e53
Autor:
Faith C Fowler, Bo-Ruei Chen, Nicholas Zolnerowich, Wei Wu, Raphael Pavani, Jacob Paiano, Chelsea Peart, Zulong Chen, André Nussenzweig, Barry P Sleckman, Jessica K Tyler
Publikováno v:
eLife, Vol 11 (2022)
DNA double-strand break (DSB) repair by homologous recombination is confined to the S and G2 phases of the cell cycle partly due to 53BP1 antagonizing DNA end resection in G1 phase and non-cycling quiescent (G0) cells where DSBs are predominately rep
Externí odkaz:
https://doaj.org/article/20fdda038d0c46f1ba37279b0a8d1e09
Autor:
Bo-Ruei Chen, Yinan Wang, Anthony Tubbs, Dali Zong, Faith C Fowler, Nicholas Zolnerowich, Wei Wu, Amelia Bennett, Chun-Chin Chen, Wendy Feng, Andre Nussenzweig, Jessica K Tyler, Barry P Sleckman
Publikováno v:
eLife, Vol 10 (2021)
DNA double-strand break (DSB) repair by homologous recombination (HR) is thought to be restricted to the S- and G2- phases of the cell cycle in part due to 53BP1 antagonizing DNA end resection in G1-phase and non-cycling quiescent (G0) cells. Here, w
Externí odkaz:
https://doaj.org/article/0d399988ea5d4729923352965a4c0d86
Publikováno v:
Methods and Protocols, Vol 5, Iss 5, p 79 (2022)
Until recently, the favored method for making directed modifications to the budding yeast genome involved the introduction of a DNA template carrying the desired genetic changes along with a selectable marker, flanked by homology arms. This approach
Externí odkaz:
https://doaj.org/article/b5d54cbca0084d7688815a9c7810799a
Publikováno v:
eLife, Vol 10 (2021)
Methionine restriction (MR) dramatically extends the healthspan of several organisms. Methionine-restricted rodents have less age-related pathology and increased longevity as compared with controls, and recent studies suggest that humans might benefi
Externí odkaz:
https://doaj.org/article/d086dd1cdb924744b92596e79bdf10b9
Autor:
Matt Kaeberlein, Jessica K Tyler
Publikováno v:
eLife, Vol 10 (2021)
eLife is publishing a special issue on aging, geroscience and longevity to mark the rapid progress made in this field over the past decade, both in terms of mechanistic understanding and translational approaches that are poised to have clinical impac
Externí odkaz:
https://doaj.org/article/b83e10ebb3fb44dfa758b3fbd2c4a1b8
Autor:
Faith C. Fowler, Jessica K. Tyler
Publikováno v:
Methods and Protocols, Vol 5, Iss 1, p 3 (2021)
After a DNA double-strand break, cells utilize either non-homologous end joining or homologous recombination to repair the broken DNA ends. Homologous recombination requires extensive nucleolytic processing of one of the DNA strands, resulting in lon
Externí odkaz:
https://doaj.org/article/8172da726f6d41c3b549cb3f9d8af0d8
Publikováno v:
Microbial Cell, Vol 4, Iss 11, Pp 368-375 (2017)
Aging is a complex, multi-factorial biological process shared by all living organisms. It is manifested by a gradual accumulation of molecular alterations that lead to the decline of normal physiological functions in a time-dependent fashion. The ult
Externí odkaz:
https://doaj.org/article/a98dd079388a4267a877ba81afdea0c6