Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jessica K Fiege"'
Autor:
Jessica K Fiege, Joshua M Thiede, Hezkiel Arya Nanda, William E Matchett, Patrick J Moore, Noe Rico Montanari, Beth K Thielen, Jerry Daniel, Emma Stanley, Ryan C Hunter, Vineet D Menachery, Steven S Shen, Tyler D Bold, Ryan A Langlois
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009292 (2021)
The human airway epithelium is the initial site of SARS-CoV-2 infection. We used flow cytometry and single cell RNA-sequencing to understand how the heterogeneity of this diverse cell population contributes to elements of viral tropism and pathogenes
Externí odkaz:
https://doaj.org/article/68102c0c4b2f4a7984aa55fb2d7b97a4
Autor:
Jessica K Fiege, Ian A Stone, Rebekah E Dumm, Barbara M Waring, Brian T Fife, Judith Agudo, Brian D Brown, Nicholas S Heaton, Ryan A Langlois
Publikováno v:
PLoS Pathogens, Vol 15, Iss 9, p e1008077 (2019)
Influenza A virus (IAV) is a seasonal pathogen with the potential to cause devastating pandemics. IAV infects multiple epithelial cell subsets in the respiratory tract, eliciting damage to the lungs. Clearance of IAV is primarily dependent on CD8+ T
Externí odkaz:
https://doaj.org/article/3abedd6189e14d2cba46d2013be0f6b3
Autor:
Autumn E. Sanders, Henriette Arnesen, Frances K. Shepherd, Dira S. Putri, Jessica K. Fiege, Mark J. Pierson, Shanley N. Roach, Harald Carlsen, David Masopust, Preben Boysen, Ryan A. Langlois
Publikováno v:
mSphere, Vol 9, Iss 2 (2024)
ABSTRACT Specific pathogen-free (SPF) laboratory mice dominate preclinical studies for immunology and vaccinology. Unfortunately, SPF mice often fail to accurately model human responses to vaccination and other immunological perturbations. Several gr
Externí odkaz:
https://doaj.org/article/87adcac41ea74783bc1ecd64e40dff96
Autor:
Rebekah E. Dumm, Jessica K. Fiege, Barbara M. Waring, Chay T. Kuo, Ryan A. Langlois, Nicholas S. Heaton
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Infection of a cell with influenza B virus (IBV) often results in cell death and the role of surviving cells in pathogenesis is unclear. Here, Dumm et al. generate a recombinant IBV that activates a host-cell reporter to permanently label infected ce
Externí odkaz:
https://doaj.org/article/9031272241854e39a95eb61c490bdf38
Autor:
Beth K Thielen, Jessica K. Fiege, Mari Shiratori, Clayton K. Mickelson, Ryan A. Langlois, Luis B. Barreiro, João Barroso-Batista, Haley E. Randolph
Publikováno v:
Science. 374:1127-1133
Humans differ in their susceptibility to infectious disease, partly owing to variation in the immune response after infection. We used single-cell RNA sequencing to quantify variation in the response to influenza infection in peripheral blood mononuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6608071dbbf30ffa222fe23fb7d85e58
https://doi.org/10.1126/science.abg0928
https://doi.org/10.1126/science.abg0928
Autor:
Jessica K. Fiege, Ryan A. Langlois
Publikováno v:
The Journal of general virology. 103(6)
Animal models are a critical tool in modern biology. To increase reproducibility and to reduce confounding variables modern animal models exclude many microbes, including key natural commensals and pathogens. Here we discuss recent strategies to inco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a73da9961a181069ce8b2872ea8b6e2
https://pubmed.ncbi.nlm.nih.gov/35737518
https://pubmed.ncbi.nlm.nih.gov/35737518
Autor:
Shanley N. Roach, Jessica K. Fiege, Frances K. Shepherd, Talia D. Wiggen, Ryan C. Hunter, Ryan A. Langlois
Publikováno v:
J Virol
Influenza A viruses (IAV) can cause severe disease and death in humans. IAV infection and the accompanying immune response can result in systemic inflammation, leading to intestinal damage and disruption of the intestinal microbiome. Here, we demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49990b46b742a4ecb9bc5b83560ad807
https://doi.org/10.1128/jvi.00352-22
https://doi.org/10.1128/jvi.00352-22
Autor:
Sathi Wijeyesinghe, Matthew W. Markman, David Masopust, Marissa Macchietto, Ian A. Stone, Ryan A. Langlois, Steven S. Shen, Jessica K. Fiege, Elizabeth J. Fay
Publikováno v:
J Immunol
Resident memory T cells (TRM) in the lung are vital for heterologous protection against influenza A virus (IAV). Environmental factors are necessary to establish lung TRM; however, the role of T cell–intrinsic factors like TCR signal strength have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc4868f1b26f2f30b51f354f136f24a9
https://doi.org/10.4049/jimmunol.1900093
https://doi.org/10.4049/jimmunol.1900093
Autor:
Zepeng Mu, Jessica K. Fiege, Haley E. Randolph, Mari Cobb, Beth K Thielen, Julie Hussein, Ryan A. Langlois, Jean-Christophe Grenier, Yang I. Li, Luis B. Barreiro
Humans vary in their susceptibility to infectious disease, partly due to variation in the immune response following infection. Here, we used single-cell RNA-sequencing to quantify genetic contributions to this variation in peripheral blood mononuclea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4488fb254cd07e1bf12092a85d6f661
https://doi.org/10.1101/2020.12.21.423830
https://doi.org/10.1101/2020.12.21.423830
Autor:
Tyler D. Bold, Jessica K. Fiege, Ryan A. Langlois, Thomas J. Gniadek, Abigail R Gress, William E. Matchett, Marc K. Jenkins, Kathryn A. Pape, Joshua M. Thiede, Vineet D. Menachery
Publikováno v:
Transfusion
bioRxiv
bioRxiv
BACKGROUND: The transfer of passive immunity with convalescent plasma is a promising strategy for treatment and prevention of COVID-19, but donors with a history of nonsevere disease are serologically heterogenous. The relationship between SARS-Cov-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::503109af3ab0e302b1e042bde4e03429
https://europepmc.org/articles/PMC7995753/
https://europepmc.org/articles/PMC7995753/