Network proximity analysis as a theoretical model for identifying potential novel therapies in primary sclerosing cholangitis

Autor: Jessica Leighton, David E. J. Jones, Jessica K. Dyson, Heather J. Cordell

Publikováno v: BMC Medical Genomics, Vol 17, Iss 1, Pp 1-13 (2024)

Abstract Primary Sclerosing Cholangitis (PSC) is a progressive cholestatic liver disease with no licensed therapies. Previous Genome Wide Association Studies (GWAS) have identified genes that correlate significantly with PSC, and these were identifie

Externí odkaz: https://doaj.org/article/c1bcbcd837f34175b375f4daaba3d662

The relationship between disease activity and UDCA response criteria in primary biliary cholangitis: A cohort study

Autor: David E.J. Jones, Aaron Wetten, Ben Barron-Millar, Laura Ogle, George Mells, Steven Flack, Richard Sandford, John Kirby, Jeremy Palmer, Sophie Brotherston, Laura Jopson, John Brain, Graham R. Smith, Steve Rushton, Rebecca Jones, Simon Rushbrook, Douglas Thorburn, Stephen D. Ryder, Gideon Hirschfield, Jessica K. Dyson

Publikováno v: EBioMedicine, Vol 80, Iss , Pp 104068- (2022)

Summary: Background: Uncertainty exists about how best to identify primary biliary cholangitis (PBC) patients who would benefit from second-line therapy. Existing, purely clinical, ursodeoxycholic acid (UDCA) response criteria accept degrees of liver

Externí odkaz: https://doaj.org/article/39a878808f5b4982bbbea7ab6978ff11

Anti-Cholestatic Therapy with Obeticholic Acid Improves Short-Term Memory in Bile Duct-Ligated Mice

Autor: Lucy M.V. Gee, Ben Barron-Millar, Jack Leslie, Claire Richardson, Marco Y.W. Zaki, Saimir Luli, Rachel A. Burgoyne, Rainie I.T. Cameron, Graham R. Smith, John G. Brain, Barbara Innes, Laura Jopson, Jessica K. Dyson, Katherine R.C. McKay, Alexandros Pechlivanis, Elaine Holmes, Rolando Berlinguer-Palmini, Stella Victorelli, George F. Mells, Richard N. Sandford, Jeremy Palmer, John A. Kirby, Christos Kiourtis, Joao Mokochinski, Zoe Hall, Thomas G. Bird, Lee A. Borthwick, Christopher M. Morris, Peter S. Hanson, Diana Jurk, Elizabeth A. Stoll, Fiona E.N. LeBeau, David E.J. Jones, Fiona Oakley

Publikováno v: Gee, L M V, Barron-Millar, B, Leslie, J, Richardson, C, Zaki, M Y W, Luli, S, Burgoyne, R, Cameron, R I T, Smith, G R, Brain, J G, Innes, B, Jopson, L, Dyson, J K, McKay, K R C, Pechlivanis, A, Holmes, E, Berlinguer-Palmini, R, Victorelli, S, Mells, G F, Sandford, R N, Palmer, J, Kirby, J, Kiourtis, C, Mokochinski, J, Hall, Z, Bird, T G, Borthwick, L A, Morris, C, Hanson, P, Jurk, D, Stoll, E, LeBeau, F, Jones, D & Oakley, F 2022, ' Anti-Cholestatic therapy with Obeticholic Acid improves short term memory in bile duct ligated mice ', The American Journal of Pathology . https://doi.org/10.1016/j.ajpath.2022.09.005

Patients with cholestatic liver disease, including those with primary biliary cholangitis, can experience symptoms of impaired cognition or brain fog. This phenomenon remains unexplained and is currently untreatable. Bile duct ligation (BDL) is an es

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a70d70f37cc3ec34fd9fc440f82313fc

Implementation of a care bundle improves the management of patients with non-alcoholic fatty liver disease

Autor: Subashini Chandrapalan, Jessica K Dyson, Laura Haigh, William Taylor, Stuart McPherson, Mohammed Hussien, Sophia Oxenburgh, Quentin M. Anstee, Naw April Phaw, Kate Hallsworth, Timothy Hardy, Steven Masson, David Beaton, Sarah Galbraith, Dina Mansour, Shi Looi, Louise Macdougall, Phey Shen Lee, Alaa Ebraheem, Laura J Neilson

Publikováno v: Frontline Gastroenterology

BackgroundNon-alcoholic fatty liver disease (NAFLD) is common and is associated with liver-related and cardiovascular-related morbidity. Our aims were: (1) to review the current management of patients with NAFLD attending hospital clinics in North Ea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a6e3ba861884a040c720bac2cfe7a4
http://europepmc.org/articles/PMC8640379

Pregnancy outcomes in women with liver transplants: systematic review and meta-analysis

Autor: Sivesh K. Kamarajah, Jessica K Dyson, Ella J Marson, Steven A. White

Publikováno v: HPB. 22:1102-1111

Background Despite increasing reports of pregnancy in liver transplant recipients, questions remain about the impact of transplantation in pregnancy. Methods This systematic review was performed according to PRISMA guidelines and eligible studies wer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c3553b5afc2b27693bffbfd35c6eb3c
https://doi.org/10.1016/j.hpb.2020.05.001