The Current Status and Work of Three Rs Centres and Platforms in Europe*

Autor: Winfried Neuhaus, Birgit Reininger-Gutmann, Beate Rinner, Roberto Plasenzotti, Doris Wilflingseder, Joery De Kock, Tamara Vanhaecke, Vera Rogiers, Dagmar Jírová, Kristina Kejlová, Lisbeth E. Knudsen, Rasmus Normann Nielsen, Burkhard Kleuser, Vivian Kral, Christa Thöne-Reineke, Thomas Hartung, Giorgia Pallocca, Costanza Rovida, Marcel Leist, Stefan Hippenstiel, Annemarie Lang, Ida Retter, Stephanie Krämer, Peter Jedlicka, Katharina Ameli, Ellen Fritsche, Julia Tigges, Eliška Kuchovská, Manuela Buettner, Andre Bleich, Nadine Baumgart, Jan Baumgart, Marcus W. Meinhardt, Rainer Spanagel, Sabine Chourbaji, Bettina Kränzlin, Bettina Seeger, Maren von Köckritz-Blickwede, José M. Sánchez-Morgado, Viola Galligioni, Daniel Ruiz-Pérez, Dania Movia, Adriele Prina-Mello, Arti Ahluwalia, Valeria Chiono, Arno C. Gutleb, Marthe Schmit, Bea van Golen, Leane van Weereld, Anne Kienhuis, Erica van Oort, Jan van der Valk, Adrian Smith, Joanna Roszak, Maciej Stępnik, Zuzanna Sobańska, Edyta Reszka, I. Anna S. Olsson, Nuno Henrique Franco, Bogdan Sevastre, Helena Kandarova, Sara Capdevila, Jessica Johansson, Emma Svensk, Christopher R. Cederroth, Jenny Sandström, Ian Ragan, Nataliia Bubalo, Jens Kurreck, Horst Spielmann

Publikováno v: Alternatives to Laboratory Animals. 50:381-413

The adoption of Directive 2010/63/EU on the protection of animals used for scientific purposes has given a major push to the formation of Three Rs initiatives in the form of centres and platforms. These centres and platforms are dedicated to the so-c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc36c6df121407af00ec21546f6f685f
https://doi.org/10.1177/02611929221140909

The Rise of Three Rs Centres and Platforms in Europe

Autor: Winfried Neuhaus, Birgit Reininger-Gutmann, Beate Rinner, Roberto Plasenzotti, Doris Wilflingseder, Joery De Kock, Tamara Vanhaecke, Vera Rogiers, Dagmar Jírová, Kristina Kejlová, Lisbeth E. Knudsen, Rasmus Normann Nielsen, Burkhard Kleuser, Vivian Kral, Christa Thöne-Reineke, Thomas Hartung, Giorgia Pallocca, Marcel Leist, Stefan Hippenstiel, Annemarie Lang, Ida Retter, Stephanie Krämer, Peter Jedlicka, Katharina Ameli, Ellen Fritsche, Julia Tigges, Manuela Buettner, Andre Bleich, Nadine Baumgart, Jan Baumgart, Marcus W. Meinhardt, Rainer Spanagel, Sabine Chourbaji, Bettina Kränzlin, Bettina Seeger, Maren von Köckritz-Blickwede, José M. Sánchez-Morgado, Viola Galligioni, Daniel Ruiz-Pérez, Dania Movia, Adriele Prina-Mello, Arti Ahluwalia, Valeria Chiono, Arno C. Gutleb, Marthe Schmit, Bea van Golen, Leane van Weereld, Anne Kienhuis, Erica van Oort, Jan van der Valk, Adrian Smith, Joanna Roszak, Maciej Stępnik, Zuzanna Sobańska, I. Anna S. Olsson, Nuno Henrique Franco, Bogdan Sevastre, Helena Kandarova, Sara Capdevila, Jessica Johansson, Christopher R. Cederroth, Jenny Sandström, Ian Ragan, Nataliia Bubalo, Horst Spielmann

Publikováno v: ATLA-ALTERNATIVES TO LABORATORY ANIMALS
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
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Public awareness and discussion about animal experiments and replacement methods has greatly increased in recent years. The term ‘the Three Rs’, which stands for the Replacement, Reduction and Refinement of animal experiments, is inseparably link

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01736f127bcfc51bf6af214ad3a3d859
https://pubmed.ncbi.nlm.nih.gov/35578444

Proinflammatory Cytokines and Oxidative Stress Decrease the Transport of Dopamine Precursor Tyrosine in Human Fibroblasts

Autor: Nikolaos Venizelos, Ravi Vumma, Jessica Johansson

Publikováno v: Neuropsychobiology. 75:178-184

Background: Proinflammatory cytokines and oxidative stress responses have been extensively implicated in the pathophysiology of neuropsychiatric disorders over the past 2 decades. Moreover, disturbed transport of the dopamine precursor (i.e., the ami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbbda17167d08fc813a6d45f9e35b36e
https://doi.org/10.1159/000485130

Genetic and Functional Study of L-Type Amino Acid Transporter 1 in Schizophrenia

Autor: Erika Comasco, Tommy Lewander, Nikolaos Venizelos, Lena Flyckt, Lars Bjerkenstedt, Erik Söderman, Lars Oreland, Dimitrios Andreou, Ingrid Agartz, Erik G. Jönsson, Simone Toffoletto, Lars Terenius, Jessica Johansson, Ravi Vumma

Publikováno v: Neuropsychobiology. 74:96-103

Schizophrenia involves neural catecholaminergic dysregulation. Tyrosine is the precursor of catecholamines, and its major transporter, according to studies on fibroblasts, in the brain is the L-type amino acid transporter 1 (LAT1). The present study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5cade2b581ada979ea3f1b64c482e55a
https://doi.org/10.1159/000455234

Abstracts of Award-Winning Posters, 16th International Forum on Mood and Anxiety Disorders, Rome, December 8-10, 2016

Autor: Adrian Andrzej Chrobak, Dena Sadeghi Bahmani, Erika Comasco, Erik G. Jönsson, Erik Söderman, Janusz K. Rybakowski, Hiroaki Jitsuiki, R. Michael Bagby, Dominika Dudek, Mohammad Ahmadpanah, Satz Mengensatzproduktion, Lena Flyckt, Masahiro Takamura, Lars Oreland, Dimitrios Andreou, Anjali Janardhanan, Daniela S.S. Lobo, Tetsuya Yamamoto, Livia Voneschen, Kazuo Awai, Marzieh Nazaribadie, Mohammad Haghighi, Akiko Kurata, Lars Terenius, Anjana Sadanand, Jens Gaab, Yoko Kaichi, Ewa Dopierala, Marcin Siwek, Anna Tereszko, Druckerei Stückle, Mehran Shayganfard, Osamu Yamamoto, Julia Jiménez, Edith Holsboer-Trachsler, Daniel Oschwald, Serge Brand, Yuji Akiyama, Simone Toffoletto, Tatsuji Tamura, Arambakkam Janardhanam Vanisree, Andrea H. Meyer, Urs M. Nater, Hafez Bajoghli, Lena C. Quilty, Victoria S. Marshe, Ewa Ferensztajn-Rochowiak, Ingrid Agartz, Shigeru Toki, Yasumasa Okamoto, Peter Krummenacher, Jan Jaracz, Daniel J. Müller, N. Yokota, Jessica Johansson, Ravi Vumma, Kate L. Harkness, Flávio Kapczinski, Lars Bjerkenstedt, Tommy Lewander, Leila Jahangard, Shigeto Yamawaki, Michał Michalak, Nikolaos Venizelos, Go Okada

Publikováno v: Neuropsychobiology. 74(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df63648f2ed0bfaac741ed07fa6aaee9
https://pubmed.ncbi.nlm.nih.gov/28178693