Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Jessica J. Jowais"'
1
Akademický článek
PUFA stabilizes a conductive state of the selectivity filter in IKs channels
Autor: Alessia Golluscio, Jodene Eldstrom, Jessica J Jowais, Marta Elena Perez, Kevin Peter Cunningham, Alicia De La Cruz, Xiaoan Wu, Valentina Corradi, D Peter Tieleman, David Fedida, H Peter Larsson
Publikováno v: eLife, Vol 13 (2024)
In cardiomyocytes, the KCNQ1/KCNE1 channel complex mediates the slow delayed-rectifier current (IKs), pivotal during the repolarization phase of the ventricular action potential. Mutations in IKs cause long QT syndrome (LQTS), a syndrome with a prolo
Externí odkaz: https://doaj.org/article/3b70b86ed7a5417386c6095c41baafa2
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2
Akademický článek
Mechanistic insights into robust cardiac IKs potassium channel activation by aromatic polyunsaturated fatty acid analogues
Autor: Briana M Bohannon, Jessica J Jowais, Leif Nyberg, Vanessa Olivier-Meo, Valentina Corradi, D Peter Tieleman, Sara I Liin, H Peter Larsson
Publikováno v: eLife, Vol 12 (2023)
Voltage-gated potassium (KV) channels are important regulators of cellular excitability and control action potential repolarization in the heart and brain. KV channel mutations lead to disordered cellular excitability. Loss-of-function mutations, for
Externí odkaz: https://doaj.org/article/7551a63ea06f42c399ecf18db23a441f
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4
Akademický článek
Polyunsaturated fatty acid analogues differentially affect cardiac NaV, CaV, and KV channels through unique mechanisms
Autor: Briana M Bohannon, Alicia de la Cruz, Xiaoan Wu, Jessica J Jowais, Marta E Perez, Derek M Dykxhoorn, Sara I Liin, H Peter Larsson
Publikováno v: eLife, Vol 9 (2020)
The cardiac ventricular action potential depends on several voltage-gated ion channels, including NaV, CaV, and KV channels. Mutations in these channels can cause Long QT Syndrome (LQTS) which increases the risk for ventricular fibrillation and sudde
Externí odkaz: https://doaj.org/article/e07a4e0605884ed9905949525bae0d17
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5
Mechanistic insights into robust cardiac IKspotassium channel activation by aromatic polyunsaturated fatty acid analogues
Autor: Briana M. Bohannon, Jessica J. Jowais, Leif Nyberg, Sara I. Liin, H. Peter Larsson
Voltage-gated potassium (KV) channels are important regulators of cellular excitability and control action potential repolarization in the heart and brain. KVchannel mutations lead to disordered cellular excitability. Loss-of-function mutations, for
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::03986ba4b524b6f111dc26714b02f583
https://doi.org/10.1101/2023.01.12.523777
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8
Polyunsaturated fatty acid analogues differentially affect cardiac NaV, CaV, and KV channels through unique mechanisms
Autor: Sara I. Liin, Jessica J Jowais, Derek M. Dykxhoorn, Xiaoan Wu, Marta E. Perez, Briana M. Bohannon, Hans Peter Larsson, Alicia de la Cruz
Publikováno v: eLife, Vol 9 (2020)
eLife
The cardiac ventricular action potential depends on several voltage-gated ion channels, including Na-V, Ca-V, and K-V channels. Mutations in these channels can cause Long QT Syndrome (LQTS) which increases the risk for ventricular fibrillation and su
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e32aacfc3b510bd4c28f8e2c2bc0f1f3
https://elifesciences.org/articles/51453
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Plný text Recenzováno Digitální knihovna AV ČR
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