Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Jessica J. Hung"'
Autor:
Tony Y. Shay, Carl A. Karouta, Ayush Sharma, Amjad Chowdhury, Jessica J. Hung, Keith P. Johnston, Maria P. Nieto, Kishan Ramachandran, Logan R. Wilks, Barton J. Dear, Thomas M. Truskett, Jason K. Cheung
Publikováno v:
Industrial & Engineering Chemistry Research. 58:22456-22471
To understand and predict the viscosities of highly concentrated monoclonal antibody (mAb) solutions, it is important to characterize the protein–protein interactions (PPI) and how they influence t...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6e2a159f2a08f08392b26692f736a02
https://doi.org/10.1021/acs.iecr.9b03432
https://doi.org/10.1021/acs.iecr.9b03432
Autor:
Logan R. Wilks, Joshua R. Laber, Keith P. Johnston, Jessica J. Hung, Thomas M. Truskett, Barton J. Dear, Ayush Sharma
Publikováno v:
Journal of Pharmaceutical Sciences. 108:2517-2526
An understanding of how cosolutes affect the viscosity and storage stability of highly concentrated mAbs as a function of protein-protein interactions (PPIs) would be desirable for improving processing and administration of protein therapeutics. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a6695735f0c6472d8eda9b5a041a0d
https://doi.org/10.1016/j.xphs.2019.03.008
https://doi.org/10.1016/j.xphs.2019.03.008
Autor:
Jason K. Cheung, Tony Y. Shay, Thomas M. Truskett, Carl C. Hayden, Maria P. Nieto, Barton J. Dear, Carl A. Karouta, Wade F. Zeno, Keith P. Johnston, Amjad Chowdhury, Jeanne C. Stachowiak, Jessica J. Hung, Kishan Ramachandran
Publikováno v:
Soft Matter. 15:6660-6676
The dynamic behavior of monoclonal antibodies (mAbs) at high concentration provides insight into protein microstructure and protein-protein interactions (PPI) that influence solution viscosity and protein stability. At high concentration, interpretat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e66f4db2c89ca7b3bdce0c4f43f8e98e
https://doi.org/10.1039/c9sm01071h
https://doi.org/10.1039/c9sm01071h
Autor:
P. Douglas Godfrin, Jessica J. Hung, Tony Y. Shay, Jason K. Cheung, Ayush Sharma, Keith P. Johnston, Maria P. Nieto, Amjad Chowdhury, Thomas M. Truskett, Dmytro Nykypanchuk, Jonathan A. Bollinger, Barton J. Dear, Carl A. Karouta, Kishan Ramachandran, Logan R. Wilks
Publikováno v:
The journal of physical chemistry. B. 123(25)
Attractive protein?protein interactions (PPI) in concentrated monoclonal antibody (mAb) solutions may lead to reversible oligomers (clusters) that impact colloidal stability and viscosity. Herein, the PPI are tuned for two mAbs via the addition of ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb07e838aca0990d52e38a8794c881ed
https://pubmed.ncbi.nlm.nih.gov/31146525
https://pubmed.ncbi.nlm.nih.gov/31146525
Autor:
Jonathan A. Bollinger, Jason K. Cheung, P. Douglas Godfrin, Amjad Chowdhury, Barton J. Dear, Thomas M. Truskett, Ayush Sharma, Jessica J. Hung, Kishan Ramachandran, Keith P. Johnston, Tony Y. Shay, Carl A. Karouta, Maria P. Nieto, Logan R. Wilks
Publikováno v:
The journal of physical chemistry. B. 123(4)
The ability to design and formulate mAbs to minimize attractive interactions at high concentrations is important for protein processing, stability, and administration, particularly in subcutaneous delivery, where high viscosities are often challengin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ae31138bd751a62e26da14ac86505d
https://pubmed.ncbi.nlm.nih.gov/30614707
https://pubmed.ncbi.nlm.nih.gov/30614707
Autor:
Jingyan Yue, Barton J. Dear, Aileen K. Dinin, Jessica J. Hung, Brian K. Wilson, April Twu, Ameya Borwankar, Thomas M. Truskett, Jennifer A. Maynard, Keith P. Johnston
Publikováno v:
Industrial & Engineering Chemistry Research. 55:11225-11234
To further advance a subcutaneous injection of monoclonal antibodies (mAbs) at elevated concentrations, novel concepts are needed to lower the viscosity. The addition of high concentrations of cosolutes, namely, arginine glutamate (Arg·Glu) or Arg·
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2efd322ae7ed6de0121529a2263ba619
https://doi.org/10.1021/acs.iecr.6b02042
https://doi.org/10.1021/acs.iecr.6b02042
Publikováno v:
Journal of Membrane Science. 508:113-126
During production of concentrated monoclonal antibody formulations by tangential flow ultrafiltration (TFF), high viscosities and aggregation often cause extensive membrane fouling, flux decay and low product yields. To address these challenges, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c0a57c96278949471b27a1f85dcaab2
Autor:
Ameya Borwankar, Thomas T Truskett, Barton J. Dear, Jessica J. Hung, Aileen K. Dinin, Sumarth K. Mehta, Keith P. Johnston
Publikováno v:
Pharmaceutical research. 35(7)
To explain the effects of the osmolyte proline on the protein-protein interactions (PPI), viscosity and stability of highly concentrated antibody solutions in contrast to other neutral osmolytes. The viscosity of ~225 mg/mL mAb solutions was measured
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba76e937b5e6a82f77e68f2e0a18d830
https://pubmed.ncbi.nlm.nih.gov/29713822
https://pubmed.ncbi.nlm.nih.gov/29713822
Autor:
Robert J. Stover, Jessica J. Hung, April Twu, Thomas E. Milner, Brian Willsey, Marc D. Feldman, Tianyi W. Wang, Keith P. Johnston, Ameya Borwankar, Thomas M. Truskett
Publikováno v:
RSC Advances. 5:104674-104687
Plasmonic nanoparticles with sizes well below 100 nm and high near infrared (NIR) extinction are of great interest in biomedical imaging. Herein we present ∼60 nm Au nanoparticles with high NIR absorbance at wavelengths ranging from 700 nm to 1100
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd3d77da2aa8169f094e659f71ee2b02
https://doi.org/10.1039/c5ra21712a
https://doi.org/10.1039/c5ra21712a
Publikováno v:
Pharmaceutical research. 34(1)
To explain the effects of cationic amino acids and other co-solutes on the viscosity, stability and protein-protein interactions (PPI) of highly concentrated (≥200 mg/ml) monoclonal antibody (mAb) solutions to advance subcutaneous injection. The vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::636315e28871e5a3119640e130aba011
https://pubmed.ncbi.nlm.nih.gov/27837522
https://pubmed.ncbi.nlm.nih.gov/27837522