Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jessica J. Huck"'
Autor:
Jeffrey A. Ecsedy, Wen Chyi Shyu, Mark G. Manfredi, Andy Dorner, Vaishali Shinde, Karuppiah Kannan, Marc L. Hyer, Rob Kleinfield, Xiaofei Zhou, Karthik Venkatakrishnan, Arijit Chakravarty, Jerome Mettetal, Mengkun Zhang, Jessica J. Huck
Supplementary Figure 1. Sample simulated time-course of paclitaxel and MLN8237 PK after and the pharmacokinetic parameters used for MLN8237 and paclitaxel required to generate the exposure - efficacy model. Supplementary Figure 2. Predicted versus ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27c3cf2abd203d9ceb9145431611b4a5
https://doi.org/10.1158/1535-7163.22501740
https://doi.org/10.1158/1535-7163.22501740
Autor:
Todd B. Sells, Christopher F. Claiborne, Joseph B. Bolen, Melissa S. Germanos, Matthew D. Silva, Rachel E. Gershman, Patrick J. LeRoy, Marc L. Hyer, David A. Janowick, Deborah R. Wysong, Jessica J. Huck, Vaishali Shinde, Wei Chen, Stephen G. Stroud, Kara M. Hoar, Mengkun Zhang, Lee Silverman, Arijit Chakravarty, Jeffrey A. Ecsedy, Mark G. Manfredi
PDF file - 34K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd0a58f7cbd736328e57e7a23f7e5ec
https://doi.org/10.1158/1078-0432.22446309.v1
https://doi.org/10.1158/1078-0432.22446309.v1
Autor:
Todd B. Sells, Christopher F. Claiborne, Joseph B. Bolen, Melissa S. Germanos, Matthew D. Silva, Rachel E. Gershman, Patrick J. LeRoy, Marc L. Hyer, David A. Janowick, Deborah R. Wysong, Jessica J. Huck, Vaishali Shinde, Wei Chen, Stephen G. Stroud, Kara M. Hoar, Mengkun Zhang, Lee Silverman, Arijit Chakravarty, Jeffrey A. Ecsedy, Mark G. Manfredi
Purpose: Small-molecule inhibitors of Aurora A (AAK) and B (ABK) kinases, which play important roles in mitosis, are currently being pursued in oncology clinical trials. We developed three novel assays to quantitatively measure biomarkers of AAK inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad2b8c17037133a1bc1c17abc8089fa3
https://doi.org/10.1158/1078-0432.c.6520713
https://doi.org/10.1158/1078-0432.c.6520713
Autor:
Todd B. Sells, Christopher F. Claiborne, Joseph B. Bolen, Melissa S. Germanos, Matthew D. Silva, Rachel E. Gershman, Patrick J. LeRoy, Marc L. Hyer, David A. Janowick, Deborah R. Wysong, Jessica J. Huck, Vaishali Shinde, Wei Chen, Stephen G. Stroud, Kara M. Hoar, Mengkun Zhang, Lee Silverman, Arijit Chakravarty, Jeffrey A. Ecsedy, Mark G. Manfredi
PDF file - 27K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::889d43f96b1d811fca5e3c164e018a19
https://doi.org/10.1158/1078-0432.22446306
https://doi.org/10.1158/1078-0432.22446306
Autor:
Todd B. Sells, Christopher F. Claiborne, Joseph B. Bolen, Melissa S. Germanos, Matthew D. Silva, Rachel E. Gershman, Patrick J. LeRoy, Marc L. Hyer, David A. Janowick, Deborah R. Wysong, Jessica J. Huck, Vaishali Shinde, Wei Chen, Stephen G. Stroud, Kara M. Hoar, Mengkun Zhang, Lee Silverman, Arijit Chakravarty, Jeffrey A. Ecsedy, Mark G. Manfredi
PDF file - 65K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9737acec25fe2137ea4f1aa5f53a36c5
https://doi.org/10.1158/1078-0432.22446312.v1
https://doi.org/10.1158/1078-0432.22446312.v1
Autor:
Todd B. Sells, Christopher F. Claiborne, Joseph B. Bolen, Melissa S. Germanos, Matthew D. Silva, Rachel E. Gershman, Patrick J. LeRoy, Marc L. Hyer, David A. Janowick, Deborah R. Wysong, Jessica J. Huck, Vaishali Shinde, Wei Chen, Stephen G. Stroud, Kara M. Hoar, Mengkun Zhang, Lee Silverman, Arijit Chakravarty, Jeffrey A. Ecsedy, Mark G. Manfredi
PDF file - 36K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29fa6e54e4641152cddff0837b8a5697
https://doi.org/10.1158/1078-0432.22446315
https://doi.org/10.1158/1078-0432.22446315
Autor:
Mark G. Manfredi, Jeffrey A. Ecsedy, Kristan A. Meetze, Suresh K. Balani, Olga Burenkova, Wei Chen, Katherine M. Galvin, Kara M. Hoar, Jessica J. Huck, Patrick J. LeRoy, Emily T. Ray, Todd B. Sells, Bradley Stringer, Stephen G. Stroud, Tricia J. Vos, Gabriel S. Weatherhead, Deborah R. Wysong, Mengkun Zhang, Joseph B. Bolen, Christopher F. Claiborne
Increased Aurora A expression occurs in a variety of human cancers and induces chromosomal abnormalities during mitosis associated with tumor initiation and progression. MLN8054 is a selective small-molecule Aurora A kinase inhibitor that has entered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9605e9dd7b335154d63c66d2f6f76b7
https://europepmc.org/articles/PMC1820716/
https://europepmc.org/articles/PMC1820716/
Autor:
Cen O; Department of Medicine, Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Kannan K; Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, USA., Huck Sappal J; Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, USA., Yu J; Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, USA., Zhang M; Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, USA., Arikan M; Istanbul University, Institute of Experimental Medicine, Istanbul, Turkey., Ucur A; Istanbul University, Institute of Experimental Medicine, Istanbul, Turkey., Ustek D; Istanbul University, Institute of Experimental Medicine, Istanbul, Turkey., Cen Y; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Gordon L; Department of Medicine, Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Longnecker R; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA r-longnecker@northwestern.edu.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Publikováno v:
MSphere [mSphere] 2018 Aug 22; Vol. 3 (4). Date of Electronic Publication: 2018 Aug 22.
Autor:
Hyer ML; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Milhollen MA; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Ciavarri J; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Fleming P; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Traore T; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Sappal D; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Huck J; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Shi J; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Gavin J; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Brownell J; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Yang Y; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Stringer B; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Griffin R; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Bruzzese F; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Soucy T; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Duffy J; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Rabino C; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Riceberg J; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Hoar K; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Lublinsky A; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Menon S; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Sintchak M; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Bump N; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Pulukuri SM; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Langston S; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Tirrell S; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Kuranda M; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Veiby P; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Newcomb J; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Li P; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Wu JT; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Powe J; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Dick LR; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Greenspan P; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Galvin K; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Manfredi M; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Claiborne C; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Amidon BS; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA., Bence NF; Takeda Pharmaceuticals Inc., Cambridge, Massachusetts, USA.
Publikováno v:
Nature medicine [Nat Med] 2018 Feb; Vol. 24 (2), pp. 186-193. Date of Electronic Publication: 2018 Jan 15.
Autor:
Sells TB; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Chau R; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Ecsedy JA; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Gershman RE; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Hoar K; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Huck J; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Janowick DA; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Kadambi VJ; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., LeRoy PJ; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Stirling M; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Stroud SG; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Vos TJ; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Weatherhead GS; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Wysong DR; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Zhang M; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Balani SK; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Bolen JB; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Manfredi MG; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States., Claiborne CF; Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States.
Publikováno v:
ACS medicinal chemistry letters [ACS Med Chem Lett] 2015 Apr 22; Vol. 6 (6), pp. 630-4. Date of Electronic Publication: 2015 Apr 22 (Print Publication: 2015).