Zobrazeno 1 - 10 of 34 pro vyhledávání: '"Jessica J Gierut"'
1
Akademický článek
The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile.
Autor: Jesse Lyons, Phaedra C Ghazi, Alina Starchenko, Alessio Tovaglieri, Katherine R Baldwin, Emily J Poulin, Jessica J Gierut, Casie Genetti, Vijay Yajnik, David T Breault, Douglas A Lauffenburger, Kevin M Haigis
Publikováno v: PLoS Biology, Vol 16, Iss 3, p e2002417 (2018)
Inflammatory bowel disease (IBD) is a chronic condition driven by loss of homeostasis between the mucosal immune system, the commensal gut microbiota, and the intestinal epithelium. Our goal is to understand how these components of the intestinal eco
Externí odkaz: https://doaj.org/article/47ef114201964675b32fd68e61204548
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7
Akademický článek
Oncogenic K-Ras promotes proliferation in quiescent intestinal stem cells
Autor: Jessica J. Gierut, Jesse Lyons, Manasvi S. Shah, Casie Genetti, David T. Breault, Kevin M. Haigis
Publikováno v: Stem Cell Research, Vol 15, Iss 1, Pp 165-171 (2015)
K-Ras is a monomeric GTPase that controls cellular and tissue homeostasis. Prior studies demonstrated that mutationally activated K-Ras (K-RasG12D) signals through MEK to promote expansion and hyperproliferation of the highly mitotically active trans
Externí odkaz: https://doaj.org/article/3dee5274a11e4913bd46d24fa9fd4da2
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9
K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif
Autor: Mathew S. Lopes, Mark R. Philips, Jessica J. Gierut, James J. Fiordalisi, Kevin M. Haigis, Mo Zhou, Odis Ponce, Adrienne D. Cox, Frederick D. Tsai, Helen Court
Publikováno v: Proceedings of the National Academy of Sciences. 112:779-784
The two products of the KRAS locus, K-Ras4A and K-Ras4B, are encoded by alternative fourth exons and therefore, possess distinct membrane-targeting sequences. The common activating mutations occur in exons 1 or 2 and therefore, render both splice var
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc6938582cf494c44775fda1a2d6cfc3
https://doi.org/10.1073/pnas.1412811112
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10
Pathology and Molecular Pathology of Colorectal Cancer
Autor: Kevin M. Haigis, Jeanne Shen, Jessica J. Gierut, Emily J. Poulin
Publikováno v: Pathology and Epidemiology of Cancer ISBN: 9783319351513
Colorectal cancer (CRC) is a common disease that affects men and women of all racial and ethnic groups. This year, it is estimated that 136,830 people will be diagnosed with CRC and approximately 50,310 people will die of the disease in the United St
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::848928f7072abacc7b20a092540a5e1a
https://doi.org/10.1007/978-3-319-35153-7_22
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