Liquid biomarkers of macrophage dysregulation and circulating spike protein illustrate the biological heterogeneity in patients with post-acute sequelae of COVID-19

Autor: Christoph Schultheiß, Edith Willscher, Lisa Paschold, Cornelia Gottschick, Bianca Klee, Lidia Bosurgi, Jochen Dutzmann, Daniel Sedding, Thomas Frese, Matthias Girndt, Jessica I. Höll, Michael Gekle, Rafael Mikolajczyk, Mascha Binder

Publikováno v: Journal of medical virologyREFERENCES. 95(1)

Post-acute sequelae of COVID-19 (PASC) are long-term consequences of SARS-CoV-2 infection that can substantially impair the quality of life. Underlying mechanisms ranging from persistent viruses to innate and adaptive immune dysregulation have been d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::868a8e8e41b85b5103d0e29b8aa9b7de
https://pubmed.ncbi.nlm.nih.gov/36458566

From online data collection to identification of disease mechanisms: The IL-1ß, IL-6 and TNF-α cytokine triad is associated with post-acute sequelae of COVID-19 in a digital research cohort

Autor: Christoph Schultheiß, Edith Willscher, Lisa Paschold, Cornelia Gottschick, Bianca Klee, Svenja-Sibylla Henkes, Lidia Bosurgi, Jochen Dutzmann, Daniel Sedding, Thomas Frese, Matthias Girndt, Jessica I. Höll, Michael Gekle, Rafael Mikolajczyk, Mascha Binder

Background: The COVID-19 pandemic called for a fast conduct of studies to establish vaccines and therapies, but also to identify the natural history and drivers of post-acute sequelae of COVID-19 (PASC). Digital epidemiology may serve this aim by rap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::387e81889b101273a5ccbb156cc002d7
https://doi.org/10.1101/2021.11.16.21266391

EBV Negative Lymphoma and Autoimmune Lymphoproliferative Syndrome Like Phenotype Extend the Clinical Spectrum of Primary Immunodeficiency Caused by STK4 Deficiency

Autor: Bernhard Fleckenstein, Sebastian Ginzel, David Schlütermann, Schafiq Nabhani, Andrea Hönscheid, Polina Stepensky, Prasad T. Oommen, Cyrill Schipp, Arndt Borkhardt, Björn Stork, Ute Fischer, Jessica I. Höll

Publikováno v: Frontiers in Immunology
Front. Immunol. 9:2400
Frontiers in Immunology, Vol 9 (2018)

Serine/threonine kinase 4 (STK4) deficiency is an autosomal recessive genetic condition that leads to primary immunodeficiency (PID) typically characterized by lymphopenia, recurrent infections and Epstein Barr Virus (EBV) induced lymphoproliferation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb05e0dd3d93323c046dc053521dfe4
https://doi.org/10.3389/fimmu.2018.02400

Spezialisierte ambulante Palliativversorgung (SAPV) von Kindern mit schweren, irreversiblen, nicht progredienten Erkrankungen der TfSL (Together for Short Lives) Gruppe 4

Autor: O Dechert, Jessica I. Höll, Stefan Balzer, M Kuhlen, G Janßen, F Distelmaier, Gabriele Gagnon, Laura Trocan

Publikováno v: 67. Jahrestagung der Norddeutschen Gesellschaft für Kinder-und Jugendmedizin (NDGKJ); 20180413-20180414; Bremen; DOC18ndgkj08 /20180412/

Hintergrund: In der TfSL Gruppe 4 werden Kinder, Jugendliche und junge Erwachsenen (CAYA) mit irreversiblen, aber nicht progredienten Erkrankungen zusammengefasst. Diese stellen die anteilsmäßig größte Gruppe in der pädiatrischen SAPV dar. Aufgr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa7ad2aaae21ef224181bb0b8779bb8
https://doi.org/10.1055/s-0038-1669348

Aberrantly expressed stem cell associated protein PIWIL4 acts as a piRNA binding, epigenetically active and growth regulatory factor in human acute myeloid leukemia

Autor: Andreas Kloetgen, Naidu M. Vegi, Christoph Plass, Hartmut Döhner, Shiva Bamezai, Christian Buske, Michaela Feuring-Buske, Fengbiao Zhou, Christian Rohde, Vijay P.S. Rawat, Medhanie A. Mulaw, Konstanze Döhner, Carsten Müller-Tidow, Alexei A. Aravin, Arndt Borkhardt, Jessica I. Höll

Publikováno v: Experimental Hematology. 53:S129

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20e39c23b45c3d92ee705c8a303240c8
https://doi.org/10.1016/j.exphem.2017.06.326