Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jessica Huck Sappal"'
Autor:
Dejan Juric, Minal Barve, Ulka Vaishampayan, Desamparados Roda, Aitana Calvo, Noelia Martinez Jañez, Jose Trigo, Alastair Greystoke, R. Donald Harvey, Anthony J. Olszanski, Mateusz Opyrchal, Alexander Spira, Fiona Thistlethwaite, Begoña Jiménez, Jessica Huck Sappal, Karuppiah Kannan, Jason Riley, Cheryl Li, Cong Li, Richard C. Gregory, Harry Miao, Shining Wang
Publikováno v:
Cancer Medicine, Vol 13, Iss 5, Pp n/a-n/a (2024)
Abstract Mivavotinib (TAK‐659/CB‐659), a dual SYK/FLT3 inhibitor, reduced immunosuppressive immune cell populations and suppressed tumor growth in combination with anti‐PD‐1 therapy in cancer models. This dose‐escalation/expansion study inv
Externí odkaz:
https://doaj.org/article/543c6b5130f7472f8fd3b9ea9ea6f7e2
Autor:
Osman Cen, Karuppiah Kannan, Jessica Huck Sappal, Jie Yu, Mengkun Zhang, Muzaffer Arikan, Ali Ucur, Duran Ustek, Yeter Cen, Leo Gordon, Richard Longnecker
Publikováno v:
mSphere, Vol 3, Iss 4 (2018)
ABSTRACT Epstein-Barr virus (EBV) is associated with several B and epithelial cell cancers. EBV-encoded latent membrane protein 2A (LMP2A) contributes to cellular transformation by mimicking B cell receptor signaling. LMP2A/MYC double transgenic mice
Externí odkaz:
https://doaj.org/article/48f85aa45d2b44e28e440291bf2c7228
Autor:
Toshiyuki Takeuchi, Tadahiro Nambu, Jessica Huck Sappal, Kazumasa Miyamoto, Akifumi Kogame, Kurt Eng, Yukie Kashima, Kazuyo Kakoi, Shun-Ichiro Kageyama, Karuppiah Kannan, Hiroshi Haeno, Saomi Murai, Akihiro Ohashi, Jie Yu, Masamitsu Gotou, Osamu Kurasawa, Huifeng Niu, Kenichi Iwai
Publikováno v:
Science Advances
Potential combination partners of a CDC7 inhibitor TAK-931 were identified to guide its clinical development strategy.
Cell division cycle 7 (CDC7), a serine/threonine kinase, plays important roles in DNA replication. We developed a highly speci
Cell division cycle 7 (CDC7), a serine/threonine kinase, plays important roles in DNA replication. We developed a highly speci
Autor:
Shireen Vali, Cong Li, Shining Wang, Dean Bottino, Jessica Huck Sappal, Taher Abbasi, Yujun Wu, Kate Stumpo, Hyunjin Shin, Rick Gregory, Miguel Williams
Publikováno v:
Molecular Cancer Therapeutics. 18:A067-A067
Predicting the sensitivity of cancer cells and patient tumors to a drug remains a fundamental challenge in oncology drug development and patient care. Single-gene biomarkers of drug sensitivity ignore the crosstalk of gene aberrations seen clinically
Autor:
Mengkun Zhang, Ali Ucur, Yeter Cen, Karuppiah Kannan, Jie Yu, Duran Ustek, Leo I. Gordon, Richard Longnecker, Osman Cen, Muzaffer Arikan, Jessica Huck Sappal
Publikováno v:
mSphere, Vol 3, Iss 4 (2018)
mSphere
mSphere, Vol 3, Iss 4, p e00378-18 (2018)
mSphere
mSphere, Vol 3, Iss 4, p e00378-18 (2018)
The novel SYK and FLT3 inhibitor TAK-659 prevents the enlargement of spleen and tumor development in a mouse model of EBV-associated lymphoma by counteracting the activation of cellular kinase SYK through the viral LMP2A gene by inducing cell death i
Publikováno v:
Journal of Clinical Oncology. 36:2567-2567
2567Background: TAK-659 is a highly potent, reversible inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3) that is being tested in combination with nivolumab in patie...