Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jessica Holler"'
Autor:
Caitlin Shepard, Joella Xu, Jessica Holler, Dong-Hyun Kim, Louis M. Mansky, Raymond F. Schinazi, Baek Kim
Publikováno v:
Retrovirology, Vol 16, Iss 1, Pp 1-11 (2019)
Abstract Background Terminally differentiated/nondividing macrophages, a key target cell type of HIV-1, harbor extremely low dNTP concentrations established by a host dNTP triphosphohydrolase, SAM domain and HD domain containing protein 1 (SAMHD1). W
Externí odkaz:
https://doaj.org/article/84f81dd739a245cab04437cb7403df15
Publikováno v:
eLife, Vol 7 (2018)
The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor whose activation induces the expression of numerous genes, with many effects on cells. However, AhR activation is not known to affect the replication of viruses. We show t
Externí odkaz:
https://doaj.org/article/bf9fd6772ed746d29ab588e429e4c255
Autor:
Xijuan Liu, Adam Robinson, Alex von Kriegsheim, Ling Xie, Baek Kim, Travis S. Ptacek, Mingjie Li, Cheng Fan, Jeremy M. Simon, Xian Chen, Jörgen Bierau, Juan Liu, Charles M. Perou, Marie Zikanova, Javier Rodriguez, Jing Zhang, Jason W. Locasale, Jessica Holler, Qing Zhang, Giada Zurlo, Mamoru Takada
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications, 10:5177. Nature Publishing Group
Zurlo, G, Liu, X, Takada, M, Fan, C, Simon, J M, Ptacek, T S, Rodriguez Martinez, J, Von Kriegsheim, A, Liu, J, Locasale, J W, Robinson, A, Zhang, J, Holler, J M, Baek, K, Zikanova, M, Jorgen, B, Ling, X, Chen, X, Lie, M, Perou, C M & Zhang, Q 2019, ' Prolyl Hydroxylase Substrate Adenylosuccinate Lyase Is An Oncogenic Driver In Triple Negative Breast Cancer ', Nature Communications . https://doi.org/10.1038/s41467-019-13168-4
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications, 10:5177. Nature Publishing Group
Zurlo, G, Liu, X, Takada, M, Fan, C, Simon, J M, Ptacek, T S, Rodriguez Martinez, J, Von Kriegsheim, A, Liu, J, Locasale, J W, Robinson, A, Zhang, J, Holler, J M, Baek, K, Zikanova, M, Jorgen, B, Ling, X, Chen, X, Lie, M, Perou, C M & Zhang, Q 2019, ' Prolyl Hydroxylase Substrate Adenylosuccinate Lyase Is An Oncogenic Driver In Triple Negative Breast Cancer ', Nature Communications . https://doi.org/10.1038/s41467-019-13168-4
Protein hydroxylation affects protein stability, activity, and interactome, therefore contributing to various diseases including cancers. However, the transiency of the hydroxylation reaction hinders the identification of hydroxylase substrates. By d
Autor:
Dong-Hyun Kim, Jessica Holler, Si'Ana A. Coggins, Baek Kim, Jason T. Kimata, Raymond F. Schinazi
Publikováno v:
Virology
Unlike HIV-1, HIV-2 and some SIV strains replicate at high dNTP concentrations even in macrophages due to their accessory proteins, Vpx or Vpr, that target SAMHD1 dNTPaSe for proteasomal degradation. We previously reported that HIV-1 reverse transcri
Publikováno v:
eLife, Vol 7 (2018)
eLife
eLife
SummaryThe aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor whose activation induces the expression of numerous genes, with many effects on cells. However, AhR activation is not known to affect the replication of viruses. We
Autor:
Sarah A. Mereby, Baek Kim, Jessica Holler, Tatsuya Maehigashi, Raymond F. Schinazi, Dong-Hyun Kim
Publikováno v:
The Journal of Biological Chemistry
Lentiviruses infect both dividing CD4+ T cells and nondividing myeloid cells, and the infected myeloid cells serve as long-living viral reservoirs. Host sterile alpha motif- and histidine-aspartate domain-containing protein 1 (SAMHD1) kinetically res
Autor:
Ananda Ayyappan Jaguva Vasudevan, Baek Kim, Renate König, Karl S. Lang, Edmund Osei Kuffour, Jessica Holler, Kerstin Schott, Carsten Münk, Dieter Häussinger, Philipp A. Lang, Wolfgang A. Schulz
Publikováno v:
Journal of virology. 92(20)
The host intrinsic innate immune system drives antiviral defenses and viral restriction, which includes the production of soluble factors, such as type I and III interferon (IFN), and activation of restriction factors, including SAMHD1, a deoxynucleo
Autor:
Nina M. S. Gustafsson, Katarina Färnegårdh, Nadilly Bonagas, Anna Huguet Ninou, Petra Groth, Elisee Wiita, Mattias Jönsson, Kenth Hallberg, Jemina Lehto, Rosa Pennisi, Jessica Martinsson, Carina Norström, Jessica Hollers, Johan Schultz, Martin Andersson, Natalia Markova, Petra Marttila, Baek Kim, Martin Norin, Thomas Olin, Thomas Helleday
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Targeting the glycolytic PFKFB3 enzyme is being studied as a therapeutic strategy against cancer. Here the authors identify PFKFB3 as being involved in homologous recombination (HR) repair of DNA double strand breaks (DSBs) and present a PFKFB3 inhib
Externí odkaz:
https://doaj.org/article/a5be37faa19d4d1fbbb9c428f096c524