Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jessica Hitchcock"'
Autor:
Ian R. Henderson, David R. Withers, Saeeda Bobat, Nick D. Jones, Adam F. Cunningham, Charlotte N. Cook, Amanda E. Rossiter, Adriana Flores-Langarica, Steve P. Watson, Nonantzin Beristain-Covarrubias, Jessica L. Rooke, Ewan A. Ross, Kyoko Nakamura, Alicia Garcia-Gimenez, Ruby R Persaud, Ruth E. Coughlan, Jessica Hitchcock, Marisol Perez-Toledo, Edith Marcial-Juarez, Sian E Jossi, William M Channell
Publikováno v:
The Journal of Immunology Author Choice
Key Points T-bet−/− mice induce significant IFN-γ responses after Salmonella infection. Infection of T-bet−/− mice enhances nonprotective Th17/neutrophil responses. iNOS+ granulomas that fail to constrain Salmonella are induced in T-bet−/
Publikováno v:
Hitchcock, J, Hughes, K, Pensa, S, Lloyd-Lewis, B & Watson, C J 2022, ' The immune environment of the mammary gland fluctuates during post-lactational regression and correlates with tumour growth rate ', Development (Cambridge), vol. 149, no. 8, dev200162 . https://doi.org/10.1242/dev.200162
Post-lactational mammary gland regression encompasses extensive programmed cell death and removal of milk-producing epithelial cells, breakdown of extracellular matrix components and redifferentiation of stromal adipocytes. This highly regulated invo
Autor:
Janet Smith-Heimer, Jessica Hitchcock
Publikováno v:
Environmental Practice. 21:69-84
California is facing a severe housing shortage and needs to substantially increase housing production above current production levels to dampen soaring prices. Legislators have considered l...
Autor:
Lloyd David William King, Mark R Thomas, Adriana Flores-Langarica, William M Channell, Jessica Hitchcock, Nonantzin Beristain-Covarrubias, Adam F. Cunningham, Julie Rayes, Ian R. Henderson, Steve P. Watson, Malou Zuidscherwoude, Marisol Perez-Toledo
Publikováno v:
Blood. 133:600-604
Thrombosis is a frequent, life-threatening complication of systemic infection associated with multiple organ damage. We have previously described a novel mechanism of inflammation-driven thrombosis induced by Salmonella Typhimurium infection of mice.
Autor:
Robert A. Kingsley, Jeremy H. Lakey, Ian R. Henderson, Ewan A. Ross, Adriana Flores-Langarica, Calman A. MacLennan, Jessica Hitchcock, Kai-Michael Toellner, Laura B. Martin, Jennifer L. Marshall, Adam F. Cunningham, Constantino López-Macías, Gordon Dougan, Ian C. M. MacLennan
Publikováno v:
The Journal of Immunology. 189:5527-5532
Vaccination with purified capsular polysaccharide Vi Ag from Salmonella typhi can protect against typhoid fever, although the mechanism for its efficacy is not clearly established. In this study, we have characterized the B cell response to this vacc
Autor:
Charlotte N. Cook, Ian R. Henderson, Adam F. Cunningham, Jonathan Jobanputra, Adriana Flores-Langarica, Shizuo Akira, Saeeda Bobat, Ruth E. Coughlan, Jessica Hitchcock, Jennifer L. Marshall, Satoshi Uematsu, Ewan A. Ross
Publikováno v:
The Journal of Immunology. 189:5745-5754
Mucosal immunity is poorly activated after systemic immunization with protein Ags. Nevertheless, induction of mucosal immunity in such a manner would be an attractive and simple way to overcome the intrinsic difficulties in delivering Ag to such site
Autor:
Robin C. May, Calman A. MacLennan, John Pravin, Duncan J. Maskell, Sarah Peters, Claudia T. P. Moraes, Karina Tveen Jensen, Douglas F. Browning, Ian R. Henderson, Dhaarini Raghunathan, Adriana Flores-Langarica, Roxane M. F. Piazza, Jessica Hitchcock, Laura J. V. Piddock, Mark A. Webber, Timothy J. Wells, Faye C. Morris, Gavin K. Paterson, Denisse L. Leyton, Saeeda Bobat, Jessica M A Blair, Adam F. Cunningham, Robert K. Shaw
Publikováno v:
Infection and Immunity. 79:4342-4352
Salmonella enterica is a major cause of morbidity worldwide and mortality in children and immunocompromised individuals in sub-Saharan Africa. Outer membrane proteins of Salmonella are of significance because they are at the interface between the pat
Autor:
Nico van Rooijen, Ian C. M. MacLennan, Adam F. Cunningham, Mahmood Khan, Jessica Hitchcock, Elodie Mohr, Ian R. Henderson, Ewan A. Ross, Saeeda Bobat, Ruth E. Coughlan, Adriana Flores-Langarica, Jennifer L. Marshall
Publikováno v:
European Journal of Immunology, 41(9), 2654-2665. Wiley-VCH Verlag
Flores-Langarica, A, Marshall, J L, Bobat, S, Mohr, E, Hitchcock, J, Ross, E A, Coughlan, R E, Khan, M, van Rooijen, N, Henderson, I R, MacLennan, I C & Cunningham, A F 2011, ' T-zone localized monocyte-derived dendritic cells promote Th1 priming to Salmonella ', European Journal of Immunology, vol. 41, no. 9, pp. 2654-2665 . https://doi.org/10.1002/eji.201141440
Flores-Langarica, A, Marshall, J L, Bobat, S, Mohr, E, Hitchcock, J, Ross, E A, Coughlan, R E, Khan, M, van Rooijen, N, Henderson, I R, MacLennan, I C & Cunningham, A F 2011, ' T-zone localized monocyte-derived dendritic cells promote Th1 priming to Salmonella ', European Journal of Immunology, vol. 41, no. 9, pp. 2654-2665 . https://doi.org/10.1002/eji.201141440
Control of intracellular Salmonella infection requires Th1 priming and IFN-γ production. Here, we show that efficient Th1 priming after Salmonella infection requires CD11c(+) CD11b(hi) F4/80(+) monocyte-derived dendritic cells (moDCs). In non-infect
Autor:
Cristina Gil-Cruz, Saeeda Bobat, Denisse L. Leyton, Ian C. M. MacLennan, Rebecca Chester, Jayne L. Chamberlain, Adriana Flores-Langarica, Margaret Goodall, Ian R. Henderson, Fabrina Gaspal, Jessica Hitchcock, Shirdi E. Letran, Karine Serre, Gordon Dougan, Constantino López-Macías, Robert A. Kingsley, James Alexander, Adam F. Cunningham, Jennifer L. Marshall
Publikováno v:
European Journal of Immunology. 41:1606-1618
Clearance of disseminated Salmonella infection requires bacterial-specific Th1 cells and IFN-γ production, and Th1-promoting vaccines are likely to help control these infections. Consequently, vaccine design has focused on developing Th1-polarizing
Autor:
Sahithi J. Kuravi, Mohammed Alassiri, Francesca Barone, Saba Nayar, Joseph Robinson, Christopher D. Buckley, Parth Narendran, Helen M. McGettrick, Lucy S. K. Walker, David A. Copland, Jessica Hitchcock, Karim Raza, Bonita H. R. Apta, Arjun Odedra, Andrew Filer, Amy Kennedy, Clara M. Yates, Andrew D. Dick, Myriam Chimen, Ashley Martin, Gerard B. Nash, G. Ed Rainger, Neena Kalia, Matthew J. Harrison, Adam F. Cunningham
Publikováno v:
Nature medicine. 21(5)
During an inflammatory response, lymphocyte recruitment into tissue must be tightly controlled because dysregulated trafficking contributes to the pathogenesis of chronic disease. Here we show that during inflammation and in response to adiponectin,