Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Jessica Gasparello"'
Autor:
Alessia Finotti, Jessica Gasparello, Cristina Zuccato, Lucia Carmela Cosenza, Enrica Fabbri, Nicoletta Bianchi, Roberto Gambari
Publikováno v:
Genes, Vol 14, Iss 10, p 1927 (2023)
The anticancer drug mithramycin (MTH), has been proposed for drug repurposing after the finding that it is a potent inducer of fetal hemoglobin (HbF) production in erythroid precursor cells (ErPCs) from β-thalassemia patients. In this respect, previ
Externí odkaz:
https://doaj.org/article/523d7b40e7994f5a8875e126218fac9f
Autor:
Matteo Zurlo, Cristina Zuccato, Lucia Carmela Cosenza, Jessica Gasparello, Maria Rita Gamberini, Alice Stievano, Monica Fortini, Marco Prosdocimi, Alessia Finotti, Roberto Gambari
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 20, p 15049 (2023)
The β-thalassemias are hereditary monogenic diseases characterized by a low or absent production of adult hemoglobin and excess in the content of α-globin. This excess is cytotoxic for the erythroid cells and responsible for the β-thalassemia-asso
Externí odkaz:
https://doaj.org/article/c0382c4011cb481eba8fab3644c2458e
Autor:
Roberto Gambari, Cristina Zuccato, Lucia Carmela Cosenza, Matteo Zurlo, Jessica Gasparello, Alessia Finotti, Maria Rita Gamberini, Marco Prosdocimi
Publikováno v:
Biology, Vol 12, Iss 9, p 1202 (2023)
In this review article, we present the fascinating story of rapamycin (sirolimus), a drug able to induce γ-globin gene expression and increased production of fetal hemoglobin (HbF) in erythroid cells, including primary erythroid precursor cells (ErP
Externí odkaz:
https://doaj.org/article/9b516fe69a7b4406aa1fd7419ea2538d
Autor:
Jessica Gasparello, Chiara Papi, Matteo Zurlo, Stefano Volpi, Roberto Gambari, Roberto Corradini, Alessandro Casnati, Francesco Sansone, Alessia Finotti
Publikováno v:
Pharmaceutics, Vol 15, Iss 8, p 2121 (2023)
One of the most appealing approaches for regulating gene expression, named the “microRNA therapeutic” method, is based on the regulation of the activity of microRNAs (miRNAs), the intracellular levels of which are dysregulated in many diseases, i
Externí odkaz:
https://doaj.org/article/61237ea7126749d5877537ce7838f30a
Autor:
Lucia Carmela Cosenza, Jessica Gasparello, Nicola Romanini, Matteo Zurlo, Cristina Zuccato, Roberto Gambari, Alessia Finotti
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 507-523 (2021)
Gene editing by the CRISPR-Cas9 nuclease system technology can be considered among the most promising strategies to correct hereditary mutations in a variety of monogenic diseases. In this paper, we present for the first time the correction, by CRISP
Externí odkaz:
https://doaj.org/article/c341716d7de144c7b048cb6790ed1339
Autor:
Cristina Zuccato, Lucia Carmela Cosenza, Matteo Zurlo, Jessica Gasparello, Chiara Papi, Elisabetta D’Aversa, Giulia Breveglieri, Ilaria Lampronti, Alessia Finotti, Monica Borgatti, Chiara Scapoli, Alice Stievano, Monica Fortini, Eric Ramazzotti, Nicola Marchetti, Marco Prosdocimi, Maria Rita Gamberini, Roberto Gambari
Publikováno v:
Therapeutic Advances in Hematology, Vol 13 (2022)
Introduction: β-thalassemia is caused by autosomal mutations in the β-globin gene, which induce the absence or low-level synthesis of β-globin in erythroid cells. It is widely accepted that a high production of fetal hemoglobin (HbF) is beneficial
Externí odkaz:
https://doaj.org/article/3a428c6ac29340b587bac650085e82e1
Autor:
Chiara Tupini, Matteo Zurlo, Jessica Gasparello, Irene Lodi, Alessia Finotti, Thomas Scattolin, Fabiano Visentin, Roberto Gambari, Ilaria Lampronti
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1332 (2023)
Combined treatments employing lower concentrations of different drugs are used and studied to develop new and more effective anticancer therapeutic approaches. The combination therapy could be of great interest in the controlling of cancer. Regarding
Externí odkaz:
https://doaj.org/article/c8172d0bf8a8415a81a2c3d8e42afc6b
Autor:
Chiara Papi, Jessica Gasparello, Matteo Zurlo, Lucia Carmela Cosenza, Roberto Gambari, Alessia Finotti
Publikováno v:
Non-Coding RNA, Vol 9, Iss 2, p 29 (2023)
(1) Background: MicroRNAs are involved in the expression of the gene encoding the chloride channel CFTR (Cystic Fibrosis Transmembrane Conductance Regulator); the objective of this short report is to study the effects of the treatment of bronchial ep
Externí odkaz:
https://doaj.org/article/4b1c2c4c6c6049969c434e3cd3914a11
Autor:
Matteo Zurlo, Jessica Gasparello, Lucia Carmela Cosenza, Giulia Breveglieri, Chiara Papi, Cristina Zuccato, Roberto Gambari, Alessia Finotti
Publikováno v:
Genes, Vol 14, Iss 3, p 556 (2023)
One of the most relevant pathophysiological hallmarks of β-thalassemia is the accumulation of toxic α-globin chains inside erythroid cells, which is responsible for their premature death (hemolysis). In this context, the availability of an experime
Externí odkaz:
https://doaj.org/article/61c8a34c10744fe69cbeb1b2f416dd2c
Autor:
Jessica Gasparello, Chiara Papi, Matteo Zurlo, Lucia Carmela Cosenza, Giulia Breveglieri, Cristina Zuccato, Roberto Gambari, Alessia Finotti
Publikováno v:
PLoS ONE, Vol 17, Iss 4, p e0266419 (2022)
The pandemic caused by the SARS-CoV-2 virus (COVID-19) is still a major health issue. The COVID-19 pandemic has forced the university teaching to consider in high priority the switch from in-presence teaching to remote teaching, including laboratory
Externí odkaz:
https://doaj.org/article/31b128fba2004337b5d0ab93a8521807