Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Jessica Frankum"'
Autor:
Stephen J. Pettitt, Dragomir B. Krastev, Inger Brandsma, Amy Dréan, Feifei Song, Radoslav Aleksandrov, Maria I. Harrell, Malini Menon, Rachel Brough, James Campbell, Jessica Frankum, Michael Ranes, Helen N. Pemberton, Rumana Rafiq, Kerry Fenwick, Amanda Swain, Sebastian Guettler, Jung-Min Lee, Elizabeth M. Swisher, Stoyno Stoynov, Kosuke Yusa, Alan Ashworth, Christopher J. Lord
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The mechanisms of PARP inhibitor (PARPi) resistance are poorly understood. Here the authors employ a CRISPR mutagenesis approach to identify PARP1 mutants causing PARPi resistance and find that PARP1 mutations are tolerated in BRCA1 mutated cells, su
Externí odkaz:
https://doaj.org/article/1eb977c74fb546b0a7321e49be5d0643
Autor:
Dalia Tarantino, Callum Walker, Daniel Weekes, Helen Pemberton, Kathryn Davidson, Gonzalo Torga, Jessica Frankum, Ana M. Mendes-Pereira, Cynthia Prince, Riccardo Ferro, Rachel Brough, Stephen J. Pettitt, Christopher J. Lord, Anita Grigoriadis, Andrew NJ Tutt
Publikováno v:
Oncogene. 41:3969-3977
HORMAD1 expression is usually restricted to germline cells, but it becomes mis-expressed in epithelial cells in ~60% of triple-negative breast cancers (TNBCs), where it is associated with elevated genomic instability (1). HORMAD1 expression in TNBC i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c272a920f0ce318442b219838bdd65be
https://doi.org/10.1038/s41388-022-02369-9
https://doi.org/10.1038/s41388-022-02369-9
Autor:
Samuel Waxman, Ming-Ming Zhou, Eduardo Farias, Arthur Zelent, Christopher J. Lord, Alan Ashworth, Yordan Sbirkov, Rachel Brough, Jessica Frankum, Edgardo V. Ariztia, Rajal Sharma, Shuai Yang, Nidhi Bansal, Rossitza Christova, Veronica Gil, Louise Howell, Mihaly Mezei, Lei Zeng, Boris A. Leibovitch, Kevin Petrie, Yeon-Jin Kwon
Supplementary Table S1 and Fig S1 and S2. Supplementary Table 1: qPCR primers used in this study; Supplementary Figure S1: Structures of compounds screened in Figure 1A and 1B; Supplementary Figure S2: Proximity ligation assay (PLA) analyzing SIN3A-M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2661226bcf1adfebdb4ad0b4e75309
https://doi.org/10.1158/1535-7163.22501737.v1
https://doi.org/10.1158/1535-7163.22501737.v1
Autor:
Christopher J. Lord, Alan Ashworth, Stephen J. Pettitt, Nicholas C. Turner, Aditi Gulati, James Campbell, Nicholas Badham, Rumana Rafiq, Jessica Frankum, Helen N. Pemberton, Isaac Garcia-Murillas, Asha Konde, Malini Menon, Inger Brandsma, Rachel Brough, Chris T. Williamson, Amy Dréan
Figure S1: Characterisation of CAPAN1-B2S* Figure S2: Characterisation of SUM149-B1S* Figure S3: Sensitivity of ddPCR assay. Figure S4: Olaparib and talazoparib select for secondary mutant tumour cells. Figure S5: DLD1 tumour cells have a fitness adv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c87fbc8e38f13dde6b24d9910847b29
https://doi.org/10.1158/1535-7163.22508823.v1
https://doi.org/10.1158/1535-7163.22508823.v1
Autor:
Christopher J. Lord, Alan Ashworth, Andrew N.J. Tutt, Jos Jonkers, Patrick W.B. Derksen, Colm J. Ryan, Rachael Natrajan, Spiros Linardopoulos, Mitch Dowsett, Lesley-Ann Martin, Elinor J. Sawyer, Fredrik Wallberg, Patrycja Gazinska, Irene Chong, Marta Llorca Cardenosa, Mark D. Gurden, Stephen J. Pettitt, Rahul Kumar, Aditi Gulati, James Campbell, Malini Menon, Dragomir B. Krastev, Asha Konde, Rumana Rafiq, Feifei Song, Jessica Frankum, Helen N. Pemberton, Rachel Brough, Marieke van de Ven, Rebecca Marlow, Ilirjana Bajrami
Lagging chromosomes in E-cadherin defective cell exposed to foretinib leading to failed cytokinesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a46a503990fcd013cf24e9120ca5907e
https://doi.org/10.1158/2159-8290.22532777.v1
https://doi.org/10.1158/2159-8290.22532777.v1
Autor:
Andrew N.J. Tutt, Anita Grigoriadis, Melinda L. Telli, James M. Ford, Shaveta Vinayak, Alan Ashworth, Christopher J. Lord, Jessica Frankum, Hasan Mirza, Maggie C.U. Cheang, Anders Isaksson, Markus Mayrhofer, Maria Jasin, Fabio Vanoli, Sarah Pinder, Cheryl Gillett, Bhavna Sidhu, Shalaka Joshi, Patrycja Gazinska, Vandna Shah, Daniel Weekes, Johnathan Watkins
Supplementary Figure S1. Frequency of genomic aberrations in the KCL TNBC cohort. Supplementary Figure S2. Conceptual diagrams of Scores of Chromosomal Instability Scarring (SCINS). Supplementary Figure S3. Extent and location of SCINS in TNBC. Suppl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::094e1985f5e799065b529af5433df180
https://doi.org/10.1158/2159-8290.22531226.v1
https://doi.org/10.1158/2159-8290.22531226.v1
Autor:
Samuel Waxman, Ming-Ming Zhou, Eduardo Farias, Arthur Zelent, Christopher J. Lord, Alan Ashworth, Yordan Sbirkov, Rachel Brough, Jessica Frankum, Edgardo V. Ariztia, Rajal Sharma, Shuai Yang, Nidhi Bansal, Rossitza Christova, Veronica Gil, Louise Howell, Mihaly Mezei, Lei Zeng, Boris A. Leibovitch, Kevin Petrie, Yeon-Jin Kwon
Supplementary Table S2. List of genes with expression regulated by selamectin treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359c53a496fbbd8957c2887bf8f293a8
https://doi.org/10.1158/1535-7163.22501731.v1
https://doi.org/10.1158/1535-7163.22501731.v1
Autor:
Andrew N.J. Tutt, Anita Grigoriadis, Melinda L. Telli, James M. Ford, Shaveta Vinayak, Alan Ashworth, Christopher J. Lord, Jessica Frankum, Hasan Mirza, Maggie C.U. Cheang, Anders Isaksson, Markus Mayrhofer, Maria Jasin, Fabio Vanoli, Sarah Pinder, Cheryl Gillett, Bhavna Sidhu, Shalaka Joshi, Patrycja Gazinska, Vandna Shah, Daniel Weekes, Johnathan Watkins
Supplementary Methods, Figure Legends, Table Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f34678b3a6f52c27a52aa3119cc173
https://doi.org/10.1158/2159-8290.22531220
https://doi.org/10.1158/2159-8290.22531220
Autor:
Christopher J. Lord, Alan Ashworth, Andrew N.J. Tutt, Jos Jonkers, Patrick W.B. Derksen, Colm J. Ryan, Rachael Natrajan, Spiros Linardopoulos, Mitch Dowsett, Lesley-Ann Martin, Elinor J. Sawyer, Fredrik Wallberg, Patrycja Gazinska, Irene Chong, Marta Llorca Cardenosa, Mark D. Gurden, Stephen J. Pettitt, Rahul Kumar, Aditi Gulati, James Campbell, Malini Menon, Dragomir B. Krastev, Asha Konde, Rumana Rafiq, Feifei Song, Jessica Frankum, Helen N. Pemberton, Rachel Brough, Marieke van de Ven, Rebecca Marlow, Ilirjana Bajrami
The cell adhesion glycoprotein E-cadherin (CDH1) is commonly inactivated in breast tumors. Precision medicine approaches that exploit this characteristic are not available. Using perturbation screens in breast tumor cells with CRISPR/Cas9-engineered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a759d0659ac60046b51092f46f3457
https://doi.org/10.1158/2159-8290.c.6546827
https://doi.org/10.1158/2159-8290.c.6546827
Autor:
Samuel Waxman, Ming-Ming Zhou, Eduardo Farias, Arthur Zelent, Christopher J. Lord, Alan Ashworth, Yordan Sbirkov, Rachel Brough, Jessica Frankum, Edgardo V. Ariztia, Rajal Sharma, Shuai Yang, Nidhi Bansal, Rossitza Christova, Veronica Gil, Louise Howell, Mihaly Mezei, Lei Zeng, Boris A. Leibovitch, Kevin Petrie, Yeon-Jin Kwon
Triple-negative breast cancers (TNBC) lacking estrogen, progesterone, and HER2 receptors account for 10% to 20% of breast cancer and are indicative of poor prognosis. The development of effective treatment strategies therefore represents a pressing u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56370da14bb776869d71153456a22616
https://doi.org/10.1158/1535-7163.c.6536886.v1
https://doi.org/10.1158/1535-7163.c.6536886.v1