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pro vyhledávání: '"Jessica F. Walls"'
Autor:
Simon J. Lawless, Nidhi Kedia-Mehta, Jessica F. Walls, Ryan McGarrigle, Orla Convery, Linda V. Sinclair, Maria N. Navarro, James Murray, David K. Finlay
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Glucose is an important nutrient that feeds into glycolytic control of T cell function and differentiation. Here the authors show that T cells are superior to dendritic cells (DC) at glucose uptake, and by depriving DCs of this nutrient in their micr
Externí odkaz:
https://doaj.org/article/8b6f6381f79247dc8ef24920ae6d6002
Autor:
Jessica F Walls, Jeff J Subleski, Erika M Palmieri, Marieli Gonzalez-Cotto, Clair M Gardiner, Daniel W McVicar, David K Finlay
Publikováno v:
eLife, Vol 9 (2020)
Natural Killer (NK) cells have an important role in immune responses to viruses and tumours. Integrating changes in signal transduction pathways and cellular metabolism is essential for effective NK cells responses. The glycolytic enzyme Pyruvate Kin
Externí odkaz:
https://doaj.org/article/1481e7d755214c67a942f1f77128d836
Autor:
Daniel W. McVicar, Jessica F. Walls, Marieli Gonzalez Cotto, David K. Finlay, Clair M. Gardiner, Erika M. Palmieri, Jeff J. Subleski
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
Natural Killer (NK) cells have an important role in immune responses to viruses and tumours. Integrating changes in signal transduction pathways and cellular metabolism is essential for effective NK cells responses. The PKM2 isoform of the glycolytic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0c3196a30915ad530e6c81615e54e61
https://doi.org/10.7554/elife.59166
https://doi.org/10.7554/elife.59166
De novo polyamine synthesis supports metabolic and functional responses in activated murine NK cells
Autor:
Katie L. O’Brien, Chloe Choi, Peter J. Oefner, Eimear O'Connor, David K. Finlay, Jessica F. Walls, Clair M. Gardiner, Nadine Assmann, Cathal Keane, Katja Dettmer
Publikováno v:
European journal of immunologyReferences. 51(1)
Cellular metabolism is dynamically regulated in NK cells and strongly influences their responses. Metabolic dysfunction is linked to defective NK cell responses in diseases such as obesity and cancer. The transcription factors, sterol regulatory elem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f01dd90e437989c923fe9e4e4634314c
https://pubmed.ncbi.nlm.nih.gov/32946110
https://pubmed.ncbi.nlm.nih.gov/32946110
Publikováno v:
Seminars in immunology. 28(5)
Most cells in the body have a constant supply of nutrients, which are required to sustain cellular metabolism and functions. In contrast, cells of the immune system can encounter conditions with a limited nutrient supply during the course of an immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdacfac9c474ddc44aefbae824b7a5bc
https://pubmed.ncbi.nlm.nih.gov/27681670
https://pubmed.ncbi.nlm.nih.gov/27681670