Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jessica F. Boehler"'
Publikováno v:
Skeletal Muscle, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Background Multiple clinical trials to assess the efficacy of AAV-directed gene transfer in participants with Duchenne muscular dystrophy (DMD) are ongoing. The success of these trials currently relies on standard functional outcome measures
Externí odkaz:
https://doaj.org/article/4757d38c542643cbadde796ef0c74dc7
Autor:
James S. Novak, Marshall W. Hogarth, Jessica F. Boehler, Marie Nearing, Maria C. Vila, Raul Heredia, Alyson A. Fiorillo, Aiping Zhang, Yetrib Hathout, Eric P. Hoffman, Jyoti K. Jaiswal, Kanneboyina Nagaraju, Sebahattin Cirak, Terence A. Partridge
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Exon skipping is a strategy for the treatment of Duchenne muscular dystrophy, but has variable efficacy. Here, the authors show that dystrophin restoration occurs preferentially in areas of myofiber regeneration, where antisense oligonucleotides are
Externí odkaz:
https://doaj.org/article/2bba740be75c451786064cc88308d9ee
Autor:
James S. Novak, Marshall W. Hogarth, Jessica F. Boehler, Marie Nearing, Maria C. Vila, Raul Heredia, Alyson A. Fiorillo, Aiping Zhang, Yetrib Hathout, Eric P. Hoffman, Jyoti K. Jaiswal, Kanneboyina Nagaraju, Sebahattin Cirak, Terence A. Partridge
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
The originally published version of this Article contained an error in Figure 6. In panel b, the top graph (BrdU 21–24d) and the bottom graph (BrdU 28–31d) were inadvertently swapped. This error has now been corrected in both the PDF and HTML ver
Externí odkaz:
https://doaj.org/article/a9e3c5af6e8f42de973b74b8f858aefb
Autor:
Joanna E Parkes, Jessica F Boehler, Ning Li, Ryan M Kendra, Terrance P O’Hanlon, Eric P Hoffman, Jennifer M Peterson, Frederick W Miller, Lisa G Rider, Kanneboyina Nagaraju
Publikováno v:
Rheumatology.
Objectives The B-cell depleting biologic, rituximab, is used to treat refractory autoimmune myositis. However, the beneficial effects of rituximab appear to outweigh the known contribution of B cells in myositis. We aimed to elucidate how myositis pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e6f20e11afb4afdc8c20d2c6b26aba
https://doi.org/10.1093/rheumatology/keac687
https://doi.org/10.1093/rheumatology/keac687
Effect of endurance exercise on microRNAs in myositis skeletal muscle-A randomized controlled study.
Autor:
Jessica F Boehler, Marshall W Hogarth, Matthew D Barberio, James S Novak, Svetlana Ghimbovschi, Kristy J Brown, Li Alemo Munters, Ingela Loell, Yi-Wen Chen, Heather Gordish-Dressman, Helene Alexanderson, Ingrid E Lundberg, Kanneboyina Nagaraju
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183292 (2017)
To identify changes in skeletal muscle microRNA expression after endurance exercise and associate the identified microRNAs with mRNA and protein expression to disease-specific pathways in polymyositis (PM) and dermatomyositis (DM) patients.Following
Externí odkaz:
https://doaj.org/article/d90075eef8b740c6bdb09916a05214c1
Autor:
Jack H. Van der Meulen, Jennifer M. Peterson, Helen Johnston, Aditi Phadke, Jessica F. Boehler, Aurelia Defour, Vanessa E. Jahnke, Kanneboyina Nagaraju, Qing Yu, Jyoti K. Jaiswal, Kitipong Uaesoontrachoon
Publikováno v:
Skeletal Muscle, Vol 10, Iss 1, Pp 1-17 (2020)
Skeletal Muscle
Skeletal Muscle
BackgroundNonsense or loss-of-function mutations in the non-lysosomal cysteine protease calpain-3 result in limb-girdle muscular dystrophy type 2A (LGMD2A). While calpain-3 is implicated in muscle cell differentiation, sarcomere formation, and muscle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9690cb1760325ce68a44b35373fb3b50
https://doaj.org/article/050731eeba884453b57d2710d7a8e532
https://doaj.org/article/050731eeba884453b57d2710d7a8e532
Autor:
Cynthia J. Balog-Alvarez, Joe N. Kornegay, Sara Mata López, Kristy J. Brown, Peter P. Nghiem, Stanislav Vitha, Emily H. Canessa, Yetrib Hathout, Jessica F. Boehler, Amanda K. Bettis
Publikováno v:
Mammalian Genome. 31:95-109
The availability of an in vitro canine cell line would reduce the need for dogs for primary in vitro cell culture and reduce overall cost in pre-clinical studies. An immortalized canine muscle cell line, named Myok9, from primary myoblasts of a norma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98a3bdaa285220877fe03e8f3fd1c72e
https://doi.org/10.1007/s00335-020-09833-5
https://doi.org/10.1007/s00335-020-09833-5
Autor:
Kanneboyina Nagaraju, Qi Long Lu, Melissa Morales, Yetrib Hathout, Umar Burki, James S. Novak, Aiping Zhang, Terence A. Partridge, Katie A. Edwards, Kathleen Tatum, Eric P. Hoffman, Margaret Benny Klimek, Jack H. Van der Mulen, James L Quinn, Alyson A. Fiorillo, John van den Anker, Volker Straub, Maria Candida Vila, Jessica F. Boehler
Publikováno v:
Journal of neuromuscular diseases. 8(s2)
Background: Phosphorodiamidate morpholino oligomer (PMO)-mediated exon skipping is currently used in clinical development to treat Duchenne muscular dystrophy (DMD), with four exon-skipping drugs achieving regulatory approval. Exon skipping elicits a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6be1d995f90f46a27d768d47909c46d
https://pubmed.ncbi.nlm.nih.gov/34569970
https://pubmed.ncbi.nlm.nih.gov/34569970
Autor:
Katie A. Edwards, James S. Novak, Kanneboyina Nagaraju, Qi Long Lu, Margaret Benny Klimek, Jessica F. Boehler, Bonnie Douglas, Yi-Wen Chen, Melissa Morales, Ning Li, Maria Candida Vila, Davi A. G. Mázala, Yetrib Hathout, John van den Anker, Eric P. Hoffman, Alyson A. Fiorillo, Alexander G. Fritz, Terence A. Partridge, Marshall W. Hogarth, Travis B. Kinder, Aiping Zhang
Publikováno v:
J Pathol
Exon skipping is a promising genetic therapeutic strategy for restoring dystrophin expression in the treatment of Duchenne muscular dystrophy (DMD). The potential for newly synthesized dystrophin to trigger an immune response in DMD patients, however
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d88880d71c9fdce29503a7ff16d24c
https://doi.org/10.1002/path.5263
https://doi.org/10.1002/path.5263
Autor:
Kanneboyina Nagaraju, Jack H. Van der Meulen, Jessica F. Boehler, Marshall W. Hogarth, Apostolos Malatras, William Duddy, Sushma Medikayala, Aurelia Defour, Jyoti K. Jaiswal, Nicholas Holdreith
Publikováno v:
Human Molecular Genetics. 26:1979-1991
Repair of skeletal muscle after sarcolemmal damage involves dysferlin and dysferlin-interacting proteins such as annexins. Mice and patient lacking dysferlin exhibit chronic muscle inflammation and adipogenic replacement of the myofibers. Here, we sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07aded3af9b9ac3bd2e176a50fcd1c83
https://doi.org/10.1093/hmg/ddx065
https://doi.org/10.1093/hmg/ddx065