Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jessica Endig"'
Autor:
Bernd Geers, Julia Hagenstein, Jessica Endig, Hanna Ulrich, Laura Fleig, Paulina Sprezyna, Julita Mikulec, Lukas Heukamp, Gisa Tiegs, Linda Diehl
Publikováno v:
Cells, Vol 11, Iss 17, p 2639 (2022)
Interleukin-2 is central to the induction and maintenance of both natural (nTreg) and induced Foxp3-expressing regulatory T cells (iTreg). Thus, signals that modulate IL-2 availability may, in turn, also influence Treg homeostasis. Using global knock
Externí odkaz:
https://doaj.org/article/4c2dc861e00d45b7b722d498acbf38b2
Autor:
Ludmilla Unrau, Jessica Endig, Diane Goltz, Paulina Sprezyna, Hanna Ulrich, Julia Hagenstein, Bernd Geers, Karina Kaftan, Lukas Carl Heukamp, Gisa Tiegs, Linda Diehl
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11575 (2021)
Myeloid cells play an essential role in the maintenance of liver homeostasis, as well as the initiation and termination of innate and adaptive immune responses. In chronic hepatic inflammation, the production of transforming growth factor beta (TGF-
Externí odkaz:
https://doaj.org/article/89314a314e2c4697a1dba9997f7b133b
Autor:
Jessica Endig, Ludmilla Unrau, Paulina Sprezyna, Sebasting Rading, Meliha Karsak, Diane Goltz, Lukas C. Heukamp, Gisa Tiegs, Linda Diehl
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 22, p 5528 (2019)
Myeloid cells are essential for the initiation and termination of innate and adaptive immunity that create homeostasis in the liver. Smad7 is an inhibitor of the transforming growth factor β (TGF-β) signaling pathway, which regulates inflammatory c
Externí odkaz:
https://doaj.org/article/9f238d1f72154ede811db4339d1f0bf3
Autor:
Hanna Ulrich, Linda Diehl, Julia Hagenstein, Karina Kaftan, Lukas C. Heukamp, Bernd Geers, Paulina Sprezyna, Diane Goltz, Gisa Tiegs, Jessica Endig, Ludmilla Unrau
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 21
International Journal of Molecular Sciences, Vol 22, Iss 11575, p 11575 (2021)
Volume 22
Issue 21
International Journal of Molecular Sciences, Vol 22, Iss 11575, p 11575 (2021)
Myeloid cells play an essential role in the maintenance of liver homeostasis, as well as the initiation and termination of innate and adaptive immune responses. In chronic hepatic inflammation, the production of transforming growth factor beta (TGF-
Autor:
Alina Schreder, Dirk Haller, Florian Reisinger, Kristian Unger, Achim Weber, Thomas Longerich, Jutta Schütt, Robert Geffers, Milton J. Finegold, Ana Clara Misslitz, Alina Michael, Michael P. Manns, Laura Elisa Buitrago-Molina, Silke Marhenke, Christian Könecke, Arndt Vogel, Anna Saborowski, Thomas Clavel, Marc E. Healy, Florian P. Limbourg, Jessica Endig, Mathias Heikenwalder
Publikováno v:
Cancer Cell 30, 308-323 (2016)
Cancer Cell
Cancer Cell
Hepatocellular carcinoma (HCC) represents a classic example of inflammation-linked cancer. To characterize the role of the immune system in hepatic injury and tumor development, we comparatively studied the extent of liver disease and hepatocarcinoge
Autor:
Paulina Sprezyna, Percy A. Knolle, Lukas C. Heukamp, Linda Diehl, Felix Tolksdorf, Bernd Geers, Julita Mikulec, Waldemar Kolanus, Jessica Endig
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Scientific Reports
Scientific Reports
Interleukin-2 (IL-2) is a key regulator of adaptive immune responses but its regulation is incompletely understood. We previously found that PDL1-dependent signals were pivotal for liver sinusoidal endothelial cell-mediated priming of CD8 T cells, wh
Autor:
Sebasting Rading, Linda Diehl, Meliha Karsak, Lukas C. Heukamp, Paulina Sprezyna, Gisa Tiegs, Diane Goltz, Jessica Endig, Ludmilla Unrau
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 22
International Journal of Molecular Sciences, Vol 20, Iss 22, p 5528 (2019)
Volume 20
Issue 22
International Journal of Molecular Sciences, Vol 20, Iss 22, p 5528 (2019)
Myeloid cells are essential for the initiation and termination of innate and adaptive immunity that create homeostasis in the liver. Smad7 is an inhibitor of the transforming growth factor &beta
(TGF-&beta
) signaling pathway, which regulat
(TGF-&beta
) signaling pathway, which regulat
Autor:
Steven Dooley, Till Krech, Craig Dorrell, Stephanie Klett, Jessica Endig, Nora Schweitzer, Robert Geffers, Michael P. Manns, Aránzazu Sánchez Muñoz, Laura Elisa Buitrago-Molina, Honglei Weng, Sarah-Fee Katz, Ulrich Lehmann, Thomas Longerich, Karl Lenhard Rudolph, André Lechel, Silke Marhenke, Arndt Vogel, Johanna Orlik
Publikováno v:
Gut. 63:1501-1512
Background and aims The cyclin-dependent kinase inhibitor p21 has been implicated as a tumour suppressor. Moreover, recent genetic studies suggest that p21 might be a potential therapeutic target to improve regeneration in chronic diseases. The aim o
Autor:
Matthew H. Brush, Huihong You, Douglas N. Runckel, Joseph E. Aslan, Robert T. Youker, Laurel Thomas, Robert L. Milewski, Arndt Vogel, Jessica Endig, Hongjun Shu, Gary Thomas, Danielle M. Williamson, Haian Fu, Kam Sprott, Kenneth D. Greis, Yuhong Du, Anthony Possemato
Publikováno v:
Molecular Cell. 34:497-509
TRAIL selectively kills diseased cells in vivo, spurring interest in this death ligand as a potential therapeutic. However, many cancer cells are resistant to TRAIL, suggesting the mechanism mediating TRAIL-induced apoptosis is complex. Here we ident
Autor:
Benjamin Goeppert, Johanna Orlik, Atan Gross, S Rössler, Silke Marhenke, Jessica Endig, Arndt Vogel, Robert Geffers, Michael P. Manns, Laura Elisa Buitrago-Molina, Katharina Lobschat, Sven Schüngel
Publikováno v:
Hepatology (Baltimore, Md.). 62(3)
Apoptosis is critical for maintaining tissue homeostasis, and apoptosis evasion is considered as a hallmark of cancer. However, increasing evidence also suggests that proapoptotic molecules can contribute to the development of cancer, including liver