Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jessica E. Nesmith"'
Autor:
Timothy L. Hostelley, Jessica E. Nesmith, Emily Larkin, Amanda Jones, Daniel Boyes, Carmen C. Leitch, Magali Fontaine, Norann A. Zaghloul
Publikováno v:
Biology Open, Vol 10, Iss 6 (2021)
Pancreatic β-cells are a critical cell type in the pathology of diabetes. Models of genetic syndromes featuring diabetes can provide novel mechanistic insights into regulation of β-cells in the context of disease. We previously examined β-cell mas
Externí odkaz:
https://doaj.org/article/6bbe26babca94aefb5eec020f0f0c246
Autor:
Adebowale A. Adeyemo, Norann A. Zaghloul, Guanjie Chen, Ayo P. Doumatey, Carmen C. Leitch, Timothy L. Hostelley, Jessica E. Nesmith, Jie Zhou, Amy R. Bentley, Daniel Shriner, Olufemi Fasanmade, Godfrey Okafor, Benjamin Eghan, Kofi Agyenim-Boateng, Settara Chandrasekharappa, Jokotade Adeleye, William Balogun, Samuel Owusu, Albert Amoah, Joseph Acheampong, Thomas Johnson, Johnnie Oli, Clement Adebamowo, South Africa Zulu Type 2 Diabetes Case-Control Study, Francis Collins, Georgia Dunston, Charles N. Rotimi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Type 2 diabetes (T2D) is prevalent in populations worldwide, however, mostly studied in European and mixed-ancestry populations. Here, the authors perform a genome-wide association study for T2D in over 5,000 sub-Saharan Africans and identify a locus
Externí odkaz:
https://doaj.org/article/7757796c1cc14b99b37e09335d62edfc
Autor:
Jessica E. Nesmith, Constanza Miranda
Publikováno v:
Biomedical Engineering Education.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd59c031cbe52bddbc3b36f94876574a
https://doi.org/10.1007/s43683-022-00095-y
https://doi.org/10.1007/s43683-022-00095-y
Autor:
Daniel L. Boyes, Magali J. Fontaine, Amanda M. Jones, Norann A. Zaghloul, Emily J. Larkin, Jessica E. Nesmith, Carmen C. Leitch, Timothy L. Hostelley
Publikováno v:
Biology Open, Vol 10, Iss 6 (2021)
Biology Open
article-version (VoR) Version of Record
Biology Open
article-version (VoR) Version of Record
Pancreatic β-cells are a critical cell type in the pathology of diabetes. Models of genetic syndromes featuring diabetes can provide novel mechanistic insights into regulation of β-cells in the context of disease. We previously examined β-cell mas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::712a880d6c08e0a46174fc09c5325eb3
https://doi.org/10.1242/bio.046839
https://doi.org/10.1242/bio.046839
Autor:
Zubair M. Ahmed, Norann A. Zaghloul, Rebecca McFarland, Saumil Sethna, Carmen C. Leitch, Sukanya Lodh, Christopher J. Westlake, Maggie S. Matern, Timothy L. Hostelley, Ronna Hertzano, Jessica E. Nesmith
Publikováno v:
Hum Mol Genet
Alström syndrome (OMIM #203800) is an autosomal recessive obesity ciliopathy caused by loss-of-function mutations in the ALMS1 gene. In addition to multi-organ dysfunction, such as cardiomyopathy, retinal degeneration and renal dysfunction, the diso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a4edb4a27b9bc9a1735eb6354a184dc
https://doi.org/10.1093/hmg/ddz053
https://doi.org/10.1093/hmg/ddz053
Autor:
Kofi Agyenim-Boateng, Ayo P. Doumatey, Adebowale Adeyemo, Charles N. Rotimi, Settara C. Chandrasekharappa, Albert G.B. Amoah, Norann A. Zaghloul, Thomas Johnson, William Balogun, Daniel Shriner, Joseph Acheampong, Guanjie Chen, Jie Zhou, Olufemi Fasanmade, Clement Adebamowo, Benjamin A. Eghan, South Africa Zulu Type Diabetes Case-Control Study, Jokotade Adeleye, Jessica E. Nesmith, Francis S. Collins, Samuel Owusu, Timothy L. Hostelley, Carmen C. Leitch, Johnnie Oli, Godfrey Okafor, Georgia M. Dunston, Amy R. Bentley
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Genome analysis of diverse human populations has contributed to the identification of novel genomic loci for diseases of major clinical and public health impact. Here, we report a genome-wide analysis of type 2 diabetes (T2D) in sub-Saharan Africans,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a6cbf062e794e3bf54c14c4f9cbb616
https://pubmed.ncbi.nlm.nih.gov/31324766
https://pubmed.ncbi.nlm.nih.gov/31324766
Publikováno v:
Journal of Visualized Experiments.
The analysis of global gene expression changes is a valuable tool for identifying novel pathways underlying observed phenotypes. The zebrafish is an excellent model for rapid assessment of whole transcriptome from whole animal or individual cell popu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19bd7364b109be3d8fcba49e7ed33a54
https://doi.org/10.3791/56187-v
https://doi.org/10.3791/56187-v
Blood vessel formation is essential for vertebrate development and is primarily achieved by angiogenesis – endothelial cell sprouting from pre-existing vessels. Vessel networks expand when sprouts form new connections, a process whose regulation is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5cde8f301d3778a5b4094d1a5f6fde9
https://europepmc.org/articles/PMC5374355/
https://europepmc.org/articles/PMC5374355/
Publikováno v:
Genetics. 186:1285-1293
The anaphase promoting complex/cyclosome (APC/C) mediates the metaphase-to-anaphase transition by instructing the ubiquitination and turnover of key proteins at this stage of the cell cycle. We have recovered a gain-of-function allele in an APC5 subu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83b1b1e16aba2e1300914f288e6cde00
https://doi.org/10.1534/genetics.110.123463
https://doi.org/10.1534/genetics.110.123463
Autor:
Joseph Walpole, Feilim Mac Gabhann, John C. Chappell, Kevin P. Mouillesseaux, Jessica E. Nesmith, Shayn M. Peirce, Caitlin M. Hartland, Victoria L. Bautch, Yasmin L. Hashambhoy-Ramsay, Julia Cluceru, Vanessa B. Bradley
Publikováno v:
Cardiovascular research. 111(1)
Aims In developing blood vessel networks, the overall level of vessel branching often correlates with angiogenic sprout initiations, but in some pathological situations, increased sprout initiations paradoxically lead to reduced vessel branching and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80a37a516870626189a405a953ad9056
https://pubmed.ncbi.nlm.nih.gov/27142980
https://pubmed.ncbi.nlm.nih.gov/27142980